Cardioprotection by Curcumin Post-Treatment in Rats with Established Chronic Kidney Disease

Hernández‐Reséndiz, Sauri; Correa, Francisco; García-Niño, Wylly Ramsés; Buelna‐Chontal, Mabel; Roldán, Francisco Javier; Ramírez-Camacho, Ixchel; Delgado-Toral, Carolina; Carbó, Roxana; Pedraza‐Chaverrí, José; Tapia, Edilia; Zazueta, Cecilia

doi:10.1007/s10557-015-6581-x

Cited by 36 publications

(34 citation statements)

References 46 publications

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“…Apart from potential therapeutic applications, thanks to its multifaceted actions curcumin could also be important in terms of prevention of renal function decline. As already reported for CKD animal model and human studies [95,96], curcumin exhibits antioxidant properties, potentially useful in a prevention setting. In this regard, in a very recent animal study curcumin has been shown to be able to prevent early damage induced by 5/6 nephrectomy, not only ameliorating total antioxidant capacity, but also improving renal blood flow and acting in terms of mitochondrial function and bioenergetics [100].…”

Section: Curcuminsupporting

confidence: 52%

“…In a recent in vivo study, oral administration of curcumin in mice models of CKD induced several beneficial effects: amelioration of cardiac function, decrease of BP and ROS production, improvement of mitochondrial integrity and functionality. While renal function seemed to be unaffected by curcumin administration, a reduction of the expression of MMP-2, a molecule involved in cardiac remodeling, was observed [95]. Collectively, curcumin appeared to reduce cardiac remodeling, mitochondrial dysfunction and cell death mediated by oxidative stress.…”

Section: Curcuminmentioning

confidence: 93%

“…Over the last years, different scientific studies have highlighted the nutraceutical properties of this molecule, at a systemic and also renal level. In the field of renal diseases, some in vivo and human studies suggest new therapeutic perspectives for curcumin use in CKD [95,96], acute kidney injury (AKI) [97], transplantation [98,99] and renal cell carcinoma [94 The results of these research efforts need of course to be extensively validated by randomized clinical trials (RCTs). In a recent in vivo study, oral administration of curcumin in mice models of CKD induced several beneficial effects: amelioration of cardiac function, decrease of BP and ROS production, improvement of mitochondrial integrity and functionality.…”

Section: Curcuminmentioning

confidence: 99%

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Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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Section: Curcuminsupporting

confidence: 52%

Section: Curcuminmentioning

confidence: 93%

Section: Curcuminmentioning

confidence: 99%

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Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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“…In this regard, studies have documented oxidative stress and inflammation in the cardiac tissue of animals with experimental CKD. [17][18][19] CKD also results in mitochondrial depletion and dysfunction in the myocardium and skeletal muscle. 20,21 In fact, mitochondria from cardiac tissue of CKD animals were unable to retain calcium, had diminished cytochrome C levels and decreased respiratory function.…”

Section: Discussionmentioning

confidence: 99%

LCZ696 (Sacubitril/Valsartan), an Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease

Suematsu

Jing

Nunes

et al. 2018

Journal of Cardiac Failure

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Highlights The effect of LCZ696 (Sacubitril/valsartan) against cardiorenal syndrome is proposed. LCZ696 more improved CKD related heart failure than valsartan therapy alone. LCZ696 attenuated CKD related cardiac hypertrophy and fibrosis and aortic fibrosis. Effects of LCZ696 for heart are mediated by anti-inflammation and oxidative stress. LCZ696 also improved indicators of mitochondrial mass/function. AbstractBackground: Chronic kidney disease (CKD) is associated with cardiac hypertrophy, fibrosis and

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“…Alterations in the kidneys and heart occur in CKD (Hernández-Reséndiz et al, 2015;Thaung et al, 2015). Studies on these structures in this disease have so far not been addressed.…”

Section: Introductionmentioning

confidence: 99%

Impact of liraglutide versus atorvastatin on cardiovascular changes in rat model of adenine induced chronic renal failure

Shata¹,

Elmorsy²,

Elesawy³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The prevalence of cardiovascular changes markedly increases with deterioration of patient's renal function and can stack up 65 to 70% in end-stage renal disease. A rapid fall in renal function is often associated with uncontrolled congestive heart failure. Beyond their lipid-lowering effect, statins have been shown to protect the heart in different diseases. Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue, used to control diabetes. It improves cardiac dysfunction in non-diabetics, but underlying mechanisms remain to some extent, unclear. Fifty two male Sprague-Dawley rats weighing 200 to 250 g were grouped into negative control, positive control, liraglutide treated group (0.3 mg/kg), atorvastatin treated group (10 mg/kg), liraglutide and atorvastatin treated group (0.3 and 10 mg/kg, respectively), liraglutide and atorvastatin treated group (0.15 and 5 mg/kg, respectively). Combination of both drugs significantly reduce creatine phosphokinase isoenzyme (CK-MB) in both doses (p<0.008, p <0.002) and lactate dehydrognase (LDH) (p<0.04, p<0.01). Liraglutide alone or in combination with atorvastatin in both doses (p<0.02, p<0.01 and p<0.01) significantly increased superoxide dismutase (SOD). Atorvastatin alone (p<0.02) or in combination with liraglutide in both doses (p<0.001, p<0.001) induced a significant decrease of malondialdehyde (MDA). Atorvastatin alone (p<0.01) or in combination with liraglutide in both doses induced a significant amelioration of nitric oxide (NO) and cholesterol (p<0.01 and p<0.02). Significant improvements in blood urea nitrogen (BUN) and glucose profile were seen with all tested drugs either single or in combination. Combined implementation of both drugs improves histopathological changes of cardiac muscle fibres. Liraglutide has promising effects on cardiovascular changes in adenine induced chronic nephropathy through modulation of LDH, CK-MB and improvement of NO and SOD. Also, it can mitigate fibrosis and cardiac tissue changes. Its effects markedly increase in conjunction with atorvastatin. Combined administration of liraglutide and atorvastatin in a high dose has a reliable effect on improving outcome in biochemical and histopthological cardiac muscle fibers changes.

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Cardioprotection by Curcumin Post-Treatment in Rats with Established Chronic Kidney Disease

Abstract: Our findings suggest that curcumin might have therapeutic potential in treatment of heart disease in patients with established CKD by attenuating oxidative stress-related events as cardiac remodeling, mitochondrial dysfunction and cell death.

Cited by 36 publications

References 46 publications

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

LCZ696 (Sacubitril/Valsartan), an Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease

Impact of liraglutide versus atorvastatin on cardiovascular changes in rat model of adenine induced chronic renal failure

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