Cardioprotective Effects of Honey and Its Constituent: An Evidence-Based Review of Laboratory Studies and Clinical Trials

Idrus, Ruszymah Bt Hj; Sainik, Nur Qisya Afifah Veronica; Nordin, Abid; Saim, Aminuddin Bin; Sulaiman, Nadiah

doi:10.3390/ijerph17103613

Cited by 39 publications

(18 citation statements)

References 41 publications

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“…Traditionally, honey was widely used for wound healing, as a food preservative, and against gastrointestinal illnesses [ 12 ]. According to recent literature, honey has revealed the presence of several beneficial effects for human health such as antibacterial [ 13 ], antioxidant, anti-inflammatory [ 14 ], and cardioprotective effects [ 15 ], with potentials as antiobesity [ 16 ] and neuroactivation associated with spatial memory [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats

Lafraxo

Bakour

Laaroussi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Diabetes is a metabolic disorder characterized by a chronic increase in blood glucose. Owing to the limitations observed with antidiabetics in modern medicine, medicinal plants and bee products are known as good matrices for the search for new antidiabetic molecules. The present study focused on the evaluation of the hypoglycemic and the protective properties of two natural products widely used in complementary and alternative medicine (thyme honey and olive oil). To achieve this, the study was carried out on Wistar rats rendered diabetic by the injection of a single dose of alloxan monohydrate (65 mg/kg body weight (BW)). First, the physicochemical characterization and the phytochemical analysis of thyme honey and olive oil were carried out, and then in vivo study was conducted on 42 Wistar rats divided into seven groups: three groups were normal, one group was untreated diabetic, and three groups were diabetic rats treated with thyme honey (2 g/kg BW) or olive oil (10 mL/kg BW) or their combination ((1 g/kg BW of thyme honey) and (5 mL/kg BW of olive oil)). During the experiment, the glycemia was measured regularly every 10 days. After 30 days of treatment, the rats were sacrificed. The serum and urine were analyzed to determine hepatic enzymes levels (AST, ALT, ALP, and LDH), lipidic profile (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein), and kidney parameters (urea, uric acid, creatinine, total protein, sodium, potassium, and chloride). The liver, pancreas, and kidneys were analyzed to evaluate their histological changes and to determine their enzymatic antioxidant content (catalase, GSH, and GPx) and the levels of MDA. The results obtained showed that thyme honey or olive oil, and especially their combination, improved significantly the blood glucose levels and they protect against metabolic changes and the complications induced by diabetes.

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Section: Introductionmentioning

confidence: 99%

The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats

Lafraxo

Bakour

Laaroussi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Research has revealed that honey has a protective effect for the cardiovascular system by preventing the oxidative stress process of blood vessels, improving the plasma lipid constituents and attenuating elevation of heart function marker [209][210][211].…”

Section: Other Honeys Properties Valuable For Apitherapymentioning

confidence: 99%

Towards a Better Understanding of Nutritional and Therapeutic Effects of Honey and Their Applications in Apitherapy

et al. 2021

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The nutritional and therapeutic aspects of natural products have gained more interest in recent years, owing to the importance that has been given to health and well-being. In this regard, honey represents an organic product whose high level of biologically active compounds and valuable nutrients have been extensively studied in order to prove its ability to provide an enhancement in health status. The use of honey in the process of healing or preventing certain diseases has been practiced throughout history and is now known as apitherapy. The aim of this review is to expand the knowledge and understanding towards the physicochemical characteristics of honey and the action of its main bioactive compounds towards health-beneficial properties (antioxidant, antimicrobial, antifungal, antiviral, etc.) for apitherapeutic purposes. Notwithstanding all the assets, the usage of honey for medical purposes encounters some limi-tations regarding the factors that may affect the therapeutic potential of honey in apitherapy that will be pointed out in this overview.

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“…Cardiovascular Diseases (CVDs) are the main cause of morbidity and mortality, accounting for 31% of all global deaths. Lipid abnormalities are the most important contributors to CVDs that include increased concentrations of Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C), and Triglycerides (TG) as well as decreased concentrations of High Density Lipoprotein Cholesterol (HDL-C) and its combinations (1) . Diet modification remains the main strategy for CVD management and lipid profile control.…”

Section: Introductionmentioning

confidence: 99%

“…CVD are the main cause of morbidity and mortality, accounting for 31 % of all global deaths. Lipid abnormalities are the most important contributors to CVD that include increased concentrations of total cholesterol (TC), LDL-cholesterol and TAG as well as decreased concentrations of HDL-cholesterol and its combinations (1) .…”

mentioning

confidence: 99%

The effect of honey on lipid profiles: a systematic review and meta-analysis of controlled clinical trials

et al. 2021

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Honey is known not only as a natural food but also as complementary medicine. According to the controversial evidence about the effects of honey on blood lipids, this meta-analysis was performed to investigate the potential effects of honey on lipid profiles. Relevant studies were identified by searching PubMed, Web of Science (WOS), Scopus, EMBASE, and Cochrane databases. All human controlled clinical trials (either with a parallel or a crossover design) published in English that reported changes in serum lipid markers (Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-C), High Density Lipoprotein Cholesterol (HDL-C), and LDL-C/HDL-C ratio) following honey consumption were considered. Standardized Mean Differences (SMDs) and their respective 95% Confidence Intervals (CIs) were calculated to assess the changes in lipid profiles following honey consumption by random effects model. Statistical heterogeneity, sensitivity analysis, publication bias, and quality of the included studies were assessed, as well. The meta-analysis of 23 trials showed that honey had no significant effects on TC, TG, LDL-C, HDL-C, and LDL-C/HDL-C ratio. Significant heterogeneity was seen among the studies for all the studied factors (I2 index > 50%). Subgroup analysis based on the lipid profile status, types of honey, and intervention duration revealed no significant effect on TC, TG, LDL-C, and HDL-C. Quality of the evidences varied form very low to moderate according to various parameters. In conclusion, honey consumption did not affect serum lipid profiles (TC, TG, LDL-C, HDL-C, and LDL-C/HDL-C ratio).

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Cardioprotective Effects of Honey and Its Constituent: An Evidence-Based Review of Laboratory Studies and Clinical Trials

Cited by 39 publications

References 41 publications

The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats

The Synergistic Beneficial Effect of Thyme Honey and Olive Oil against Diabetes and Its Complications Induced by Alloxan in Wistar Rats

Towards a Better Understanding of Nutritional and Therapeutic Effects of Honey and Their Applications in Apitherapy

The effect of honey on lipid profiles: a systematic review and meta-analysis of controlled clinical trials

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