Cardiopulmonary response to acute altitude exposure: Water loading and denitrogenation

Tucker, Adam; Reeves, John Τ.; Robertshaw, David; Grover, Robert F.

doi:10.1016/0034-5687(83)90079-8

Cited by 31 publications

(60 citation statements)

References 29 publications

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“…In humans [ 2 ] there is an antidiuresis with rapid decompression from 630 to 430 mmHg but not with equivalent normobaric hypoxia. Breathing 100 % oxygen before decompression results in no antidiuresis, suggesting an element of decompression stress.…”

Section: Hypobariamentioning

confidence: 96%

“…Total volume and solute output rise in parallel so urinary osmolality is not greatly altered [ 2 ]. These responses occur within the fi rst hour and persist for 1-2 days.…”

Section: Effects Of Hypoxia On Salt Water and Acid-base Balance Renmentioning

confidence: 98%

“…The loss is a result of decreased intake, but also of increased respiratory, cutaneous, and renal losses [ 2 ]. Upon return to normoxia or lower altitudes, the water loss is quickly corrected [ 48 ].…”

Section: Total Body Water and Volume Distributionmentioning

confidence: 99%

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Renal Function and Fluid Homeostasis

Swenson

Olsen

2013

High Altitude

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Hypoxia can directly affect the kidneys, but more importantly, its effects on systemic acid-base balance, ventilation, neuroendocrine refl exes, and hemodynamics all play a far greater part in altering renal function and fl uid balance. Acute and chronic effects of hypoxia and their magnitude may differ and these will be highlighted. These changes will be related to the common diseases of high altitude and to their impact on patients with chronic renal disease. Other features of high altitude separate from hypoxia, either alone or in combination, including hypobaria, exercise, and cold may also signifi cantly perturb renal function.

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Section: Hypobariamentioning

confidence: 96%

“…Total volume and solute output rise in parallel so urinary osmolality is not greatly altered [ 2 ]. These responses occur within the fi rst hour and persist for 1-2 days.…”

Section: Effects Of Hypoxia On Salt Water and Acid-base Balance Renmentioning

confidence: 98%

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Renal Function and Fluid Homeostasis

Swenson

Olsen

2013

High Altitude

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“…Scientists have debated this question for a long time, and the few studies that have been done present controversial results. Indeed, Tucker et al (1983) and Roach et al (1994Roach et al ( , 1995 showed that minute ventilation ( _ V V E ) was 30% greater in NH compared to HH without a significant change in arterial blood oxygen saturation (SaO 2 ), whereas Loeppky et al (1997) reported no difference in _ V V E with a higher SaO 2 after 30 or 60 min NH compared to HH. In animals, Levine et al (1988) found that arterial oxygen pressure (PaO 2 ) was higher in sheep in NH than in HH, whereas Shams et al (1990) did not, in a study of ducks.…”

Section: Introductionmentioning

confidence: 94%

Normo- and hypobaric hypoxia: are there any physiological differences?

et al. 2003

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Since Bert (1878) and Barcroft (1925), studies on hypoxia are realized by lowering ambient O(2) partial pressure (PO(2)) either by barometric pressure reduction (hypobaric hypoxia HH) or by lowering the O(2) fraction (normobaric hypoxia NH). Today, a question is still debated: "are there any physiological differences between HH and NH for the same ambient PO(2)?" Since published studies are scarce and controversial, we submitted 18 subjects in a random order to a 40-min HH test and to a 40-min NH test at an ambient PO(2) equal to 120 hPa (4500 m). Cardioventilatory variables [breathing frequency (f), tidal volume (V(t)), minute ventilation (V(E)), O(2) and CO(2) end-tidal fractions or pressures (FET(O2) and FET(CO2) or PET(O2) and PET(CO2) respectively), heart rate (HR) and O(2) arterial saturation by pulse oxymetry (SpO(2))] were measured throughout the tests. At the end of the tests, arterial blood samples were taken to measure arterial blood gases [O(2) and CO(2) arterial partial pressures ( Pa(O2) and Pa(CO2)), pH and O(2) arterial saturation (SaO(2))]. Results show that during HH compared to NH, f is greater (P

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“…After preoxygenation, decompression induced equal arterial desaturation, but significantly lower ventilation, lower blood pressure, and absent tachycardia. Two subjects showed reduced urine flow and increased urine osmolality only without preoxygenation (Tucker et al, 1983). The differences are most likely due to nitrogen bubble formation, which did not impair pulmonary function but did show possible prolonged CNS impairment.…”

Section: Cardiorespiratory Effects Of Gas Embolism With Rapid Decomprmentioning

confidence: 82%

Sightings

Severinghaus¹

2004

High Altitude Medicine & Biology

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Cardiopulmonary response to acute altitude exposure: Water loading and denitrogenation

Cited by 31 publications

References 29 publications

Renal Function and Fluid Homeostasis

Renal Function and Fluid Homeostasis

Normo- and hypobaric hypoxia: are there any physiological differences?

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