Cardioprotective effect of green tea extract and vitamin E on Cisplatin-induced cardiotoxicity in mice: Toxicological, histological and immunohistochemical studies

Ibrahim, Mahrous A.; Bakhaat, Gamal A.; Tammam, Hany G; Mohamed, Rasha M.S.M.; El‐Naggar, Sabry A.

doi:10.1016/j.biopha.2019.108731

Cited by 42 publications

(32 citation statements)

References 54 publications

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“…Previous studies have reported that CIS activates NF‐κB for its translocation from the cytoplasm to the nucleus where it interacts with κB elements triggering iNOS transcription and expression of IL‐6, IL‐1β and TNF‐α (Kaygusuzoglu et al., 2018; Reuter et al, 2010). Further increased levels of TNF‐α could mediate additional expression of testicular iNOS which herein consequently led to significant increase in NO level corroborating the report of Ibrahim, Bakhaat, Tammam, Mohamed, and El‐Naggar (2019) regarding CIS‐induced NO production via iNOS. The increased testicular level of NO suggests nitrosative stress shown by elevated total nitrite/nitrate represented by NO level, confirmed by upregulation of iNOS expression in the testis.…”

Section: Discussionsupporting

confidence: 88%

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Famurewa¹,

Ekeleme‐Egedigwe²,

Onwe

et al. 2020

Andrologia

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Chemotherapy is a cornerstone option in cancer treatment owing to its efficacy and effect on quality of life of cancer patients. The action mechanism of anticancer agents is targeted at deregulating cell cycle machinery and inhibiting unscheduled proliferation of cancer cells (Lin et al., 2020). Unfortunately, chemotherapeutic anticancer drugs often exert deleterious effect on healthy cells and tissues leading to systemic toxicity (Negrette-Guzmán, 2019). The toxicity may become unbearable that the treatment regimen has to be disrupted, even when achieving tumoricidal efficacy (Lin et al., 2020). Cisplatin (CIS) is an efficacious anticancer agent; it is the first choice for the treatment of advanced nonsmall-cell lung cancer cells, breast cancer and ovarian cancer (Browning et al., 2017; Lin et al., 2020; Manohar & Leung, 2018). It is of significant value also in the treatment of germ cell and testicular cancers (Thurston, 2007). It unleashes its anticancer action through formation of cisplatin-DNA adduct by intrastrand cross-links due to interaction with cancer cell DNA purine bases eventually leading to p53 activation, cell cycle arrest and induction

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Section: Discussionsupporting

confidence: 88%

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Famurewa¹,

Ekeleme‐Egedigwe²,

Onwe

et al. 2020

Andrologia

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“…Consequently, our data showed that the treatment with EDTA and the low dose of Cis significantly improve both of liver and kidney functions when compared to the groups of mice, which treated with the low dose of Cis alone or with the group of mice which inoculated with EAC-cells alone. This finding was in agreement with our previous studies, which showed that the treatment with Cis induces organs toxicity and increased the levels of liver enzymes, urea and creatinine [19,22]. Therefore, co-treatment with EDTA and the low dose of Cis consider a new approach to enhance Cis efficacy and decrease its side effects.…”

Section: Groupssupporting

confidence: 93%

Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice

El‐Naggar

El-Said

Mobasher

et al. 2019

Braz. arch. biol. technol.

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In a recent study, the treatment of different human cancer cell lines in vitro with ethylene diamine tetra-acetic acid (EDTA) showed a promising anticancer activity which could be a novel promising approach for cancer treatment. The aim of this study is to address the ability of EDTA to enhance the antitumor efficacy of the low dose of cisplatin (Cis) treatment in Ehrlich ascetic carcinoma (EAC) bearing mice. Sixty female albino mice were divided into six groups. The 1 st group of mice was served as a negative control. 2 nd -6 th groups were inoculated intraperitoneal (i.p) with 2×10 6 EAC cells/mouse. After one day of inoculation, the 2 nd , 3 rd and 4 th groups were injected daily for 6 days (early treatment) with phosphate buffer saline, low dose of Cis and Cis/EDTA, respectively. After six days, the 5 th and 6 th groups were injected with the low dose of Cis and Cis/EDTA for 6 consecutive days (late treatment), respectively. At day 14, all groups of mice were sacrificed, sera were collected for biochemical assessment, HIGHLIGHTS• EDTA enhanced the antitumor efficacy of the low dose of Cisplatin.• Low dose of Cisplatin did not inhibit tumor growth • Co-treatment with EDTA delayed and decreased tumor growth.• EDTA decreased the toxicity of Cisplatin. 2 El-Naggar, S.A.; et al.

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“…After 1-week acclimation, rats were allocated into 5 groups each contains 6 rats; they were treated as follows: the first group was served as the normal control group and administered distilled water; in the second group, rats were intoxicated subcutaneously with 5 mg/kg HgCl 2 15 once daily; the rats in the third group were treated with Vit-E at a dose of 100 mg/kg/day, orally 16 ; the fourth group was orally treated with 6 × 10 10 CFU of Lac-B 1.8701/kg in 1 mL normal saline 17 ; and the fifth group was treated with the combination of Vit-E and Lac-B. All treatments were given daily along with HgCl 2 for 2 weeks.…”

Section: Methodsmentioning

confidence: 99%

Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl₂: Role of CHOP, GPR87, and mTOR Proteins

et al. 2021

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Background and Objective: Mercury is one of the most harmful heavy metals and its toxicity causes severe multi-organ dysfunction. This study was designed to explore novel molecular pathways involved in the hepatoprotective effect of vitamin E (Vit-E) and Lactobacillius plantarum (Lac-B) against mercury toxicity.[Formula: see text] Method: Acute hepatotoxicity was induced by administration of high dose of mercuric chloride (HgCl2) in male rats, Vit-E or/and Lac-B were given along with HgCl2 for 2 weeks. The effects of those antioxidants were studied focusing on their anti-apoptotic, anti-oxidative stress and anti-inflammatory eficacies. Histopathological examinations were also conducted. Results: The administration of HgCl2 induced liver injury which manifested by elevation in serum ALT and AST. Liver MDA, caspase-3 and TNF-α levels were markedly increased; whereas, GSH level and SOD activity were declined. HgCl2 significantly elevated the expressions of hepatic CHOP, GPR87, NF-κB and mTOR. Histopathological examination revealed massive hepatocyte degeneration following HgCl2 administration. Treatment with Vit-E or/and Lac-B restored the normal levels of the previously mentioned parameters, as well as improved hepatic architecture. Conclusion: Vit-E and Lac-B provided protective effect against HgCl2-induced hepatotoxicity via reduction of oxidative stress and inflammation, and downregulation of CHOP, GPR87, NF-κB and mTOR proteins’ expressions.

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Cardioprotective effect of green tea extract and vitamin E on Cisplatin-induced cardiotoxicity in mice: Toxicological, histological and immunohistochemical studies

Cited by 42 publications

References 54 publications

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice

Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl₂: Role of CHOP, GPR87, and mTOR Proteins

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Cardioprotective effect of green tea extract and vitamin E on Cisplatin-induced cardiotoxicity in mice: Toxicological, histological and immunohistochemical studies

Cited by 42 publications

References 54 publications

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice

Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl2: Role of CHOP, GPR87, and mTOR Proteins

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Product

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Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl₂: Role of CHOP, GPR87, and mTOR Proteins