Cardioprotective effects of benazepril, an angiotensin-converting enzyme inhibitor, in an ischaemia-reperfusion model of myocardial infarction in rats

Abstract

Introduction. The present study evaluated the effects of benazepril, an angiotensin-converting enzyme inhibitor on haemodynamic, biochemical, and immunohistochemical (Bax and Bcl-2 protein) indices in ischaemia and reperfusion (IR) injury. Materials and methods. Male Wistar albino rats were divided into three groups and were orally administered saline once daily (IR-sham and IR-control) or benazepril (30 mg/kg/day; IR-benazepril) for 14 days. On the 15 th day, in the IR-control and IR-benazepril groups, rats were subjected to left anterior descending coronary artery occlusion for 45 minutes followed by a one-hour reperfusion. Haemodynamic parameters were recorded and rats were sacrificed; hearts were isolated for biochemical estimation and immunohistochemistry.

Hesperidin Produces Cardioprotective Activity via PPAR-γ Pathway in Ischemic Heart Disease Model in Diabetic Rats

“…In the present study, while decreased levels of CK-MB and LDH, increased levels of MDA were encountered in the heart of diabetic rats subjected to cardiac I/R injury which denotes oxidative stress. These observations are in accordance with the previous literature where increased lipid peroxidation products and MDA and decreased CK-MB isoenzymes and LDH was observed in hearts exposed to oxidative stress [26]. Myocardial CK-MB isoenzyme and LDH activities were decreased in the diabetic rats [27].Serum LDH activity was found to elevate in the patients with type II diabetes [28].…”

Methanolic Extract of Ricinus Communis ameliorated cardiovascular dysfunction in dichlorvos-exposed rats

“…However, treatment with the methanolic extract of Ricinus communis significantly ameliorated the deviations in electrocardiac parameters compared to dichlorvos-induced rats. This reveals the cardioprotective effect of the extract, which aligns with the findings of Charan et al (2009).…”

Telmisartan, a dual ARB/partial PPAR-γ agonist, protects myocardium from ischaemic reperfusion injury in experimental diabetes

“…Lipid peroxide metabolism and cardiac injury marker enzymes (CK‐MB isoenzyme and LDH) play an important role in the pathogenesis of MI and are hallmarks of I/R injury. A significant increase in the level of lipid peroxidation products and MDA, and a decrease in the level of the CK‐MB isoenzyme and LDH in the heart clearly indicate an increase in oxidative stress [30]. In this study, an elevated level of MDA and decreased activities of the CK‐MB isoenzyme and LDH in the diabetic I/R group and the diabetic I/R group treated with GW9662 indicated the presence of tissue injury in comparison with the diabetic sham group.…”