Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits

Abstract

The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plants T. arjuna (T.A.), P. nigrum (P.N), C. grandiflorus (C), and C. oxyacantha (Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats

“…In our study, significantly reduced activities of SOD and GPx and GRx and GST were observed in the heart tissues of ISO-treated rats compared with the activities observed in control rats. The observed decreases in the activities of these enzymes are in accord with findings reported in previous studies [ 12 , 53 ]; such decreases may be due to the increased utilization of these enzymes for scavenging ROS and their inactivation by excessive ISO oxidants [ 52 ]. Pretreatment with MP, however, improved the activities of cellular antiperoxidative enzymes.…”

Optimization of Cardioprotective Potential of Various Concentrations of Medicinal Plants by Using Response Surface Methodology

“…The cardioprotective potential of T. arjuna is attributed to the presence of potent antioxidant compounds (Aslam et al, 2015). The C. oxyacantha is deemed as best known cardiotonic hence it helps to improve the blood supply to heart by dilating blood vessels and attenuating symptoms of heart failure (Zafar et al, 2015). Serpentine present in R. serpentina is useful to cure hypertension and CVD.…”

“…Not to speak of underdeveloped or developed countries, the developed nations have also not been able to control and provide the successful solution for the management and treatment of cardiovascular disorders (Aslam et al, 2015). Cardiovascular diseases cause 17.1 million fatalities each year and it will reach upto 20 million in 2020 (Zafar et al, 2015). Among CVD, the Myocardial Infarction (MI) is the most dreaded menace.…”

Evaluation of the inflammatory predictive efficiency of progranulin as compared with common pro-inflammatory regulators

“…Myocardial infarction was induced with salbutamol at a dose level of 7.5 mg/Kg bw that was administered intraperitoneally once a day for 2 consecutive days, following which blood samples were taken to check levels of cardiac function biomarkers [22].…”