Cardiopulmonary exercise and 6-min walk tests as predictors of quality of life and long-term mortality among patients with heart failure due to Chagas disease

Ritt, Luiz Eduardo Fonteles; Carvalho, Antônio Carlos; Feitosa, Gílson Soares; Pinho-Filho, Joel Alves; Andrade, Marcus Vinicius Santos; Feitosa-Filho, Gilson Soares; Newby, L. Kristin; Lópes, Renato D.

doi:10.1016/j.ijcard.2013.06.064

Cited by 27 publications

(26 citation statements)

References 10 publications

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“…Dourado et al (20) showed that the 6MWT distance was associated with the MLwHFQ score (r = −0.4; p < 0.001) in 61 patients with Chagas dilated cardiomyopathy (aged 51 ± 14 years). Similar results were found by Ritt et al (21) who showed a signifi cant negative correlation (r = −0.375; p = 0.007) between better quality of life and higher 6MWT distance in a study involving 55 Chagas dilated cardiomyopathy patients with heart failure. The association between a submaximal functional capacity and quality of life found in these studies suggests that the evaluation of a patient's HRQoL is a useful tool for to detect any disabilities in the daily activities of ChD patients.…”

Section: Health-related Quality Of Life and Functional Capacity In Pasupporting

confidence: 86%

Health-related quality of life in patients with Chagas disease: a review of the evidence

Sousa

Costa

Souza

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Chagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi), remains a serious p ublic health issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical management are limited. Regionally, the disease is the major cause of disability secondary to tropical diseases in young adults. Health-related quality of life (HRQoL) impairment is common in patients with ChD, especially in those with Chagas dilated cardiomyopathy, the most severe manifestation of the disease, which frequently leads to heart failure. The aim of this review was to conduct a literature search for studies that have evaluated the determining factors of HRQoL in ChD patients. We included cross-sectional, case-control, cohort, and experimental studies, as well as clinical trials that evaluated the HRQoL in ChD patients aged 18 to 60 years and are presenting an explicit description of statistical analysis. Using a combination of keywords based on Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) for searches in PubMed and the Scientifi c Electronic Library Online (SciELO), 148 studies were found. After exclusions, 12 studies were selected for analysis. Three main fi ndings were extracted from these studies: 1) cardiac involvement is associated with a worse HRQoL in ChD patients; 2) HRQoL is associated with the patients' functional capacity; and 3) simple and inexpensive therapeutic measures are effective for improving HRQoL in ChD patients. Hence, ChD patients' functional capacity, the effectiveness of non-surgical conservative treatment, and cardiac involvement are important determining factors for the HRQoL in ChD patients.

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Section: Health-related Quality Of Life and Functional Capacity In Pasupporting

confidence: 86%

Health-related quality of life in patients with Chagas disease: a review of the evidence

Sousa

Costa

Souza

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Recently, a previous study reported that the VE/VCO 2 slope was the only variable assessed by CPET considered an independent predictor of survival in CHD patients [9]. The present study found no correlation between this variable and the 6MWT distance but, unlike the VO 2peak , the VE/VCO 2 slope is more related to the central function than to patient effort [10], which possibly explains the lack of correlation between these variables.…”

contrasting

confidence: 68%

Functional capacity and risk stratification by the Six-minute Walk Test in Chagas heart disease: Comparison with Cardiopulmonary Exercise Testing

Costa

Lima

Sousa

et al. 2014

International Journal of Cardiology

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“…Other authors, 30-32 assessing the prognostic value of VE/VCO 2 slope in CHF, have shown it to be a variable with excellent independent value, even higher than that of peak VO 2 , and important to patients who reach only submaximal exertion. In a population with CHF due to Chagas disease, Ritt et al 33 have reported that the best cutoff point for worse prognosis was VE/VCO 2 slope > 32.5, thus earlier than those reported by studies on other etiologies. Arena et al34 have published the following ventilatory classes based on VE/VCO 2 slope values: class I, VE/VCO 2 ≤ 29.9; class II, 30-35.9; class III, 36-44.9; class IV, ≥ 45.…”

Section: Major Variables and Their Meaningsmentioning

confidence: 82%

Cardiopulmonary Exercise Test: Fundamentals, Applicability and Interpretation

Herdy¹,

Ritt²,

Stein³

et al. 2016

Arquivos Brasileiros De Cardiologia

126

122

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Cardiopulmonary exercise test (CPET) has been gaining importance as a method of functional assessment in Brazil and worldwide. In its most frequent applications, CPET consists in applying a gradually increasing intensity exercise until exhaustion or until the appearance of limiting symptoms and/or signs. The following parameters are measured: ventilation; oxygen consumption (VO2); carbon dioxide production (VCO2); and the other variables of conventional exercise testing. In addition, in specific situations, pulse oximetry and flow-volume loops during and after exertion are measured. The CPET provides joint data analysis that allows complete assessment of the cardiovascular, respiratory, muscular and metabolic systems during exertion, being considered gold standard for cardiorespiratory functional assessment.1-6The CPET allows defining mechanisms related to low functional capacity that can cause symptoms, such as dyspnea, and correlate them with changes in the cardiovascular, pulmonary and skeletal muscle systems. Furthermore, it can be used to provide the prognostic assessment of patients with heart or lung diseases, and in the preoperative period, in addition to aiding in a more careful exercise prescription to healthy subjects, athletes and patients with heart or lung diseases.Similarly to CPET clinical use, its research also increases, with the publication of several scientific contributions from Brazilian researchers in high-impact journals.Therefore, this study aimed at providing a comprehensive review on the applicability of CPET to different clinical situations, in addition to serving as a practical guide for the interpretation of that test.

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Cardiopulmonary exercise and 6-min walk tests as predictors of quality of life and long-term mortality among patients with heart failure due to Chagas disease

Cited by 27 publications

References 10 publications

Health-related quality of life in patients with Chagas disease: a review of the evidence

Health-related quality of life in patients with Chagas disease: a review of the evidence

Functional capacity and risk stratification by the Six-minute Walk Test in Chagas heart disease: Comparison with Cardiopulmonary Exercise Testing

Cardiopulmonary Exercise Test: Fundamentals, Applicability and Interpretation

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