Cardiomyopathy — An approach to the autoimmune background

Becker, Niels-Peter; Müller, Johannes; Göttel, Peter; Wallukat, Gerd; Schimke, Ingolf

doi:10.1016/j.autrev.2017.01.012

Cited by 41 publications

(38 citation statements)

References 201 publications

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“…(46). Today, it is increasingly accepted that autoimmunity is as an important pathogenic driver of human DCM (47) and functional autoantibodies such as β1-AAB and M2-AAB diseases came to the fore (6–9). Finding a comparable autoimmunity in DoCM, additionally to all the other similarities of DoCM with human DCM summarized (21–25), would Doberman pinchers predestinate as model to investigate the autoimmune background of human DCM in general and specifically treatment strategies directed to the functional autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

“…With the finding of GPCR-AAB such as directed against the β1-adrenergic receptor (β1-AAB) and muscarinic receptor 2 (M2-AAB) (10,11) in patients with DCM of non-ischemic reasons, an autoimmune background of specifically associated with GPCR-AAB emerged. In contrast, patients with ischemic cardiomyopathy and healthy individuals carry GPCR-AAB only in very small amounts or these are completely absent (9).…”

Section: Introductionmentioning

confidence: 99%

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Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

Schimke

Wess

Wallukat

et al. 2019

Preprint

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

Schimke

Wess

Wallukat

et al. 2019

Preprint

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“…All previous autoimmune disease fulfill these criteria, but in other conditions the pathogenetic mechanism explains some clinical features, as in the case of systemic sclerosis (autoantibodies against the receptor of platelet-derived growth factor of the fibroblasts, for skin thickening and stiffness, against muscarinic AChR of the visceral smooth muscle, for gastro-intestinal dysmotility, against the type 1 angiotensin II receptor and endothelintype 1 receptor of endothelial cells, for vasoconstriction) [59], or in the case of dilated cardiomyopathy (autoantibodies against the β 1 -adrenergic receptor of the cardiomyocytes for ventricular dilatation and dysfunction) [60,61].…”

Section: Other Functionally Cell Surface Receptor Autoantibodies In Amentioning

confidence: 99%

Receptor autoimmunity: diagnostic and therapeutic implications

Tozzoli¹

2020

Autoimmun Highlights

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Receptor autoimmunity is one of the ways in which autoimmune diseases appear in humans. Graves' disease, myasthenia gravis, idiopathic membranous nephropathy, and autoimmune acute encephalitis are the major autoimmune diseases belonging to this particular group. Receptor autoimmune disease are dependent on the presence of autoantibodies directed against cell-surface antigens, namely TSH receptor in thyrocytes, acetylcholine receptor in neuromuscular junction, phospholipase 2 receptor in podocytes, and NMDA receptor in cortical neurons. In this article we outline the distinctive features of receptor autoimmunity and the specific relationship between the autoimmunology laboratory and the presence/concentration of autoantibodies. Some immunological features distinguish receptor autoimmunity. Anti-receptor autoantibody pathologies are considered T cell-dependent, B-cell-mediated autoimmune disorders: the knowledge about the presence of circulating and/or localized autoantibodies to target organs and identification of autoantigens involved in the autoimmune reaction is of paramount importance. Due to the close correlation between the concentration of anti-receptor autoantibodies, the autoimmune target of some cell-surface receptors and the intensity of symptoms, the measurement of these immunoglobulins has become central to diagnose autoimmune diseases in all affected patients, not just in clinically dubious cases. The measurement of autoantibodies is also relevant for differential diagnosis of autoimmune and non-autoimmune forms with similar symptoms. From the methodological point of view, quantitative immunoassay methods of measurement should be preferred over semi-quantitative ones, for the capacity of the first class of methods to define precisely the reference ranges and decision levels overcoming the measurement uncertainty of semi-quantitative methods.

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“…Thyroidectomy in Graves' disease has been reported to abolish the AF load [77]. It is worthwhile to note that the occurrence of AF in this condition is associated with concomitant autoantibodies toward the β1-adrenergic and the M2 muscarinic receptors [79][80][81][82][83]. These autoantibodies and T 4 facilitated the induction of AF in animal models as well [82].…”

Section: Thyroid Status Imbalance Promoting Afmentioning

confidence: 98%

Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism

Tribulová

Kurahara

Hlivák

et al. 2020

IJMS

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A perennial task is to prevent the occurrence and/or recurrence of most frequent or life-threatening cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF). VF may be lethal in cases without an implantable cardioverter defibrillator or with failure of this device. Incidences of AF, even the asymptomatic ones, jeopardize the patient’s life due to its complication, notably the high risk of embolic stroke. Therefore, there has been a growing interest in subclinical AF screening and searching for novel electrophysiological and molecular markers. Considering the worldwide increase in cases of thyroid dysfunction and diseases, including thyroid carcinoma, we aimed to explore the implication of thyroid hormones in pro-arrhythmic signaling in the pathophysiological setting. The present review provides updated information about the impact of altered thyroid status on both the occurrence and recurrence of cardiac arrhythmias, predominantly AF. Moreover, it emphasizes the importance of both thyroid status monitoring and AF screening in the general population, as well as in patients with thyroid dysfunction and malignancies. Real-world data on early AF identification in relation to thyroid function are scarce. Even though symptomatic AF is rare in patients with thyroid malignancies, who are under thyroid suppressive therapy, clinicians should be aware of potential interaction with asymptomatic AF. It may prevent adverse consequences and improve the quality of life. This issue may be challenging for an updated registry of AF in clinical practice. Thyroid hormones should be considered a biomarker for cardiac arrhythmias screening and their tailored management because of their multifaceted cellular actions.

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Cardiomyopathy — An approach to the autoimmune background

Cited by 41 publications

References 201 publications

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy

Receptor autoimmunity: diagnostic and therapeutic implications

Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism

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