Cardioprotective activity of fruits of <i>Sechium edule</i>

Abstract

The present work deals with the study of the ethanolic extract of fruits of Sechium edule for cardioprotective activity. Cardioprotective activity of the ethanolic extract of fruits of S. edule was determined by the administration of isoproterenol (60 mg/kg, s.c) for two days. Pretreatment with S. edule (200 mg/kg, p.o and 100 mg/kg, p.o) for 28 days in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have shown infiltration of inflammatory cells and continuity in muscle fiber was lacking suggesting an irreversible cell injury. Animals treated with ethanolic extract of S. edule showed less degenerative changes compared to isoproterenoltreated animals. Article Info

The Effects of Ethanol Extract, Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on the High-density Lipoprotein Level in Male White Mice

“…Chayote extract using ethanol solvent contains alkaloids, flavonoids, glycosides, sapaonins, tannins and triperten (Siahaan, 2020). This study is in line with Neeraja et al (2015), that the ethanol extract 200 mg/KgBW can significantly increase HDL.…”

Chayote (Sechium edule): A review of nutritional composition, bioactivities and potential applications

“…The cardioprotective activity of the ethanolic extract of fruit was also determined in animal models. Results showed that Wistar rats treated with chayote fruit extract for 28 days significantly (p <0.01) reduced the serum levels of several enzymes (SGOT, SGPT, ALP, LDH, CK), total cholesterol, triglycerides, LDLcholesterol, VLDL-cholesterol, and increased the levels of HDL-cholesterol(Neeraja, Debnath, & Firdous, 2015). The angiotensin-converting enzyme (ACE) inhibitor nicotianamine was purified from chayote, however, its absorption and efficacy on reninangiotensin-aldosterone system was not highlighted(Hayashi, Nakayama, Aoyagi, 6.3.…”

Hydroalcoholic Extract of Sechium edule Fruits Attenuates QT Prolongation in High Fat Diet-Induced Hyperlipidemic Mice

“…The product hence obtained was reduced to a dark-colored mass by keeping in a boiling water bath for further solvent elimination. The obtained hydroalcoholic extract was preserved in a refrigerator (4°C) until further use [ 16 , 19 ].…”

“…extract was found to reduce the level of malondialdehyde [ 17 ]. A literature survey also revealed the cardioprotective property [ 19 ] of this fruit. Additionally, it has been demonstrated that the polyphenolic extract of S.E.…”