Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

Kamisah, Yusof; Periyah, Vengadesh; Lee, Kee Tat; Noor-Izwan, Norrashid; Nurul-Hamizah, Amran; Nurul-Iman, Badlishah Sham; Subermaniam, Kogilavani; Jaarin, Kamsiah; Azman, Azreen; Othman, Faizah; Qodriyah, Hj Mohd Saad

doi:10.3109/13880209.2014.971383

Cited by 27 publications

(13 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data show that acute administration of LA reduces blood pressure followed by bradycardia in both normotensive Wistar Kyoto and spontaneously hypertensive rats. Previous studies reported that coconut oil, a LA‐rich oil, is able to reduce the blood pressure and exerts cardioprotective effects due to its antioxidant activity . Supporting this proposal, our group have documented that coconut oil (2 mL/day during 30 days) improves the baroreflex sensitivity and reduces the oxidative stress in hypertensive rats .…”

Section: Discussionsupporting

confidence: 63%

Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats

Alves

Queiroz

Travassos

et al. 2017

Basic Clin Pharma Tox

View full text Add to dashboard Cite

The effects of acute administration of lauric acid (LA), the most abundant medium-chain fatty acid of coconut oil, on blood pressure, heart rate and oxidative stress were investigated in spontaneously hypertensive rats (SHR). Intravenous doses of LA reduced blood pressure in a dose-dependent fashion (1, 3, 4, 8 and 10 mg/kg) in both SHR and Wistar Kyoto rats. LA (10 to 3 × 10 M) induced vasorelaxation in isolated superior mesenteric artery rings of SHR in the presence (n = 7) or absence (n = 8) of functional endothelium [maximum effect (ME) = 104 ± 3 versus 103 ± 4%]. After exposure to KCl (60 mM), LA also induced concentration-dependent vasorelaxation (n = 7) compared to that under Phe-induced contraction (ME = 113.5 + 5.1 versus 104.5 + 4.0%). Furthermore, LA-induced vasorelaxation in vessels contracted with S(-)-BayK8644 (200 nM), a L-type Ca channel agonist (ME = 91.4 + 4.3 versus 104.5 + 4.0%, n = 7). Lastly, LA (10 M) reduced NADPH-dependent superoxide accumulation in the heart (18 ± 1 versus 25 ± 1 MLU/min/μg protein, n = 4, p < 0.05) and kidney (82 ± 3 versus 99 ± 4 MLU/min/μg protein, n = 4, p < 0.05). Our data show that LA reduces blood pressure in normotensive and hypertensive rats. In SHR, this effect might involve Ca channels in the resistance vessels and by its capability of reducing oxidative stress in heart and kidneys.

show abstract

Section: Discussionsupporting

confidence: 63%

Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats

Alves

Queiroz

Travassos

et al. 2017

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…Within the above‐mentioned studies, the oil type and the content of FAs in the respective control group varied. Studies that compared the effects of oils to a control diet incorporated similar lipid content as our CTRL diet and did not show any significant alterations in the biochemical or CV parameters …”

Section: Discussionmentioning

confidence: 99%

“…54,55 Some studies of clinical endpoints suggest that PUFA, and α-linolenic acid (ALA) in particular, can have CV benefits; however, overall evidence remains mixed and inconclusive. 7,56,57 Virgin coconut oil is one of the plant products, which proved to have a beneficial impact on the CV system, by preventing blood pressure from rising and normalizing the lipid profile, 58 when compared to other oils such as copra oil 59 or sunflower oil. 60 In our study, except for the EP group, that exhibited a significantly elevated level of TGs, the diets did not influence the biometric, biochemical, and CV parameters, which were within the normal range of variation (similar to CTRL).…”

Section: Discussionmentioning

confidence: 99%

“…Studies that compared the effects of oils to a control diet incorporated similar lipid content as our CTRL diet and did not show any significant alterations in the biochemical or CV parameters. 47,50,58,61 The function of WAT and colon can be affected by changes in dietary fat intake. Both SOY and EP diets displayed cellular hypertrophy, compared with the CTRL group, shown as a decrease in the number of adipocytes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Mosińska

Martín‐Ruíz

González

et al. 2019

Neurogastroenterology Motil

View full text Add to dashboard Cite

Background Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity. Methods Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO), and SOY + 3.5% evening primrose oil (EP) for 4 weeks. The content of insoluble fiber in CTRL was higher than in SOY, COCO, or EP. Body weight gain and food/water intake were measured. At day 28, biometric, biochemical, CV parameters, GI motor function (X‐ray and colon bead expulsion test), and visceral sensitivity were evaluated. Changes in propulsive colonic activity were determined in vitro. The colon and adipose tissue were histologically studied; the number of mast cells (MCs) in the colon was calculated. Results SOY, COCO, and EP had increased body weight gain but decreased food intake vs CTRL. Water consumption, biometric, biochemical, and CV parameters were comparable between groups. SOY increased the sensitivity to colonic distention. All groups maintained regular propulsive neurogenic contractions; EP delayed colonic motility (P < 0.01). SOY, COCO, and EP displayed decreased size of the cecum, lower number and size of fecal pellets, and higher infiltration of MCs to the colon (P < 0.001). Conclusions and Inferences Dietary FAs supplementation and lower intake of insoluble fiber can induce changes in the motility of the lower GI tract, in vivo and in vitro, but CV function and visceral sensitivity are not generally affected.

show abstract

“…Our previous study also demonstrated the mitigating potential of VCO on HAART‐induced testicular ravages (Ogedengbe et al ., ). Other health benefits of VCO include neuroprotective and memory enhancing abilities (Rahim et al ., ), a cardioprotective potential (Kamisah et al ., ), antidiabetic capacity (Akinnuga et al ., ), hepatoprotective potential (Zakaria et al ., ), and ability to help reduce body weight (Gunasekaran et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

et al. 2018

View full text Add to dashboard Cite

The consumption of alcohol by people living with HIV/AIDS is associated with a graver prognosis. Long-term use of antiretrovirals may have certain health challenges that may be aggravated by concomitant alcohol use. This study investigated virgin coconut oil (VCO) as an adjuvant to the deleterious effects of highly active antiretroviral therapy (HAART) and alcohol on the cyto-architecture and functioning of the testis. Forty adult male Sprague-Dawley rats, weighing 165~176 g, were divided into eight groups and treated according to protocol. Testicular histology, stereological parameters, seminal fluid, testosterone, luteinizing hormone, follicle-stimulating hormone, the antioxidants marker malondialdehyde (MDA), and antioxidant glutathione (GSH) were examined. The use of ethanol alone and ethanol + HAART showed extensive degeneration in the seminiferous epithelium, decreased semen quality, disorganized basement membrane and widened, hypocellular interstitium. GSH was significantly decreased in the ethanol alone treated group with no significant effect on testosterone, LH, and MDA levels. Adjuvant treatment with VCO at low dose (2.5 mL/kg/bw) improved sperm motility with a partial restoration of the histopathological alterations. High doses of VCO (5.0 mL/kg/bw) showed greater improvement with respect to sperm counts, increased FSH hormonal and GSH antioxidant levels, and a well-preserved testicular cyto-architecture.

show abstract

Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

Abstract: These results suggested that VCO supplementation possesses a cardioprotective effect by preventing the increase in blood pressure via an antioxidant mechanism and remodeling in rats fed repeatedly with a HPO diet.

Cited by 27 publications

References 37 publications

Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats

Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy

Contact Info

Product

Resources

About