Cardioprotective and nephroprotective activities of methanolic extracts from Pulicaria somalensis herbs against carbon tetrachloride induced toxicity in rats

Yusufoglu, HS; Foudah, AI; Alam, Anwar; Soliman, GA

doi:10.1055/s-0036-1596879

Cited by 3 publications

(4 citation statements)

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“…Total protein content [ 19 ] Malondialdehyde (MDA) [ 20 ] and nonprotein sulfhydryls (NP-SH) [ 21 ] were estimated in tissue homogenates by the previously described methods. The estimation of malondialdehyde (MDA) and nonprotein sulfhydryls (NP-SH) were used for oxidative stress.…”

Section: Methodsmentioning

confidence: 99%

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Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

Shahat

Hassanein

Ullah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The goal of the current study was to assess the nephroprotective and cardioprotective potential of Moricandia sinaica methanol extract (MOR-1), as well as its butanol (MOR-2) and aqueous (MOR-3) fractions against carbon tetrachloride (CCl4)-induced nephro and cardio-toxicity. Cardiac function was assessed using the biochemical parameters lactate dehydrogenase (LDH) and creatinine kinase (CK). Renal function was examined using the biochemical parameters creatinine and uric acid. The levels of nonprotein sulfhydryls (NPSH) and malondialdehyde (MDA) were used as markers of oxidative strain. A dose of 100 and 200 mg/kg of butanol fraction given prior to CCl4 treatment significantly ( p < 0.05 − 0.001 ) protected against elevated LDH and CK levels. Similarly, treatment with silymarin (10 mg/kg) and butanol fraction (100 and 200 mg/kg) significantly ( p < 0.05 − 0.001 ) boosted total protein levels compared to CCl4 treatment alone. The silymarin (10 mg/kg) and butanol fraction (100 and 200 mg/kg) also provided a significant ( p < 0.05 − 0.001 ) protective effect for MDA levels. Methanol extract (MOR-1) and butanol (MOR-2) showed significant results and were recommended for further pharmacological and screening for active constituents.

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Section: Methodsmentioning

confidence: 99%

“…Kidney Homogenate. Total protein content [19] Malondialdehyde (MDA) [20] and nonprotein sulfhydryls (NP-SH) [21] were estimated in tissue homogenates by the previously described methods.…”

Section: Estimation Of Biochemical Markers In Heart Andmentioning

confidence: 99%

Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

Shahat

Hassanein

Ullah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Preventative treatment with beta-blockers, calcium antagonists, angiotensin-converting enzymes, and antioxidants shows promise but often comes with side effects or high dosages. This highlights the need for alternative therapies that offer better efficacy without compromising safety through further research [ 6 , 12 ]. Researchers globally are increasingly studying novel cardioprotective drugs in response to the growing incidence of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model

et al. 2023

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Myocardial infarction (MI) continues to be an important issue in healthcare systems worldwide, leading to high rates of morbidity and mortality. Despite ongoing efforts towards the development of preventive measures and treatments, addressing the challenges posed by MI remains difficult both in developed and developing countries. However, researchers recently investigated the potential cardioprotective effects of taraxerol utilizing an isoproterenol (ISO)-induced cardiotoxicity model among Sprague Dawley rats. Specifically, subcutaneous tissue injections consisting of 5.25 mg/kg or 8.5 mg/kg ISO were administered over two consecutive days as stimuli to induce cardiac injury. To investigate the possibility of preventing damage caused by ISO-induced cardiotoxicity by taraxerol treatment, five groups were formed: a normal control group (1% Tween 80), an ISO control group, an amlodipine group administered 5 mg/kg/day, and various doses of taraxerol. The study results showed that treatment significantly reduced cardiac marker enzymes. Additionally, pretreatment with taraxerol increased myocardial activity in SOD and GPx, leading to significant reductions in serum CK-MB levels along with MDA, TNF-α, and IL-6. Further histopathological analysis supported these observations, as treated animals had less cellular infiltration compared to untreated ones. These multifaceted findings suggest that oral administration of taraxerol could potentially protect hearts from ISO-caused damage by increasing endogenous antioxidant concentrations while decreasing pro-inflammatory cytokines.

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“…The plants of this genus have been used in traditional medicines for treating various ailments, such as back-pain, inflammation, menstrual cramps, intestinal disorders, dysentery and diarrhea [8,9]. They possess different bioactivities: cytotoxic, antipyretic, antioxidant, antispasmodic, antimicrobial, antihistaminic, analgesic, hepatoprotective, antiinflammatory, cardioprotective and nephroprotective [9][10][11]. This genus is known to be rich in terpenoids, phenolics, caryophyllene sterols, caryophyllenes and xanthines [9,12].…”

Section: Introductionmentioning

confidence: 99%

Pulicaria petiolaris effectively attenuates lipopolysaccharide (LPS)-induced acute lung injury in mice

Ahmed

Aljuhani

Salamah

et al. 2018

ARCH BIOL SCI BELGRA

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Members of the genus Pulicaria have been used in traditional medicine for alleviating several complaints as they have a rich pool of biometabolites. Acute lung injury (ALI) is a serious disease with an elevated mortality rate. The present investigation aimed to evaluate the total phenolic and flavonoid contents and antioxidant capacity of the methanolic extract of P. petiolaris Jaub. and Spach. (PP) (Asteraceae). Moreover, the potential protective potential of PP against lipopolysaccharide-(LPS)-induced ALI was assessed. PP is a rich source of phenolics and flavonoids. The total phenolic content (TPC) was 68.05 mg gallic acid equivalent (GAE)/g dried extract, and the total flavonoid content (TFC) was 45.86 mg quercetin equivalent (QE)/g dried extract. Additionally, PP possessed a promising DPPH-scavenging activity, with an IC 50 =27 μg/mL. Our results showed that PP lessened LPS-induced lung injury. PP effectively reduced pulmonary edema as it lowered total protein and the lung wet/dry weight (W/D) ratio in the bronchoalveolar lavage fluid (BALF). It also significantly ameliorated the level of lactate dehydrogenase (LDH) in the BALF and improved the histopathological lesions in the lung tissue. LPS-induced inflammatory cell infiltration was greatly depressed in PP-treated animals. PP showed antioxidant capacity as it reduced the LPS-induced increase in the lipid peroxidation marker, malondialdehyde (MDA). It also increased the activity of superoxide dismutase (SOD) and the content of reduced glutathione (GSH). This study indicates that PP significantly decreased LPS-induced inflammation in the LPS-mediated ALI murine model, suggesting that it may become a significant preventive strategy for treating nonspecific inflammation of the lungs.

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Cardioprotective and nephroprotective activities of methanolic extracts from Pulicaria somalensis herbs against carbon tetrachloride induced toxicity in rats

Cited by 3 publications

References 0 publications

Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model

Pulicaria petiolaris effectively attenuates lipopolysaccharide (LPS)-induced acute lung injury in mice

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