Cardioprotective Effects of Oral Nicorandil Use in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention

Abstract

In diabetic patients undergoing elective PCI, nicorandil intake was associated with decreased incidence of PCI-related myocardial injury and improvement of LVEF% after 6 months.

The clinical effect of nicorandil on perioperative myocardial protection in patients undergoing elective PCI: A Systematic Review and Meta-Analysis

“…The hidden distribution of the sixteen articles26272829303132333435363738394041 is low; Fifteen articles262728293031323334353637383941 used a random single blind method, but the blind method of one article40 is not clear. The incomplete outcome data, selective reporting of results and other biases of the sixteen articles26272829303132333435363738394041 are low. The literature quality score is shown in Table 2.…”

“…Then, the full texts of 43 articles were downloaded to evaluate in detail. Eventually, data from 16 articles26272829303132333435363738394041 include 1616 patients were listed into this meta-analysis. Among these patients, 804 patients in the nicorandil group and 812 patients in the control group.…”

“…Of the 16 articles, four articles31323339 used a random number method, three articles283041 used a block randomization, eight articles2627293435363738 refer to the random method, but did not give a specific description, and the random method of the rest article40 is not clear. The hidden distribution of the sixteen articles26272829303132333435363738394041 is low; Fifteen articles262728293031323334353637383941 used a random single blind method, but the blind method of one article40 is not clear.…”

“…However, the conclusion, whether nicorandil has a myocardial protective effect is inconsistent. Hwang J26 and Kim J27 have found that nicorandil had no significant effect on PMI and cardiac enzymes after PCI in patients with stable or unstable angina, but Kim S28, Murakami M29 and Shehata M30 have carried out studies about the clinical effect of nicorandi, and their conclusion is that nicorandil can significantly reduce myocardial enzymes in patients after PCI, which was different from Hwang J and Kim J. Therefore, the purpose of our meta-analysis is to evaluate the myocardial protective effect of nicorandil in the perioperative period of patients after PCI, and to provide a reference for clinical applications.…”

Myocardial Preconditioning by Intracoronary Adenosine before Elective Percutaneous Coronary Intervention (short term outcome)

“…T heir conclusion that in diabetic patients undergoing elective PCI, intracoronary adenosine was associated with decreased incidence of PCIrelated myocardial injury and improvement of left ventricular EF % after 3 months despite there was no statistically significant difference between both groups regarding incidence of major adverse cardiac events (MACE). 27 Against our study , Chi-hang Lee et al In their study of 62 patients undergoing elective coronary angioplasty showed that pretreatment with intracoronary adenosine prevents the risk of periprocedural myocardial infarction. 28 In our current study the expected occurrence of periprocedural myonecrosis was absent, this may be potentially resulted from the low risk profile of our patients being not in acute coronary syndrome (ACS) sitting, our patients were patients with single vessel disease and not for complex PCI (e.g.…”