Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model

Huang, Jing; Lei, Ying; Lei, Shengping; Gong, Xinwen

doi:10.1080/15376516.2021.1965274

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…Similar results were obtained by other cytotoxic drugs on the myocardium as cyclophosphamide (Refaie, El-Hussieny et al 2022) or doxorubicin (Pınarlı, Turan et al 2013, Huang, Lei et al, 2022 due to the toxic effects of these drugs in addition to the associated myocardial ischemia that leads to chromosomal aberrations, cardiac cell death, and apoptosis.…”

Section: Discussionsupporting

confidence: 72%

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Rateb

Gomaa²,

Hussein³

2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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Background: Cardiotoxicity is a common adverse reaction to cisplatin treatment. Not all the mechanisms underlying cisplatin-induced cardiotoxicity have been described. Stem cells have been acknowledged as a potentially effective, novel treatment approach in treating several diseases. Objective: The current study was done to assess the impact of adipose mesenchymal stem cells (ADMSCs) in repairing cardiac damage induced by cisplatin and to investigate the underlying mechanisms.Materials and Methods: 32 rats were utilized for this study. They were randomly classified into four equal groups: the Control group that received saline intraperitoneally (i.p.), the Cisplatin-treated group that received a single i.p. injection of cisplatin at a dose of 7 mg/kg and was left for 5 days, Stem celltreated group that administered cisplatin as before and after 5 days they received a single dose of ADMSCs (1 × 10 6 ) mL injected intravenously and were left for 60 days after cell injection, and the Withdrawal group that received cisplatin in same dose and manner of administration as above and then left for 65 days. At the end of the experiment, the portions of the heart specimen were used to determine the levels of Total antioxidant capacity (TAC), cardiac Malondialdehyde (MDA), Tumur nuclear factor-α (TNF-α), and interleukin 2 (IL-2). The remaining portions of the heart muscle were prepared for histological and immunohistochemistry studies. Results: Cisplatin treated group revealed extensively disrupted organization of muscle fibers that appeared remarkably damaged with focal lysis with the widening of the spaces among the myofibrils, severely distorted nuclei which appeared highly condensed and had irregular malformed shapes with severe mitochondrial changes. Also, the levels of proinflammatory cytokines e.g., TNF-α and IL-2 were increased in the cardiac tissue. Also, increased MDA and decreased TAC levels were detected. Injection of ADMSCs ameliorated cardiotoxicity induced by cisplatin via suppression of oxidative injury, inhibition of pro-inflammatory cytokines, suppression of apoptotic cascades, and activation of angiogenesis. Conclusion: This study could be considered preliminary in proving that AD-MSCs therapy has a promising role to enhance marked regeneration of cisplatin-induced myocardial injury.

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Section: Discussionsupporting

confidence: 72%

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Rateb

Gomaa²,

Hussein³

2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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“…[44,45] Our results found that DOX exposure caused the decrease of EF and SV in rats, which is in accordance with previous reports in mice, [46] whereas VitB 6 supplement could increase EF and SV. BNP is another indicator to evaluate cardiac function, which will be released into the blood in large quantities [47,48] when the heart was injured by DOX. In this study, the serum content of BNP was increased significantly in rats treated with DOX compared with that of the control group, which was consistent with the previous study.…”

Section: F I G U R E 4 (See Caption On Next Page)mentioning

confidence: 99%

Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Sun,

Wang,

Gui

et al. 2023

J Biochem & Molecular Tox

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Doxorubicin (DOX) has been used to treat various types of cancer, but its application is limited due to its heart toxicity as well as other drawbacks. Chronic inhibition of Na+/H+ exchanger (NHE1) reduces heart failure and reduces the production of reactive oxygen species (ROS); vitamin B6 (VitB6) has been demonstrated to have a crucial role in antioxidant mechanism. So, this study was designed to explore the effect of VitB6 supplement on the DOX‐induced cardiotoxicity and to imply whether NHE1 is involved. Ultrasonic cardiogram analysis revealed that VitB6 supplement could alleviate DOX‐induced cardiotoxicity; hematoxylin and eosin (HE) and Masson's staining further confirmed this effect. Furthermore, VitB6 supplement exhibited significant antioxidative stress and antiapoptosis effect, which was evidenced by decreased serum malondialdehyde (MDA) content and increased serum superoxide dismutase (SOD) content, and decreased Bcl‐2‐associated X protein/B‐cell lymphoma‐2 ratio, respectively. Collectively, VitB6 supplement may exert antioxidative and antiapoptosis effects to improve cardiac function by decreasing NHE1 expression and improve DOX‐induced cardiotoxicity.

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“…It was reported by Zhang et al (2022) that corilagin induced apoptosis and inhibited HMBG1/PI3K/AKT signaling pathways in gastric cancer in vivo[29] Huang et al (2022). reported that corilagin improved doxorubicin induced cardiac function by reducing injury, inflammation and promoting apoptosis in rats[30].Liu et al (2021) reported that corilagin reduced NRF2 expression and induced apoptosis and autophagy[4]. In the literature, there are…”

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confidence: 99%

Genotoxic And Antigenotoxic Effects Of Corilagin In In Vitro Human Lymphocyte Cultures

TURAN

Taner

2022

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Bitkiler tarafından ikincil metabolitler olarak sentezlenen doğal bileşiklerin, serbest radikallerin neden olduğu oksidatif strese ve bunların aracılık ettiği genetik hasara karşı koruyucu etkilerinin olduğu birçok araştırmada bildirilmiştir. Bu doğal bileşikler arasında polifenollerin özellikle güçlü antioksidan aktiviteleri olduğu bilinmektedir. Euphorbiaceae, Geraniaceae ve Lythracea familyaları gibi birçok bitki türünde bulunan bir tanen olan korilagin, çok çeşitli farmakolojik etkilere sahiptir. Bu çalışmada, korilaginin güvenli konsantrasyonlarını belirlemek için in vitro insan periferik kan lenfosit kültürlerinde mikroçekirdek (MÇ) ve kromozom anormallikleri (KA) testleri kullanılarak genotoksik/antigenotoksik etkileri araştırıldı. 10-100 µg/ml korilagin hücrelere tek başına ve 0.2 µg/ml MMC ile eş zamanlı olarak uygulandı ve tüm analizler 3 tekrarlı olarak gerçekleştirildi. Analizlerin sonuçlarına göre korilaginin 10, 25, 50 µg/ml uygulama konsantrasyonlarında MÇ ve KA oluşumunda istatistiksel olarak anlamlı bir artışa neden olmadığı hatta MMC uygulaması ile artan MÇ frekansında ve kromozom anormalliklerde istatistiksel olarak önemli oranda azalma sağladığı belirlenmiştir. Diğer yandan bu etkinin konsantrasyona bağlı olduğu ve 100 µg/ml’de DNA hasarını artıcı etki gösterdiği belirlenmiştir. Bu durumun birçok güçlü antioksidanda görülen konsantrasyona bağlı prooksidan aktivite nedeniyle olduğu düşünülmektedir. Çalışma sonuçları korilaginin düşük konsantrasyonlarının MMC gibi genotoksik ajanlar tarafından oluşan genetik hasara karşı antigenotoksik etkisinin olduğunu, kemoterapinin yan etkilerine karşı kullanılabileceğini göstermektedir.

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Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model

Cited by 9 publications

References 44 publications

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Genotoxic And Antigenotoxic Effects Of Corilagin In In Vitro Human Lymphocyte Cultures

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Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model

Cited by 9 publications

References 44 publications

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Adipose Tissue-Mesenchymal Stem Cells Improve Cisplatin-Induced Cardiotoxicity in Rats Via Modulating Apoptosis, Oxidative Stress, Inflammation, and Angiogenesis

Protective effect of vitamin B6 against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Genotoxic And Antigenotoxic Effects Of Corilagin In In Vitro Human Lymphocyte Cultures

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Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression