Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity

Abstract

Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be associated with oxidative stress. The aim of the current study is to investigate the role of grape polyphenols’ antioxidant property as cardioprotective against doxorubicin-induced cardiotoxicity. Adult Wistar rats weighing 200 ± 20 g were divided into 3 different groups: a doxorubicin group that received a single intraperitoneal administration of doxorubicin (8.0 mg/kg body weight), an experimental group that received doxorubicin and grape polyphenol concentrate (25 mg/kg) via intragastric route, and the third group was a negative control group that received water only. On day 8, blood samples and tissues were harvested for analyses. The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals. The results also showed that grape polyphenol concentrate was able to reverse doxorubicin-induced microscopic myocardial damage. The myocardial protective effect of grape polyphenol might likely be due to the increase in the level and activity of the antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase. In conclusion, grape polyphenol concentrate displayed cardioprotective effect and was able to reverse doxorubicin-induced-cardiomyopathy in experimental rats.

Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

“…According to the results obtained for the qualitative and quantitative analysis of antioxidants in the present study, important phytochemicals such as polyphenols, alkaloids and tannins were present in ABEC in significant quantities while toxic phytochemicals such as cyanogenic glycosides and cardenoloid glycosides were absent. These results corroborated with many previous findings where the presence of antioxidants such as polyphenols contributed significantly to the protective effect against doxorubicin induced cardiotoxicity ( Kaiserová et al, 2007 , Hamza et al, 2016 , Ojha et al, 2016 , Afsar et al, 2017 , Ibrahim et al, 2017 , Sergazy et al, 2020 ).…”

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

“… 2015 ; Sergazy et al. 2020 ). Importantly, PFPE feeding improved the levels of red blood cells, which may be due to the antioxidant properties of PFPE.…”

“… 2013 , 2017 ; Sergazy et al. 2020 ), we tried to evaluate the effect of PFPE, which consisted of a variety of antioxidants and lowered the toxicity of piperine, in Dox-induced adverse events. This included the haematological and immunological parameters, the specific immune cells associated with antitumor immunity, including Th1, Th2 and Treg cells, and cytokine array analysis.…”

Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response

“…Several studies suggest that the administration of bioactive molecules together with anti-cancer drugs may play a beneficial role in cardiovascular protection due to their pleiotropic antioxidant effect [11,[28][29][30]]. Flavonoids, for example, thanks to their radicalscavenging activity, can be considered highly protective molecules against chronic toxicity caused by Doxo [31][32][33][34].…”