Cardioprotection and Signaling Pathways

Marı́n-Garcı́a, José

doi:10.1007/978-1-4419-9461-5_20

Cited by 1 publication

(1 citation statement)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS plays a significant role in the pathogenesis of myocardial infarction (MI) and post-MI remodeling in mice [ 32 ]. The ROS-mediated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation can trigger inflammation and damage through upregulating tumor necrosis factor-α (TNF-α), Bcl-2-associated X protein (Bax) and transforming growth factor β1 (TGF-β1) [ 33 ]. NOX2 protein levels as well as NF-κB activity were elevated in cardiac myocytes after acute MI in the infracted area [ 33 , 34 ], supporting that NF-κB is involved in the downstream pathway of ROS.…”

Section: Oxidative Stress and Endogenous Antioxidants In Cardiac Musclementioning

confidence: 99%

Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants

et al. 2021

View full text Add to dashboard Cite

Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling, dysfunction, and failure. Cardiac myocytes possess several ROS-producing pathways, such as mitochondrial electron transport chain, NADPH oxidases, and nitric oxide synthases, and have endogenous antioxidation mechanisms. Cardiac Ca2+-signaling toolkit proteins, as well as mitochondrial functions, are largely modulated by ROS under physiological and pathological conditions, thereby producing alterations in contraction, membrane conductivity, cell metabolism and cell growth and death. Mechanical stresses under hypertension, post-myocardial infarction, heart failure, and valve diseases are the main causes for stress-induced cardiac remodeling and functional failure, which are associated with ROS-induced pathogenesis. Experimental evidence demonstrates that many cardioprotective natural antioxidants, enriched in foods or herbs, exert beneficial effects on cardiac functions (Ca2+ signal, contractility and rhythm), myocytes remodeling, inflammation and death in pathological hearts. The review may provide knowledge and insight into the modulation of cardiac pathogenesis by ROS and natural antioxidants.

show abstract