Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles

Swedlund, Benjamin; Lescroart, Fabienne

doi:10.1101/cshperspect.a036731

Cited by 22 publications

(25 citation statements)

References 187 publications

(215 reference statements)

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“…As a fundamental building block of all vertebrate hearts, the interplay of FHF and SHF influences cardiac conductivity and facilitates sequential contraction (Mosimann et al, 2015); however, why two progenitor pools are required for heart formation remains uncertain. SHF descendants contribute to the increasingly complex compartmentalization in the heart of terrestrial vertebrates, culminating in a right ventricle that is dedicated to pulmonary circulation (Kelly, 2012;Koshiba-Takeuchi et al, 2009;Swedlund and Lescroart, 2019;Vincent and Buckingham, 2010).…”

Section: Heartmentioning

confidence: 99%

The lateral plate mesoderm

2020

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The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.

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Section: Heartmentioning

confidence: 99%

The lateral plate mesoderm

2020

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“…In this direction, Yuan et al [50] engineered a green fluorescent protein (GFP) reporter line of zebrafish which is driven by murine Smarcd3 enhancer (Smarcd3-F6), because its activity is detected in early gastrulating mouse mesoderm [56][57][58]. Smarcd3 is also known as Baf60c in humans, a component of the Notch signaling pathway, which regulates cardiac looping morphology or left-right asymmetry [59], remodels chromatin to regulate gene expression for heart development and function [60,61], and determines the fate of cardiomyocyte cells [62].…”

Section: Epigenomic Mapping Of Zebrafish Reveals New Insights Into Cardiac Developmentmentioning

confidence: 99%

Advances in Cardiac Development and Regeneration Using Zebrafish as a Model System for High-Throughput Research

Francoeur

Sen

2021

JDB

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Heart disease is the leading cause of death in the United States and worldwide. Understanding the molecular mechanisms of cardiac development and regeneration will improve diagnostic and therapeutic interventions against heart disease. In this direction, zebrafish is an excellent model because several processes of zebrafish heart development are largely conserved in humans, and zebrafish has several advantages as a model organism. Zebrafish transcriptomic profiles undergo alterations during different stages of cardiac development and regeneration which are revealed by RNA-sequencing. ChIP-sequencing has detected genome-wide occupancy of histone post-translational modifications that epigenetically regulate gene expression and identified a locus with enhancer-like characteristics. ATAC-sequencing has identified active enhancers in cardiac progenitor cells during early developmental stages which overlap with occupancy of histone modifications of active transcription as determined by ChIP-sequencing. CRISPR-mediated editing of the zebrafish genome shows how chromatin modifiers and DNA-binding proteins regulate heart development, in association with crucial signaling pathways. Hence, more studies in this direction are essential to improve human health because they answer fundamental questions on cardiac development and regeneration, their differences, and why zebrafish hearts regenerate upon injury, unlike humans. This review focuses on some of the latest studies using state-of-the-art technology enabled by the elegant yet simple zebrafish.

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“…The heart underwent various specializations and adaptions supporting the wide variety of vertebrate body plans. Studies on cardiac development, physiology, and regeneration across model organisms have nonetheless revealed genetic and developmental features that are common to all vertebrate hearts [ 1 , 2 , 3 ]. Driving systemic blood circulation, the zebrafish heart’s ventricle is devoid of any larger, physical compartmentalization.…”

Section: Introductionmentioning

confidence: 99%

Persistent Ventricle Partitioning in the Adult Zebrafish Heart

Pfefferli

Moran

Felker

et al. 2021

JCDD

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The vertebrate heart integrates cells from the early-differentiating first heart field (FHF) and the later-differentiating second heart field (SHF), both emerging from the lateral plate mesoderm. In mammals, this process forms the basis for the development of the left and right ventricle chambers and subsequent chamber septation. The single ventricle-forming zebrafish heart also integrates FHF and SHF lineages during embryogenesis, yet the contributions of these two myocardial lineages to the adult zebrafish heart remain incompletely understood. Here, we characterize the myocardial labeling of FHF descendants in both the developing and adult zebrafish ventricle. Expanding previous findings, late gastrulation-stage labeling using drl-driven CreERT2 recombinase with a myocardium-specific, myl7-controlled, loxP reporter results in the predominant labeling of FHF-derived outer curvature and the right side of the embryonic ventricle. Raised to adulthood, such lineage-labeled hearts retain broad areas of FHF cardiomyocytes in a region of the ventricle that is positioned at the opposite side to the atrium and encompasses the apex. Our data add to the increasing evidence for a persisting cell-based compartmentalization of the adult zebrafish ventricle even in the absence of any physical boundary.

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Cardiopharyngeal Progenitor Specification: Multiple Roads to the Heart and Head Muscles

Cited by 22 publications

References 187 publications

The lateral plate mesoderm

The lateral plate mesoderm

Advances in Cardiac Development and Regeneration Using Zebrafish as a Model System for High-Throughput Research

Persistent Ventricle Partitioning in the Adult Zebrafish Heart

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