Cardioprotective Effect of Rhizomes of Acorus gramineus Against Isoproterenol-Induced Cardiac Damage in Pigs

Kim, Jong-Hoon; Chung, Hwan‐Suck; Antonisamy, Paulrayer; Lee, Seung Ryel; Bae, Hyunsu

doi:10.1007/s12012-014-9243-5

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…This demonstrates that the water extract of the rhizomes of A. gramineus has significant cardiac protection potential and may be used to treat and prevent myocardial infarction [138]. The aqueous-methanolic extract of A. calamus has a therapeutic effect on ischemic heart disease mainly through the endothelium-dependent hyperpolarizing factor, which can regulate the coronary vasodilation effect and promote an increase in coronary blood flow [139].…”

Section: Cardiac Protection Activitymentioning

confidence: 95%

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Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review

Zhao,

Li,

Cao

et al. 2023

Molecules

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The genus Acorus, a perennial monocotyledonous-class herb and part of the Acoraceae family, is widely distributed in the temperate and subtropical zones of the Northern and Southern Hemispheres. Acorus is rich in biological activities and can be used to treat various diseases of the nervous system, cardiovascular system, and digestive system, including Alzheimer’s disease, depression, epilepsy, hyperlipidemia, and indigestion. Recently, it has been widely used to improve eutrophic water and control heavy-metal-polluted water. Thus far, only three species of Acorus have been reported in terms of chemical components and pharmacological activities. Previously published reviews have not further distinguished or comprehensively expounded the chemical components and pharmacological activities of Acorus plants. By carrying out a literature search, we collected documents closely related to Acorus published from 1956 to 2022. We then performed a comprehensive and systematic review of the genus Acorus from different perspectives, including botanical aspects, ethnic applications, phytochemistry aspects, and pharmacological aspects. Our aim was to provide a basis for further research and the development of new concepts.

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Section: Cardiac Protection Activitymentioning

confidence: 95%

“…The crude extract of A. calamus has the effect of dilating coronary vessels, which provides a basis for the treatment of ischemic heart disease [139]. The essential oil of A. calamus has the effect of anti-atrial fibrillation, atrial fibrillation, ventricular arrhythmia, etc.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review

Zhao,

Li,

Cao

et al. 2023

Molecules

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“…VOA also showed great potential in the treatment of myocardial infarction. Jong-Hoon Kim et al (2014) found that VOA significantly improved the ISO-induced cardiac dysfunction. In addition, taking VOA can significantly reduce the increase of cardiac injury markers such as cardiac troponin T, tumour necrosis factor, myeloperoxidase activity and cardiac marker enzyme and prevent the consumption of antioxidant parameters.…”

Section: Pharmacological Activities and Mechanisms Of Volatile Oil Of...mentioning

confidence: 99%

Advances in extraction methods, chemical constituents, pharmacological activities, molecular targets and toxicology of volatile oil from Acorus calamus var. angustatus Besser

Bai

Wang

et al. 2022

Front. Pharmacol.

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Acorus calamus var. angustatus Besser (ATT) is a traditional herb with a long medicinal history. The volatile oil of ATT (VOA) does possess many pharmacological activities. It can restore the vitality of the brain, nervous system and myocardial cells. It is used to treat various central system, cardiovascular and cerebrovascular diseases. It also showed antibacterial and antioxidant activity. Many studies have explored the benefits of VOA scientifically. This paper reviews the extraction methods, chemical components, pharmacological activities and toxicology of VOA. The molecular mechanism of VOA was elucidated. This paper will serve as a comprehensive resource for further carrying the VOA on improving its medicinal value and clinical use.

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“…in male pigs possesses significant cardioprotective potential against isoproterenol-induced myocardial infarction as it significantly attenuated increased cardiac injury markers, such as cardiac troponin T, tumor necrosis factor (TNF)-α, and myeloperoxidase activity, and cardiac marker enzymes, and prevented the depletion of antioxidant parameters [11]. 4.…”

Section: The Administration Of Water Extract Of Rhizomes Of Acorus Grmentioning

confidence: 99%

Current Pharmacological Status of Cardioprotective Plants Against Isoproterenol Induced Myocardial Infarction

Fathima

S²

2018

Asian J Pharm Clin Res

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Objective: Cardiovascular diseases are the major cause of morbidity and mortality in the modern era. Myocardial infarction is a condition where there is a significant decrease or block in the blood (oxygen) supply to the part of heart, leading to degeneration of a portion of the myocardium which triggers a cascade of cellular, inflammatory and biochemical events, leading eventually to the irreversible death (necrosis) of heart muscle cells. Various therapeutic interventions, including lifestyle modification, pharmacological treatment options, and surgical techniques are available. The present review focus on the plants that have been evaluated for cardioprotective activity against isoproterenol-induced myocardial infarction.Method: The current status of Cardioprotective plants was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 2017 for publications on medicinal plants used against isoproterenol-induced myocardial infarction. Isoproterenol, Isoprenaline, myocardial infarction, cardioprotective were used as keywords for the searching.Result: A total of 117 different plant parts and their extracts have till now been published to possess cardioprotection against isoproterenol-induced myocardial infarction. Isoproterenol a beta-adrenergic receptors agonist causes severe stress in myocardium resulting in the infarct-like lesion and produced cardiotoxic effects by elevating the levels of cardiac biomarkers and causing changes in ECG. Plant-based medicines with their antioxidant, antiapoptotic, antihyperlipidemic, platelet antiaggregatory, anti-lipid peroxidation property provide substantial evidence for the management of Ischemia.Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of plants that have cardioprotective activity against isoproterenol-induced myocardial infarction.

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Cardioprotective Effect of Rhizomes of Acorus gramineus Against Isoproterenol-Induced Cardiac Damage in Pigs

Cited by 8 publications

References 48 publications

Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review

Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review

Advances in extraction methods, chemical constituents, pharmacological activities, molecular targets and toxicology of volatile oil from Acorus calamus var. angustatus Besser

Current Pharmacological Status of Cardioprotective Plants Against Isoproterenol Induced Myocardial Infarction

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