Background
Although hospitalized patients with advanced cancer have low chance of surviving cardiopulmonary resuscitation (CPR), the processes by which they change their code status from full code to Do-Not-Resuscitate (DNR) are unknown.
Methods
We conducted a mixed-methods study on a prospective cohort of hospitalized patients with advanced cancer. Two physicians used a consensus-driven medical record review to characterize processes leading to code status order transitions from full code to DNR.
Results
We reviewed 1047 hospitalizations among 728 patients. Admitting clinicians did not address code status in 53.0% of hospitalizations resulting in code status orders of ‘presumed full’. 275 patients (26.3%) transitioned from full code to DNR and 48.7% (134/275) of those had an order of ‘presumed full’ upon admission but upon further clarification, the patients expressed that they had wished to be DNR prior to the hospitalization. We identified three additional processes leading to order transition from full code to DNR: acute clinical deterioration (15.3%), discontinuation of cancer-directed therapy (17.1%), and education about the potential harms/futility of CPR (15.3%). Compared to discontinuing therapy and education, transitions due to acute clinical deterioration were associated with less patient involvement (P=0.002), shorter time to death (P<0.001), and higher likelihood of inpatient death (P=0.005).
Conclusions
Half of code status order changes among hospitalized patients with advanced cancer were due to full code orders in patients who had a preference for DNR prior to hospitalization. Transitions due to acute clinical deterioration were associated with less patient engagement and higher likelihood of inpatient death.