“…Eleven trials [8-12, 17, 19, 21, 23-25] were conducted in critically ill patients requiring ICU care; 5 trials used continuous RRT (CRRT) as a modality of treatment [8,[19][20][21]24], 5 trials utilized both CRRT and intermittent hemodialysis (IHD) [9,11,12,17,25], and 4 trials used IHD as a modality of RRT [7,18,22,23]. Four trials reported both day 30 and day 90 mortality [11,12,20,21], 6 trials reported day 30 mortality [8,12,17,19,24,28], and one trial reported day 90 mortality [25]. Three trials had low risk of bias in all domains [11,12,24], remaining 11 trials had unclear or high risk of bias in one or more of the following domains (random sequence generation, allocation concealment, blinding, incomplete outcome data, and reporting bias) (see online suppl.…”