Cardiopulmonary Responses to Exercise in Chronic Airflow Obstruction

Brown, Stephen E.; Prager, Richard S.; Shinto, Richard A.; Fischer, Claudia; Stansbury, David W.; Light, Richard W.

doi:10.1378/chest.89.1.7

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…Thus, the chance of finding positive effects on the measured exercise parameters is enhanced. [23][24][25][26][27][28]30,31,33,35,39,42,44,47,53,55,59 In Figure 1, we show that a positive correlation exists between the mean level of reversibility in different studies and the respective mean improvement in 12-MWD. All together, when looking at Tables 2-6, the majority of studies did find a significant effect of bronchodilator therapy on FEV 1 .…”

Section: Discussionmentioning

confidence: 79%

A Systematic Review of the Effects of Bronchodilators on Exercise Capacity in Patients With COPD

Liesker¹,

Wijkstra²,

Hacken³

et al. 2002

Chest

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Section: Discussionmentioning

confidence: 79%

A Systematic Review of the Effects of Bronchodilators on Exercise Capacity in Patients With COPD

Liesker¹,

Wijkstra²,

Hacken³

et al. 2002

Chest

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“…Inhaled anticholinergic agents are recommended as the first-line drugs to relieve these patients' symptoms and to improve their airflow limitation (1,2). Although the bronchodilating effects of these drugs in COPD have been established (3,4), there is sometimes controversy about whether anticholinergic agents affect exercise performance (5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

“…In investigating the effects of bronchodilators on exercise performance in patients with COPD, a walking test and progressive cycle ergometry (PCE) are often used (5)(6)(7)(8)(9)(10). However, in assessing the effects of pulmonary rehabilitation, endurance tests are sometimes used because measures of endurance may be responsive to training.…”

mentioning

confidence: 99%

The Effects of Oxitropium Bromide on Exercise Performance in Patients with Stable Chronic Obstructive Pulmonary Disease

Oga

Nishimura

Tsukino

et al. 2000

Am J Respir Crit Care Med

166

115

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The purpose of the present study was to compare the characteristics of three different exercise tests in evaluating the effects of oxitropium bromide on exercise performance. Thirty-eight males with stable chronic obstructive pulmonary disease (COPD) (FEV(1) = 40.8 +/- 16.5% predicted; mean +/- SD) completed randomized, double-blind, placebo-controlled, crossover studies for each exercise test. The exercise tests were performed 60 min after the inhalation of either oxitropium bromide 400 microg or placebo. The patients performed 6-min walking tests (6MWT) on Days 1 and 2, progressive cycle ergometry (PCE) on Days 3 and 4, and cycle endurance tests at 80% of the maximal workload of PCE on Days 5 and 6. Spirometry was conducted before and at 45 and 90 min after the inhalation. Oxitropium bromide significantly increased FEV(1) as compared with placebo. Oxitropium bromide increased the endurance time significantly, by 19% (p < 0.001), and caused a small but significant increase in the 6-min walking distance by 1% (p < 0.05), but induced no significant increase in maximal oxygen consumption (V O(2)max) in PCE. The responses in these three exercise tests were different, and we conclude that the endurance test was the most sensitive in detecting the effects of inhaled anticholinergic agents on exercise performance in patients with stable COPD. An endurance procedure may be performed to detect clinical changes in evaluating the effects of oxitropium bromide on exercise performance.

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Chronic Bronchitis and Emphysema

MacNee¹

2000

Crofton and Douglas's Respiratory Diseases

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Cardiopulmonary Responses to Exercise in Chronic Airflow Obstruction

Cited by 12 publications

References 22 publications

A Systematic Review of the Effects of Bronchodilators on Exercise Capacity in Patients With COPD

A Systematic Review of the Effects of Bronchodilators on Exercise Capacity in Patients With COPD

The Effects of Oxitropium Bromide on Exercise Performance in Patients with Stable Chronic Obstructive Pulmonary Disease

Chronic Bronchitis and Emphysema

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