2014
DOI: 10.1016/j.ejphar.2014.10.001
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Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats

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Cited by 40 publications
(31 citation statements)
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“…Matrine, oxymatrine, and sophocarpine are typical matrine‐type alkaloids extracted from S. flavescens exhibiting similar bioactive effects attributed to their comparable molecular structures. Matrine, oxymatrine, and sophocarpine were known as cardiovascular protective agents and showed potent antioxidant effects 20, 26, 34…”
Section: Discussionmentioning
confidence: 99%
“…Matrine, oxymatrine, and sophocarpine are typical matrine‐type alkaloids extracted from S. flavescens exhibiting similar bioactive effects attributed to their comparable molecular structures. Matrine, oxymatrine, and sophocarpine were known as cardiovascular protective agents and showed potent antioxidant effects 20, 26, 34…”
Section: Discussionmentioning
confidence: 99%
“…25 Moreover, rodents submitted to isoproterenol subcutaneous injections show progressive LV remodeling, with impairment of both systolic and diastolic LV functions. 24,26 We, therefore, tested the effects of aldosterone and Gal-3 antagonism in an HF model associated with diffuse myocardial damage and cardiac hyperaldosteronism, in the absence of discrete myocardial infarction or afterload increase, as for the case of coronary artery ligation and transverse aortic constriction, respectively, 25 thus resembling clinical nonischemic dilated cardiomyopathy.…”
Section: Discussionmentioning
confidence: 99%
“…CHF involves ventricular remodeling and hypertrophy, reduced cardiac ejection fractions (EFs) and impairment of active relaxation and contraction of the left ventricle [3]. CHF represents a major public health problem in the world because of its high morbidity, mortality and cost [4].…”
Section: Introductionmentioning
confidence: 99%