Cardioprotective effect of pentacyclic triterpene, lupeol and its ester on cyclophosphamide-induced oxidative stress

Abstract

<jats:p> Cyclophosphamide (CP), an alkylating agent widely used in cancer chemotherapy, causes fatal cardiotoxicity. In the present study, lupeol, a pentacyclic triterpene, isolated from Crataeva nurvala stem bark and its ester, lupeol linoleate were investigated for their possible cardioprotective effects against CP-induced toxicity. Male albino rats of Wistar strain were injected with a single dose of CP (200 mg/kg body weight, ip). In CP-administered rats, activities of lactate dehydrogenase and creatine phosphokinase were elevated in serum with a concomitant decline in their activities in the cardiac tissue. Significant increases (P B &lt; 0.001) in the levels of lipid peroxides and a decrease (P B &lt; 0.001) in the levels of enzymic (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and glutathione-s-transferase) and nonenzymic (reduced glutathione, vitamin C and vitamin E) antioxidants in the heart were also observed. The cardioprotective effects of lupeol (50 mg/kg body weight for 10 days orally) and its ester, lupeol linoleate (50 mg/kg body weight for 10 days orally) were evident from the significant reversal of the above alterations induced by CP. These observations highlight the antioxidant property of triterpenes and their cytoprotective action against CPinduced cardiotoxicity. </jats:p>

Male infertility testing: reactive oxygen species and antioxidant capacity

“…Rapidly dividing spermatogonia are more sensitive to damage compared with later stage cells. Commonly used chemotherapy agents that have gonadotoxic properties include cisplatin (73), cyclophosphamide (74), and doxyrubicin (75). Heat shock proteins may facilitate the testicular OS response (76).…”

Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFκB/MAPK pathway

“…Therefore amalgamation of treatment regimen with effective antioxidants might be the desirable approach to alleviate the toxicity induced by CP [21,22]. Various studies have reported that plant extracts possessing antioxidant activity protect against hepatotoxicity induced by CP [23,24].…”

Aegle marmelos (L.) Correa (Bael) and Its Phytochemicals in the Treatment and Prevention of Cancer

“…44,45 Lupeol alleviated the cyclophosphamideinduced increase in the activities of lysosomal hydrolases in serum and heart, and concomitantly increased the levels of cellular thiols. 46 Lupeol increased the activities of TCA cycle enzymes and mitochondrial complexes of electron transport chain in the cardiac tissue 47 and normalized the activities of ATPases, urea, uric acid, and creatinine.…”