Cardioprotective Potential of Methanol Extract of &lt;em&gt;Polygonum glabrum&lt;/em&gt; on Isoproterenol Induced Myocardial Necrosis in Rats

Raja, S; Ramya, I

doi:10.5138/09750185.2125

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…), reduced the serum levels of ALT, an indication of hepatoprotective effect. AST is a mitochondrial enzyme secreted from the liver, heart, kidney, and skeletal muscle 24 . Liver toxicity raised the levels of AST in serum because of the injury to the tissues causing acute necrosis, like chronic acute cholestasis & viral hepatitis 20 .…”

Section: Discussionmentioning

confidence: 99%

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Vakkalagadda¹,

Ravula²,

Parameshwar³

et al. 2021

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The methanolic extract of leaves of C.dicoccum was evaluated for its hepatoprotective activity against paracetamol induced hepatotoxicity since it is reported to cause oxidative stress in the animal thereby altering the enzymatic levels. Fresh leaves were collected, shade dried and extract was prepared by cold maceration followed by drying in a rota-vapour using methanol to obtain MECD as a sticky semi-solid mass. Thirty rats were taken and divided into 5 equal groups where, Group I, II, and III served as Normal Control, Negative control (PCM 3g/kg), and Positive control (Silymarin 200mg/kg) respectively; whereas, Group IV and V served as test groups where the rats were pre-treated orally with MECD 200mg/kg and 400mg/kg respectively for six days before administering PCM. On the 8 th day all groups except Group I was administered with PCM (3g/kg). 48 hours post PCM induction, the animals were anesthetized, blood samples were obtained via retro-orbital sinus plexus and then the rats were sacrificed. The serum was assessed for the evaluation parameters like AST, ALT, ALP, and bilirubin levels. Apart from these; SOD, CAT, and MDA levels were also evaluated and it was concluded that treatment with MECD restored the levels to normal thereby exhibiting hepatoprotective activity. Moreover, histopathological evaluation was carried out to assess the liver for inflammation, infiltration, or necrosis where the MECD treated rats showed promising results.

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Section: Discussionmentioning

confidence: 99%

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Vakkalagadda¹,

Ravula²,

Parameshwar³

et al. 2021

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Plants and Phytochemicals for Prevention and Treatment of Myocardial Ischemia

Zanan,

Ansari,

Pullaiah

2024

Cardioprotective Plants

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Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Cheng¹,

Zhang²,

Jia³

et al. 2022

JIR

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Background Myocardial ischemic/reperfusion (I/R) injury is a key prognostic factor after the myocardial infarction. However, at the time of reperfusion, the myocardial tissue has undergone for the necrosis and initiated the induction of oxidative stress and inflammation. The current study was to scrutinize the cardioprotective effect of gossypin against ISO-induced I/R injury in myocardial tissue and explore the possible underlying mechanism. Methods Sprague Dawley (SD) was used in the current protocol and ISO was used for induction the I/R in rat. The rats were divided into different groups and received the oral administration of gossypin treatment before the reperfusion. The body weight, heart weight and heart body weight ratio were estimated. The antioxidant, cardiac injury parameters, inflammatory cytokines, inflammatory mediators, gut microbiota and lipid parameters were estimated. At the end, heart tissue histopathological study was carried out. Results ISO-induced I/R rats received the gossypin treatment significantly (P < 0.001) enhanced the body weight and decreased the heart weight, along with suppressed the infarct size. Gossypin treatment significantly (P < 0.001) reduced the level of heart parameters, such as creatinine kinase-MB (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK), cardiac troponin I (CTn-I) and cardiac troponin T (CTn-T) in the serum. Gossypin treatment significantly (P < 0.001) altered the cardiac function, hepatic, antioxidant, inflammatory cytokines and inflammatory mediators. Gossypin significantly (P < 0.001) suppressed the MMP-2 and MMP-9 in ISO-induced I/R rats. Gossypin treatment considerably alleviated the gut dysbiosis through altered Firmicutes to Bacteroidetes (F/B) ratio and also maintained the relative abundance of Butyricicoccus, Clostridium IV, Akkermansia, Roseburia and Clostridium XIVs. Conclusion Based on result, we can conclude that gossypin is an alternative drug for the treatment of ISO-induced I/R in rats via alteration of oxidative stress, inflammatory reaction and gut microbiota.

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Cardioprotective Potential of Methanol Extract of <em>Polygonum glabrum</em> on Isoproterenol Induced Myocardial Necrosis in Rats

Cited by 3 publications

References 23 publications

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Protective Potential of Canthium dicoccum Methanolic Extract Against Hepatic Injury in Rats

Plants and Phytochemicals for Prevention and Treatment of Myocardial Ischemia

Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

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