Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

Testai, Lara; Martelli, Alma; Cristofaro, M. De; Breschi, Maria Cristina; Calderone, Vincenzo

doi:10.1111/jphp.12032

Cited by 85 publications

(56 citation statements)

References 36 publications

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“…It has been reported that CH exerts benecial effects on the cardiovascular function, with antioxidant and anti-inammation activity. Previous work has proved that CH could reduce ischemia-reperfusion injury in a Langendorff-perfused rat heart model (Testai et al 2013). …”

Section: Discussionmentioning

confidence: 99%

Retracted Article: Chrysin attenuates myocardial ischemia–reperfusion injury by inhibiting myocardial inflammation

Nan

Yang

et al. 2018

RSC Adv.

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The aim of this study was to investigate the effects of chrysin (CH) on myocardial ischemia-reperfusion injury. Cytokines were reduced by CH in coronary artery occlusion-induced rats and also in H9C2 cells.The ST segment was also restored by CH. Triphenyltetrazolium chloride (TTC) staining and pathological analysis showed that CH could alleviate myocardial injury. Results in H9C2 cells showed that CH improved heart injury in hypoxia/reoxygenation (H/R) of H9C2 cells. In addition, the expressions of the HMGB1-related inflammation pathway in rats and H9C2 cells were significantly decreased by CH. The present study shows the protective effects of CH on myocardial injury via inflammation.

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Section: Discussionmentioning

confidence: 99%

Retracted Article: Chrysin attenuates myocardial ischemia–reperfusion injury by inhibiting myocardial inflammation

Nan

Yang

et al. 2018

RSC Adv.

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“…ISO is also identified to create oxidative stress or amplify oxidative hassle by means of configuration of adrenochromes through its auto-oxidation, which is concerned in the production of extremely toxic oxygen-derived free radicals and augments generation of thiobarbituric acid reactive substance as increase in lipid peroxidation [62,63]. In the present study, we observed that AP protected the myocardium from ISO-induced myocardial membranous injury via positively enhanced hemodynamic, electrocardiographic, biochemical and histopathological parameters, suggesting that its cardioprotective action has been reported to improve cardiac function and improve the action of PPARc receptor signalling [64][65][66].…”

Section: Discussionmentioning

confidence: 99%

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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Apigenin (AP) is a flavone in dietary flavonoids reported as strong antioxidant and elite modulator of PPARγ. The current study evaluated the consequence of AP in isoproterenol (ISO)-induced oxidative stress and myocardial infarction during β-adrenergic receptor stimulus in rats by persistent hemodynamic, biochemical and histopathological changes. Rats received AP (25, 50 and 75 mg/kg/day) or vehicle i.p. for 14 days and ISO (100 mg/kg, s.c.) on 13th and 14th days for initiation of cardiotoxicity. ISO-treated rats showed evidence of significant dwindle in systolic and diastolic arterial pressures, maximal positive rate of developed left ventricular pressure. In totting up, a noteworthy diminution in activities of creatine kinase-MB isoenzyme, reduced glutathione, superoxide dismutase, catalase and level along with rise in malondialdehyde content were observed. The shielding function of AP on isoproterenol-induced myocardial damage was observed by attenuating all the endogenous parameters and the membrane-bound enzymes. It was confirmed by histopathological examinations. The effect of AP at the doses of 50 and 75 mg/kg showed added apparent than at the dose of 25 mg/kg. Current study thus provides confirmation for protective effects of AP on myocardium in experimentally induced myocardial infarction.

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“…This channel is structurally similar to that expressed on the sarcolemma and is involved in vasodilatation that, at the mitochondrial level, plays a crucial role in I/R events. Indeed, naringenin promoted reduced mitochondrial calcium uptake and mild mitochondrial depolarization as well as restricting the probability of mitochondrial permeability transition pore (MPTP) formation and apoptotic death of myocardiocytes [66,67,68]. …”

Section: Putative Mechanisms Of Action Responsible For the Cardiovmentioning

confidence: 99%

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

2017

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Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value. Methods- In this review an examination of literature was performed while considering both epidemiological, clinical and pre-clinical evidence supporting the beneficial role of the flavanone class. We evaluated studies in which citrus fruit juices or single flavanone administration and cardiovascular risk factors were analysed; to identify these studies, an electronic search was conducted in PUBMED for papers fulfilling these criteria and written in English. Results- In addition to epidemiological evidence and clinical studies demonstrating that fruits in the Citrus genus significantly reduce the incidence of cardiovascular disease risk, pre-clinical investigations highlight cellular and subcellular targets that are responsible for these beneficial effects. There has been special attention on evaluating intracellular pathways involved in direct cardiovascular and cardiometabolic effects mediated by naringenin, hesperetin and eriodictyol or their glycosylated derivatives. Conclusions- Although some mechanisms of action remain unclear and bioavailability problems remain to be solved, the current evidence supports the use of a nutraceutical approach with citrus fruits to prevent and cure several aspects of cardiovascular disease.

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Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

Cited by 85 publications

References 36 publications

Retracted Article: Chrysin attenuates myocardial ischemia–reperfusion injury by inhibiting myocardial inflammation

Retracted Article: Chrysin attenuates myocardial ischemia–reperfusion injury by inhibiting myocardial inflammation

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

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