2014
DOI: 10.1016/j.mce.2014.04.010
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Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction

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Cited by 50 publications
(30 citation statements)
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“…Thus, a 10week aerobic training did not promote an increase in FAC above normal. In AMI animals (S-AMI and T-AMI), we found significant reductions in all echocardiographic D r a f t parameters as demonstrated before (de Castro et al 2014). In our study, it seems that preventive aerobic training prevented major losses only in FAC to a significant degree.…”
Section: Discussionsupporting
confidence: 80%
“…Thus, a 10week aerobic training did not promote an increase in FAC above normal. In AMI animals (S-AMI and T-AMI), we found significant reductions in all echocardiographic D r a f t parameters as demonstrated before (de Castro et al 2014). In our study, it seems that preventive aerobic training prevented major losses only in FAC to a significant degree.…”
Section: Discussionsupporting
confidence: 80%
“…In view of this, the decrease in ROS levels caused by T3 and T4 administration does not seem to involve a modulation of the TRX or GRX systems. In previous work from our group, it was demonstrated that T3 and T4 administration was capable of decreasing xanthine oxidase expression [17], which is an important source of ROS. This mechanism could be a possible explanation for the lower levels of ROS found in AMIT rats.…”
Section: Discussionmentioning
confidence: 92%
“…In an experimental model of infarction, thyroid hormone administration was capable of promoting favourable ventricle remodelling and decreasing cardiac wall stress [15]. Recently, the effects of T3 and T4 after myocardial infarction were associated with an improvement in the redox status of the myocardium [17].…”
Section: Introductionmentioning
confidence: 99%
“…[20][21][22] TH therapy appears to protect against lipid peroxidation. 23 and enhance mitochondrial aerobic capacity. 24 Thus, indirectly improve oxidative stress level in uremic rats.…”
Section: Discussionmentioning
confidence: 98%