Cardioprotective effect of Urtica parviflora leaf extract against doxorubicin-induced cardiotoxicity in rats

Barman, Nishith Ranjan; Kar, Prasanna Kumar; Hazam, Prakash K.; Pal, Himadri S.; Kumar, A Anand; Bhattacharya, Sanjib; Haldar, Pallab Kanti

doi:10.1016/s1875-5364(13)60005-9

Cited by 4 publications

(7 citation statements)

References 28 publications

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“…31 Malondialdehyde, end-product of lipid peroxidation, is further elevated by overproduction of free radicals which in turn reduces the antioxidant enzymes and increases disturbance of calcium influx induced by toxic agents. 3 In this study, doxorubicin significantly reduced heart levels GSH, CAT and GPx relative to control, thereby indicating cardiotoxicity. This is in accordance with previous research findings by Saad et al 32 that documented decreases in GSH, GPx and CAT levels.…”

Section: Resultssupporting

confidence: 48%

“…Flavonoids and tannins are well known polyphenolic natural antioxidants. 3 Phenols have been found to be very effective in preventing the build-up of damaging cholesterol. 40…”

Section: Resultsmentioning

confidence: 99%

“…The ratio of male: female rats was equal across the different groups. 3 I. asarifolia extract and gallic acid were given p.o. for 21 days.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…However, its clinical use very often becomes a limiting factor in anticancer therapy due to high irreversible cardiotoxicity. 3 Oxidative stress, lipid peroxidation and mitochondrial dysfunction have been associated with DOX-induced cardiomyopathy. 4 Doxorubicin accumulates mainly in the kidney and to a lesser extent in the liver, heart and small intestine.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Hydroethanolic Leaf Extract of Ipomoea asarifolia (Convolvulaceae) in Doxorubicin and Isoproterenol-Induced Toxicity in Rats

Akindele¹,

Palmer²

2018

TJNPR

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This study investigated the effects of the hydroethanolic leaf extract of Ipomoea asarifolia on doxorubicin and isoproterenol-induced toxicities in rats. Rats were randomly assigned into groups-Group 1: distilled water (10 mL/kg orally), Group 2: toxicant, Groups 3-5: I. asarifolia (100, 200 and 400 mg/kg orally, respectively) and toxicant, and Group 6: gallic acid (15 mg/kg orally) and toxicant. Treatment lasted for 21 days in the doxorubicin (DOX) model and DOX (5 mg/kg intraperitoneally) was administered on days 7, 14 and 21. Treatment was carried out for 30 days in the isoproterenol (ISO) model and ISO (85 mg/kg subcutaneously) was administered on days 28-30. A day after the treatment, blood samples were collected for biochemical analysis and animals were sacrificed. Vital organs were harvested for in-vivo antioxidants assay. In the DOX model, I. asarifolia (100-400 mg/kg) produced significant (p < 0.01) reduction in levels of lactate dehydrogenase (LDH) and triglycerides (TG) relative to the DOX group. The extract reversed the diminution in heart reduced glutathione (GSH) level caused by DOX. ISO significantly increased (p < 0.001) levels of LDH and TG, but these effects were reversed by I. asarifolia (100 and 400 mg/kg). The extract (400 mg/kg) significantly reversed (p < 0.01) the increase in kidney MDA level elicited by ISO. I. asarifolia (200 and 400 mg/kg) significantly (p < 0.001) reversed the increase in liver MDA and reduction in CAT levels elicited by ISO. These findings suggest that the extract possesses cardioprotective effects against doxorubicin and isoproterenol-induced toxicities.

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Section: Resultssupporting

confidence: 48%

“…Flavonoids and tannins are well known polyphenolic natural antioxidants. 3 Phenols have been found to be very effective in preventing the build-up of damaging cholesterol. 40…”

Section: Resultsmentioning

confidence: 99%

“…The ratio of male: female rats was equal across the different groups. 3 I. asarifolia extract and gallic acid were given p.o. for 21 days.…”

Section: Experimental Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Hydroethanolic Leaf Extract of Ipomoea asarifolia (Convolvulaceae) in Doxorubicin and Isoproterenol-Induced Toxicity in Rats

Akindele¹,

Palmer²

2018

TJNPR

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“…Histopathological studies: Hearts were removed from the experimental animals and kept in 10 % formalin solution. The isolated heart is then processed for section cutting is about 5 µm thickness by using microtome and stained with hematoxylin and eosin (H and E) reagents and observed by light microscope to evaluate myocardium injury [13].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Flavonoid from Methanolic Extract of Mirabilis jalapa Linn. Tuber and Evaluation of its Cardioprotective Property

Shil¹,

Dash²,

Laloo³

et al. 2018

Asian J. Chem.

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The aim of the study is to isolate and characterization of bioconstituent present in methanolic extract of Mirabilis jalapa L. tuber and also evaluate the cardioprotective property of the extract as well as isolated compound from the extract. The bioactive constituent flavonoid was isolated from methanolic extract through flash chromatography technique by using solvent system ethyl acetate and methanol. The chemical structure of compound was confirmed on the basis of spectroscopy analysis and identified as 2-(3′, 4′-dihydroxy phenyl)-3,5,7trihydroxy chromen 4-one. Administration of Mirabilis jalapa extract in higher dose 200 and 400 mg/kg b.w. and isolated compound to doxorubicin-intoxicated rats demonstrated prominent reduction in serum biomarker enzymes, normalization of serum lipid profiles. Also, significant modulation of malondialdehyde (MDA), endogenous non-enzymatic (GSH) and enzymatic (SOD and CAT) antioxidant and detoxification systems compared to doxorubicin control rats. This was achieved due to presence of flavonoid in the methanolic extract of Mirabilis jalapa L. tuber.

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Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicity

Saleem

Chetty²,

Kavimani³

2014

Therapeutic Advances in Cardiovascular Disease

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Cardioprotective effect of Urtica parviflora leaf extract against doxorubicin-induced cardiotoxicity in rats

Cited by 4 publications

References 28 publications

Effects of Hydroethanolic Leaf Extract of Ipomoea asarifolia (Convolvulaceae) in Doxorubicin and Isoproterenol-Induced Toxicity in Rats

Effects of Hydroethanolic Leaf Extract of Ipomoea asarifolia (Convolvulaceae) in Doxorubicin and Isoproterenol-Induced Toxicity in Rats

Isolation and Characterization of Flavonoid from Methanolic Extract of Mirabilis jalapa Linn. Tuber and Evaluation of its Cardioprotective Property

Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicity

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