Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat

Dieleman, Jan M.; Lange, Fellery de; Houston, R.; Biessels, Geert Jan; Bär, P.R.; Mackensen, G. Burkhard; Grocott, Hilary P.; Kalkman, Cor J.

doi:10.1016/j.lfs.2006.01.036

Cited by 14 publications

(14 citation statements)

References 22 publications

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“…The visible platform task results further indicated that there were no differences in motivation, motor function, or visual function. While some authors showed deficits in MWM latencies after CPB on POD 3-12 (Mackensen et al, 2001), the results of the current study that focused on POD 7-12 suggest that these deficits might be transient, as proposed by others (Dieleman et al, 2006).…”

Section: Discussionsupporting

confidence: 54%

“…deficits (Dieleman et al, 2006). The motor deficits in our study affected the CPB group but not the DHCA group.…”

Section: Discussioncontrasting

confidence: 48%

“…Cognitive dysfunction has been shown in rats after normothermic CPB on post-operative days (POD) 3 to 12 (Ma et al, 2003;Mackensen et al, 2001) but not at 4 to 12 weeks (Dieleman et al, 2006). A recently developed rat model of DHCA has shown significant duration-dependent neurologic impairment and organ dysfunction, in which even shorter periods of DHCA, usually clinically tolerated (b40 min), had clinical consequences .…”

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confidence: 99%

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Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits

et al. 2007

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Section: Discussionsupporting

confidence: 54%

“…deficits (Dieleman et al, 2006). The motor deficits in our study affected the CPB group but not the DHCA group.…”

Section: Discussioncontrasting

confidence: 48%

mentioning

confidence: 99%

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Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits

et al. 2007

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“…These domains may include verbal and language skills, memory and learning, attention, concentration and perception, visual and spatial skills, visual motor and manual skills, numerical skills, executive functions, and composite measures [3]. There are even neuropsychological tests for laboratory animals; for example, tests measuring the time a thirsty rat needs to track down drinking water [4]. These tests are used in experimental settings to study disturbances in learning and memory functions, attributed to, for example, the use of anesthetics.…”

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confidence: 99%

Postoperative cognitive decline

2009

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Memory loss and lack of concentration are symptoms that frequently occur in patients who have undergone a surgical procedure. Although cognitive function can be assessed using neuropsychological tests, reliable diagnosis of postoperative cognitive decline (POCD) appears to be difficult. Therefore, the true incidence of POCD is unknown. Severe POCD, which is apparent even without neuropsychological testing, is reported most frequently after cardiac and hip-replacement surgery. In these cases, POCD probably reflects microembolic brain injury. Apart from the nature of the surgical procedure, advanced age is the most important risk factor for POCD. The anesthetic technique is not a determinant of POCD: the risk of POCD appears to be similar after both general and regional anesthesia.

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“…Morris water maze testing of spatial learning capacity was conducted as described previously [17]. Briefly, the Morris water maze consisted of a large circular black pool (210 cm diameter, 50 cm height, filled to a depth of 30 cm with water at 28±1°C), which was placed in a darkened room, illuminated by dim red light.…”

Section: Methodsmentioning

confidence: 99%

Remote ischemic preconditioning protects neurocognitive function of rats following cerebral hypoperfusion

Gong

Zhu

et al. 2011

Med Sci Monit

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SummaryBackgroundProtection of remote ischemic preconditioning on neurocognitive function caused by bilateral common carotid artery occlusion has been investigated in rats.Material/MethodsThirty-six male Sprague-Dawley rats were divided into 3 groups – control group (Group C, n=12), bilateral carotid arteries occlusion group (Group B, n=12) and remote ischemic precondition group (Group P, n=12). In Group P, remote ischemic preconditioning (RIPC) was performed on the right femoral artery with 3 cycles (10 min) of occlusion/perfusion. After 3 cycles of preconditioning, bilateral carotid arteries were occluded immediately for 60 min. In Group B, ischemic insults were conducted without RIPC. Sham surgeries were performed in Group C. Evaluation of memory and learning capacity was performed on days 5–8 after surgery by Morris water maze testing of spatial learning capacity (n=6 for each group). Apoptosis of cells in the hippocampus region was determined by TUNEL tests and Bcl-2 at this region was determined by ELISA 24 h and 9 days after vessel occlusion (n=6 for each group).ResultsNeurocognitive tests showed that latency time was significantly longer in Group B than in Group P on day 7 (p=0.016) and day 8 (p=0.036). Moreover, frequency of platform crossings was significant less in group B than in the other 2 groups on day 9. Bcl-2 level was significantly increased in the hippocampal region of rats in Group P on days 1 and 9 after vessel occlusion. TUNEL test showed that apoptosis could be observed at 24 h after occlusion in Group B, but not in Group P and Group C. No apoptosis was observed on day 9.ConclusionsOur results suggest that RIPC can protect neurocognitive function of rats after bilateral carotid occlusions, and that Bcl-2 may play an important role in this protective effect.

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Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat

Cited by 14 publications

References 22 publications

Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits

Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits

Postoperative cognitive decline

Remote ischemic preconditioning protects neurocognitive function of rats following cerebral hypoperfusion

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