Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

Bhattacharjee, Swarnali; Elancheran, R.; Dutta, Kasturi; Deb, Prashanta Kumar; Devi, Rajlakshmi

doi:10.3389/fphar.2022.1009023

Cited by 9 publications

(1 citation statement)

References 84 publications

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“…This allows damaged cells to repair and renew. 53 , 54 Multiple in vitro and animal investigations demonstrated the antioxidant properties of A. calamus or α-asarone. It has been established that the plant’s bioactive compounds can scavenge free radicals by modulating the activity of particular endogenous enzymes and non-enzymatic components.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effects of α-Asarone Against Hexavalent Chromium-Induced Oxidative Damage in Mice

Alwaili,

Elhoby,

El-Sayed

et al. 2024

DDDT

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Introduction This comprehensive study investigated the therapeutic potential of α-asarone in mitigating myocardial oxidative damage, primarily induced by hexavalent chromium (Cr(VI)) exposure in mice. Methods In this experiment, 24 mice were divided into four groups to assess the cardioprotective role of α-asarone. The study focused on two treatment groups, receiving 25 mg and 50 mg of α-asarone, respectively. These groups were compared against a control group subjected to Cr(VI) without α-asarone treatment, and a normal control negative group. The key biochemical parameters evaluated included serum levels of Creatine Kinase-MB (CK-MB) and Troponin I, markers indicative of myocardial damage. Additionally, the levels of Malondialdehyde (MDA) were measured to assess lipid peroxidation, alongside the evaluation of key inflammatory biomarkers in cardiac tissue homogenates, such as Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β). Results Remarkably, α-asarone treatment resulted in a significant reduction in these markers compared to the control group. The treatment also elevated the activity of cardinal antioxidant enzymes like catalase (CAT) and superoxide dismutase (SOD), and reduced the glutathione (GSH). Furthermore, a notable upregulation of Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) in cardiac tissue homogenates was observed, highlighting a potential pathway through which α-asarone exerts its protective effects. Histopathological analysis of cardiac tissues revealed that α-asarone ameliorated the structural lesions induced by Cr(VI). The study thus provides substantial evidence that α-asarone ameliorates Cr(VI)-induced cardiotoxicity through a multifaceted approach. It enhances cardiac enzyme function, modulates free radical generation, improves antioxidant status, and mitigates histopathological damage in cardiac tissues. Given these findings, α-asarone emerges as a promising agent against Cr(VI)-induced myocardial injury. Purpose This study paves the way for further research into the cardioprotective properties of α-asarone and its potential application in clinical settings by specifically exploring the protective efficacy of α-asarone against Cr(VI)-induced cardiotoxicity and delineating the underlying biochemical and molecular mechanisms involved.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effects of α-Asarone Against Hexavalent Chromium-Induced Oxidative Damage in Mice

Alwaili,

Elhoby,

El-Sayed

et al. 2024

DDDT

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Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats

Vincent,

Stanely,

Ponnian

2024

J Biochem & Molecular Tox

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Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p < 0.05) increased and heart superoxide dismutase and catalase activities were significantly (p < 0.05) reduced in isoproterenol‐induced myocardial infarcted rats. Isoproterenol induction significantly (p < 0.05) elevated the plasma homocysteine and serum high sensitivity‐C‐reactive protein levels. Furthermore, an enzyme‐linked immunosorbent assay, reverse transcription polymerase chain study, and immunohistochemical (IHC) staining revealed significantly (p < 0.05) elevated levels and expression of serum/myocardial nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6 and significantly (p < 0.05) reduced levels/expression of serum/myocardial interleukin‐10 in myocardial infarcted rats. Nevertheless, isoproterenol‐induced rats treated with 3, 4‐dihydroxybenzoic acid considerably (p < 0.05) attenuated all the biochemical, molecular, and IHC parameters investigated and inhibited oxidative stress and inflammation and protected the heart, through its antioxidant and anti‐inflammatory mechanisms.

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Anti‐inflammatory, Antioxidant, and Antibacterial Activities with Molecular Docking Studies of Vitex Trifolia L. Targeting Human COX‐2 and Peroxiredoxin‐5

Fawwaz,

Purwono,

Sidiq

et al. 2024

ChemistrySelect

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Vitex trifolia L. is widely used as a traditional medicine owing to its secondary metabolites. This study aimed to determine the phytochemical profiling of the ethanolic extract of V. trifolia leaves (EEVL). Additionally, biological activities were investigated, supported by molecular docking studies. The total flavonoid and phenolic contents of the EEVL were 35.25 ± 0.13 mg QE/g extract and 39.55 ± 1.43 mg GAE/g extract, respectively. The EEVL exhibits anti‐inflammatory activity with a half‐maximal inhibitory concentration (IC50) value of 153.59 µg/mL. The antioxidant activity of the EEVL exhibited an IC50 value of 20.41 ± 0.08 µg/mL with the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging method, a half‐maximal effective concentration value of 80.85 ± 0.39 µg/mL with the cupric‐reducing antioxidant capacity (CUPRAC) method, and a capacity of 180.58 mg QE/g extract with the ferric‐reducing antioxidant power (FRAP) method. At 16% concentration, the EEVL exhibited an antibacterial activity against some pathogenic bacteria. Molecular docking studies reported that casticin interacts with sodium diclofenac similarly toward 1PXX. However, artemitin exhibited better affinity toward 1HD2 than ascorbic acid. Thus, the EEVL has significant potential as a natural source for treating various diseases related to inflammation, oxidation, and infection. Moreover, screening of its active compounds is necessary for further exploration.

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Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

Cited by 9 publications

References 84 publications

Cardioprotective Effects of α-Asarone Against Hexavalent Chromium-Induced Oxidative Damage in Mice

Cardioprotective Effects of α-Asarone Against Hexavalent Chromium-Induced Oxidative Damage in Mice

Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats

Anti‐inflammatory, Antioxidant, and Antibacterial Activities with Molecular Docking Studies of Vitex Trifolia L. Targeting Human COX‐2 and Peroxiredoxin‐5

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