Cardioprotective Effect of Naringin in Mice Treated with Doxorubicin

Reddy, Tiyagura Koti; Nagaraju, I.; Kumar, K. Hemanth; Valluru, Lokanatha; Reddy, C. Devendranath; Jagetia, Ganesh Chandra

doi:10.1055/s-2008-1075245

Cited by 13 publications

(9 citation statements)

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“…Naringin supplementation also reduced lipid peroxidation, improved antioxidant enzymes, and decreased inflammatory cell and fibrosis in hearts of isoproterenol-treated rats (70). Pretreatment with various doses of naringin inhibited the doxorubicin-induced decline in antioxidant status and reduced the concentrations of 8-OHdG and the activity of poly (ADP-ribose) polymerase (PARP) in heart and liver of mice (71). Oral pretreatment with naringin (10, 20, and 40 mg/kg) in isoproterenol-induced rats daily for a period of 56 d significantly (P < 0.05) minimized the alterations in mitochondrial tricarboxylic acid cycle enzymes (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and a-ketoglutarate dehydrogenase) and respiratory chain enzymes (NADH dehydrogenase and cytochrome c oxidase) (72).…”

Section: Effect Of Naringin On Cardiac Toxicity Hypertrophy and Remmentioning

confidence: 93%

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Alam¹,

Subhan²,

Rahman³

et al. 2014

Advances in Nutrition

615

340

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Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.

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Section: Effect Of Naringin On Cardiac Toxicity Hypertrophy and Remmentioning

confidence: 93%

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Alam¹,

Subhan²,

Rahman³

et al. 2014

Advances in Nutrition

615

340

View full text Add to dashboard Cite

show abstract

“…[ 17 20 34 35 36 ] Naringin exhibits a potential cardio-protective effect through modulation of oxidative stress and inflammatory markers in doxorubicin as well as isoproterenol induced cardiotoxicity. [ 37 38 ] It has been reported that naringin revealed protective effect on glycerol-induced acute renal failure in rat kidney. [ 39 ] It has been supported that naringin exerts its renoprotective effect in ischemia reperfusion injury in rats conceivably due to overwhelming antioxidant proficiency and free radical scavenging activity.…”

mentioning

confidence: 99%

Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats

et al. 2015

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Background:Renal artery occlusion (RAO) induced hypertension is a major health problem associated with structural and functional variations of the renal and cardiac vasculature. Naringin a flavanone glycoside derived possesses metal-chelating, antioxidant and free radical scavenging properties.Objective:The objective of this study was to investigate the antihypertensive activity of naringin in RAO induced hypertension in rats.Material and Methods:Male Wistar rats (180-200 g) were divided into five groups Sham, RAO, naringin (20, 40 and 80 mg/kg). Animals were pretreated with naringin (20, 40 and 80 mg/kg p.o) for 4 weeks. On the last day of the experiment, left renal artery was occluded with renal bulldog clamp for 4 h. After assessment of hemodynamic and left ventricular function various biochemical (superoxide dismutase [SOD], glutathione [GSH] and malondialdehyde [MDA]) and histological parameters were determined in the kidney.Results:RAO group significantly (P < 0.001) increased hemodynamic parameters at 15, 30 and 45 min of clamp removal. Naringin (40 and 80 mg/kg) treated groups showed a significant decrease in hemodynamic parameters at 15 min. after clamp removal that remained sustained for 60 min. Naringin (40 and 80 mg/kg) treated groups showed significant improvement in left ventricular function at 15, 30 and 45 min after clamp removal. Alteration in level of SOD, GSH and MDA was significantly restored by naringin (40 and 80 mg/kg) treatment. It also reduced histological aberration induced in kidney by RAO.Conclusion:It is concluded that the antihypertensive activity of naringin may result through inhibition of oxidative stress.

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“…is group was also given the corresponding amount of 1% CMC (5 mL/kg b.wt) orally every other day for six weeks. (3) Paclitaxel-administered group treated with naringin: rats were administered paclitaxel intraperitoneally as in group 2 and received oral naringin 10 mg/kg b.wt treatment [39] every other day for six weeks (dismantled in 5 mL 1% CMC). (4) Paclitaxel-administered group treated with naringenin: rats were treated as above but were administered naringenin at a dose level 10 mg/kg b.wt [40] (dismantled in 5 mL 1% CMC) instead of naringin every other day for six weeks.…”

Section: Experimental Designmentioning

confidence: 99%

The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

Khaled

Soliman

Abdel‐Gabbar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure.

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Cardioprotective Effect of Naringin in Mice Treated with Doxorubicin

Cited by 13 publications

References 0 publications

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats

The Preventive Effects of Naringin and Naringenin against Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

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