Cardioprotective Effect of Ficus hispida Linn. on Cyclophosphamide Provoked Oxidative Myocardial Injury in a Rat Model

Shanmugarajan, T. S.; Arunsundar, M.; Somasundaram, I.; Krishnakumar, E.; Sivaraman, D.; Ravichandiran, V.

doi:10.3923/ijp.2008.78.87

Cited by 37 publications

(24 citation statements)

References 49 publications

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“…These findings are in good agreement with the observations of Shanmugarajan et al (2008) regarding Ficus hispida; another very important plant of genus Ficus exhibited significant cardioprotective effect against cyclophosphamide provoked oxidative injury in rats. The significant reductions in the activities of CK-MB and LDH brought about by FRSACE-pretreatment could be due to the presence of racemosic acid (Li et al, 2004), quercetin (Khan & Sultana, 2005), gallic acid and ellagic acid (Rao et al, 2008), which are known to exhibit potent antioxidant activity.…”

Section: Cardioprotective Effectsupporting

confidence: 82%

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Ahmed

Urooj

2011

Pharmaceutical Biology

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Section: Cardioprotective Effectsupporting

confidence: 82%

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Ahmed

Urooj

2011

Pharmaceutical Biology

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“…As a result, CK, CK-MB, LDH, ALT, AST and ALP are released into the blood stream and serve as the diagnostic markers of myocardial tissue damage. [16] The elevated levels of these enzymes are associated with certain types of heart damage such as myocardial infarction, myocarditis and heart failure. The administration of SI showed dose dependent reduction in CP induced elevated biomarkers of cardiac injury.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of Saraca indica against cyclophosphamide induced cardiotoxicity in rats: A biochemical, electrocardiographic and histopathological study

et al. 2013

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Objectives:Cardioprotective activity of alcoholic extract of Saraca indica (SI) bark was investigated against cyclophosphamide induced cardiotoxicity.Materials and Methods:Cardiotoxicity was induced in Wistar rats by administering cyclophosphamide (200 mg/kg, i.p.) single injection on first day of experimental period. Saraca indica (200 and 400 mg/kg, p.o.) was administered immediately after administration of cyclophosphamide on first day and daily for 10 days. The general observations and mortality were measured.Results:Cyclophosphamide administration significantly (p < 0.05) increased lipid peroxidation (LPO) and decreased the levels of antioxidant markers such as reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Cyclophosphamide elevated the levels of biomarker enzymes like creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). Further, the cyclophosphamide treated rats showed changes in electrocardiogram (ECG) along with increased levels of cholesterol and triglycerides. Treatment with Saraca indica significantly (p < 0.05) reversed the status of cardiac biomarkers, ECG, oxidative enzymes and lipid profile in cyclophosphamide induced cardiotoxicity. Potential cardioprotective effect of Saraca indica was supported by histopathological examination that reduced severity of cellular damage of the myocardium.Conclusion:The biochemical, ECG and histopathology reports support the cardioprotective effect of Saraca indica which could be attributed to antioxidant activity.

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“…The marker enzymes such as CK-MB, CK-NAC and LDH were leaked from the myocytes to the blood due to CYP-induced myocardial damage. Hence to detect myocardial necrosis, these marker enzymes were estimated [20].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Mentha Longifolia Against Cyclophosphamide Induced Cardiotoxicity in Rats: A Biochemical, Electrocardiographic and Histopathological Study

R¹,

Karale²,

Kamath³

2016

Int J Pharm Pharm Sci

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Objective: The current research was designed to evaluate the cardioprotective activity of Mentha longifolia (ML) leaf extract on cyclophosphamide-induced cardiotoxicity in rats.Methods: Cardiotoxicity was induced in Albino wistar rats of either sex by administering a single injection of cyclophosphamide (200 mg/kg, i. p.) on the first day of the experimental period. Mentha longifolia (250 and 500 mg/kg, p. o.) was administered daily for 10 d immediately after administration of cyclophosphamide on the first day. The general observations such as oxidative marker enzyme assays, ECG and histopathology were examined.Results: Cyclophosphamide administration significantly (p<0.05) increased lipid peroxidation (LPO) and decreased the levels of antioxidant markers such as superoxide dismutase (SOD) and catalase (CAT). Cyclophosphamide elevated the levels of biomarker enzymes like creatine kinase isoenzyme MB (CK-MB), creatine kinase isoenzyme NAC (CK-NAC) and lactate dehydrogenase (LDH). Further, the cyclophosphamide-treated rats showed changes in electrocardiographic parameters. Treatment with Mentha longifolia significantly (p<0.05) reversed the status of cardiac biomarkers, ECG and oxidative enzymes in cyclophosphamide-induced cardiotoxicity. Histopathological examination was also supported the potential cardioprotective effect of Mentha longifolia with reduced damage to the myocardium.Conclusion: The biochemical, ECG and histopathology reports support the potential benefits of Mentha longifolia against myocardial damage which could be attributed to antioxidant activity.

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Cardioprotective Effect of Ficus hispida Linn. on Cyclophosphamide Provoked Oxidative Myocardial Injury in a Rat Model

Cited by 37 publications

References 49 publications

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Cardioprotective effect of Saraca indica against cyclophosphamide induced cardiotoxicity in rats: A biochemical, electrocardiographic and histopathological study

Cardioprotective Effect of Mentha Longifolia Against Cyclophosphamide Induced Cardiotoxicity in Rats: A Biochemical, Electrocardiographic and Histopathological Study

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