Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy

Abstract

CeO2 nanoparticles protect against the progression of cardiac dysfunction and remodeling by attenuation of myocardial oxidative stress, ER stress, and inflammatory processes probably through their autoregenerative antioxidant properties.

Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death

“…50 Finally, nanoceria might also be cardioprotective as intravenous injection of nanoceria attenuated left ventricle dysfunction and dilation of the heart of monocyte chemo-attractant protein 1 transgenic mice. 51 This effect was accompanied by a decrease in nitrotyrosine protein modification, inflammatory cytokines and ER stress gene expression. 51 Although many studies, including the present one, have reported antioxidant and cytoprotective effects of nanoceria, a few studies have provided conflicting data.…”

“…51 This effect was accompanied by a decrease in nitrotyrosine protein modification, inflammatory cytokines and ER stress gene expression. 51 Although many studies, including the present one, have reported antioxidant and cytoprotective effects of nanoceria, a few studies have provided conflicting data. 37,[52][53][54] Differences in cell types, tissue context, environmental factors and nanoparticle synthesis and concentration might account for these conflicting findings.…”

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

“…ROS can be induced by several mechanisms, including (i) the interfernce with redox active proteins, (ii ) interaction with oxidative organelles such as the mitochondria, (iii) chemical reactions of the coating, reactive surface groups or ions leached from the NP surface in the acidic environment of endo-or lysosomes and (iv) by activation of several signalling pathways through interaction with cell surface receptors 28,40 . This paradigm does however not account for all NP: CeO2NP, for example, were found not to cause ROS induction but on the contrary even showed a protective effect against ROS damage in vivo as well as in vitro 51,52 . Furthermore, Gao et al…”

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

“…84 The potential pharmacological activity of CeONP has also been evaluated. It was shown that CeONP could prevent retinal degeneration induced by intracellular peroxides 96 and could relieve the symptoms of ischemic stroke, 91 ischemic cardiomyopathy, 113 diabetes, 93 radiation-induced pneumonitis 105 and lupus 84 in animal models of disease. These effects mainly depended on the ROS scavenging ability of CeONP.…”