2015
DOI: 10.1590/1678-4162-7421
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Cardiopulmonary parameters in propofol- or thiopental-anesthetized dogs induced to pulmonary hypertension by serotonin

Abstract: Cardiopulmonary parameters in propofol-or thiopental-anesthetized dogs induced to pulmonary hypertension by serotonin ABSTRACTThe cardiopulmonary changes in propofol-or thiopental-anesthetized dogs induced to pulmonary hypertension (PH) were evaluated. Twenty adult animals were randomly assigned to two groups: propofol group (PG) and thiopental group (TG). In PG, propofol was used for induction (80.03mg.kg -1 ) and anesthesia maintenance (0.8mg.kg -1 .minute -1 ), while, in TG, thiopental was used (22±2.92mg.… Show more

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“…Serotonin signaling has been suggested as being involved with the pathogenesis of DMVD in dogs (40)(41)(42)(43)(44) and humans (45,46) but very little is known about its effects on the pathogenesis of PH in dogs with DMVD. Serotonin can be used to induce PH in a canine animal model, suggesting involvement of 5HT in the pathogenesis of PH in dogs (47)(48)(49)(50)(51)(52). However, there is no study of naturally occurring PH in dogs with DMVD.…”
Section: Discussionmentioning
confidence: 99%
“…Serotonin signaling has been suggested as being involved with the pathogenesis of DMVD in dogs (40)(41)(42)(43)(44) and humans (45,46) but very little is known about its effects on the pathogenesis of PH in dogs with DMVD. Serotonin can be used to induce PH in a canine animal model, suggesting involvement of 5HT in the pathogenesis of PH in dogs (47)(48)(49)(50)(51)(52). However, there is no study of naturally occurring PH in dogs with DMVD.…”
Section: Discussionmentioning
confidence: 99%