Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: Effects on serum lipid profiles and blood pressure

Kim, Eun Young; Baek, In-Hee; Rhyu, Mee-Ra

doi:10.1016/j.jep.2011.01.019

Cited by 17 publications

(13 citation statements)

References 52 publications

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“…Schizandrin B and C are components of SC extract (Xu et al, 2011). Schizandrin B has been used to treat vascular injury (Chiu et al, 2004;Kim et al, 2011;Park et al, 2012) and schizandrin C has been reported to induce leukemia cell death (Park et al, 2009), and the deaths of human cancer cell lines (Min et al, 2008;Yasukawa et al, 1992). However, the underlying pharmacological mechanisms of SC extract are not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Schizandra chinensisextracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway

Kim

Lee

Park

et al. 2014

Pharmaceutical Biology

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Objectives: This study investigates the mechanism of SCE-induced apoptosis in AGS human gastric cancer cells. Materials and methods: SCE concentrations from 100 to 400 mg/ml were used. Cell viabilities were determined using MTT assay. Members of the Bcl-2 family and Bax were detected by Western blotting. RT-PCR was performed to measure the expression level of the Fas/FasL pro-apoptotic genes.Results: SCE inhibited the proliferation AGS cells for 24 or 72 h (inhibition by 3.1% ± 5.2% at 100 mg/ml and 87.3% ± 7.6% at 400 mg/ml at 24 h and by 40.2% ± 5.3% 100 mg/ml and 95.3% ± 1.3% 400 mg/ml at 72 h) and increased the sub-G1 phase (25.3% ± 5.2% at 100 mg/ml and 370.2% ± 7.2% at 400 mg/ml) and the mitochondrial membrane depolarization (11.2% ± 2.1% at 100 mg/ml and 311.5% ± 6.1% at 400 mg/ml). The SCE-induced apoptotic cell death showed the down-regulation of Bcl-2, but up-regulation of Bax. Subsequently, SCE increased the expression level of Fas/FasL, activated caspase-9 and -3, and increased reactive oxygen species generation. Also, JNK II inhibitor or a p38 MAPK inhibitor inhibited SCE-induced cell death. Discussion and conclusion: These results indicate that SCE might be an effective chemotherapeutic for the treatment of human gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Schizandra chinensisextracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway

Kim

Lee

Park

et al. 2014

Pharmaceutical Biology

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“…Sour and salty components are believed to have good effects on the liver and testicles, bitter and stringent ones are believed to have good effects on the heart and lungs, and sweet component is believed to have good effects on the stomach [22]. In addition, numerous clinical trials have reported the efficacy of SF in conditions such as cough, dyspnea, dysentery, insomnia, amnesia, tumor, CNS, and cardiotonic disorder [18, 50, 51]. In Korea, SF is used in various herbal prescriptions for the treatment of menopausal symptoms, including Pheongbojinsimdan, Gamiondamtang, and Insugsan [18].…”

Section: Discussionmentioning

confidence: 99%

“…SF comprises sweet (fruit skin), sour (pulp), bitter/pungent (seed core), and salty components (all parts) [18, 19]. According to previous studies, It can also be used as antioxidant [20], antitumor [21], and antiaging agent [22] and in the treatment of liver diseases [23].…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, It can also be used as antioxidant [20], antitumor [21], and antiaging agent [22] and in the treatment of liver diseases [23]. In Korea, SF has been used in various herbal prescriptions for treating menopausal symptoms [18]. The objective of this study was to analyze the effects of SF on menopausal symptoms in VCD-induced ovarian failure mice model.…”

Section: Introductionmentioning

confidence: 99%

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Schisandrae Fructus Reduces Symptoms of 4‐Vinylcyclohexene Diepoxide‐Induced Ovarian Failure in Mice

Shin

Hong³

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer's disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4-vinylcyclohexene diepoxide (VCD) in mice. VCD directly targets the preantral follicles. Mice were injected with VCD (160 mg/kg intraperitoneally) daily for 15 days and then with SF dosage 3 times/week for six weeks. To evaluate the effects of SF, body weight, tail skin temperature, uterine weight, lipid profile, and osteocalcin levels were measured. A decrease in body weight and tail skin temperature and an increase in uterine weight were observed upon SF treatment. Moreover, SF treatment significantly decreased total cholesterol, triglyceride, osteocalcin, and low-density lipoprotein levels and low-density/high-density lipoprotein ratio. These results suggest the potential use of SF in the treatment of menopausal symptoms in women.

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“…[5][6][7][8] The potential mechanism underlying the cardioprotective effects of Sch B has been considered as the high antioxidant potential both in vitro and in vivo. [9][10][11] Recent studies have further indicated that Sch B could improve cardiac function and attenuate myocardial remodeling in the MI mice model through Systemically administered nanoscale drug carriers could improve the solubility of hydrophobic drugs, prolong circulation half-life, and passively improve the accumulation of therapeutic agents in the target area. 2,14 Several researches have proven that the bioactivity of Sch B was improved using nanotechnology such as phospholipid complex loaded nanoparticles, and folate-targeted and polyethylene glycol (PEG)-modified (PEGylated) TiO 2 nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles

Shao¹,

Yang²,

Han³

2017

IJN

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Purpose Schisandrin B (Sch B) is clinically applied for the treatment of hepatitis and ischemic disease. However, its clinical efficacy is limited due to the poor solubility and low bioavailability. This study aimed to develop matrix metalloproteinase (MMP)-sensitive peptide-modified, polyethylene glycol (PEG)-modified (PEGylated) solid lipid nanoparticles (SLNs) for loading Sch B (MMP-Sch B SLNs), and to evaluate the therapeutic effect in the myocardial infarction model. Methods PEG lipid and MMP-targeting peptide conjugate were synthesized. MMP-Sch B SLNs were prepared by solvent displacement technique. The physicochemical properties and pharmacokinetics of SLNs were investigated. In vivo effects on infarct size was evaluated in rats. Results The successful synthesis of lipid-peptide conjugate was confirmed. MMP-Sch B SLNs had a particle size of 130 nm, a zeta potential of 18.3 mV, and a sustained-release behavior. Higher heart drug concentration and longer blood circulation times were achieved by Sch B loaded SLNs than the drug solution according to the pharmacokinetic and biodistribution results. The best therapeutic efficacy was exhibited by MMP-Sch B SLNs by reducing the infarction size to the greatest extent. Conclusion The modified SLNs may be a good choice for delivery of Sch B for the treatment of myocardial infarction.

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Cardioprotective effects of aqueous Schizandra chinensis fruit extract on ovariectomized and balloon-induced carotid artery injury rat models: Effects on serum lipid profiles and blood pressure

Cited by 17 publications

References 52 publications

Schizandra chinensisextracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway

Schizandra chinensisextracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway

Schisandrae Fructus Reduces Symptoms of 4‐Vinylcyclohexene Diepoxide‐Induced Ovarian Failure in Mice

Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles

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