Cardiopulmonary transit time: Reinforcing the case for positron emission tomography after heart transplantation

Vidula, Mahesh K.; Selvaraj, Senthil; Guerraty, Marie

doi:10.1007/s12350-020-02514-5

Cited by 1 publication

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References 8 publications

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“…Since most dedicated software packages for MBF calculation are standardized to place region of interest in left ventricular (LV) cavity to obtain TAC. The actual interval of perfusion tracer passing through LV in clinical dynamic study should be approximately less than two minutes ( 18 ), and this was the primal reason that the acquisition timing was set as 60 sec in our study. Other phantom study for 82 Rb, Renaud et al reported that approximately 3 to 14 MBq/kg dose of radioactivity is recommended as injected dose, and the counting rate should be 4 to 14 Mcps as recommendation ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Optimization of Intraventricular Radioactive Concentration for <sup>13</sup>N ammonia PET with Time-of-Flight Scanner

Kaimoto

Fukui

Kanaya³

et al. 2023

Annals of Nuclear Cardiology

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Background : Myocardial blood flow quantification (MBF) is one of the distinctive features for cardiac positron emission tomography. The MBF calculation is mostly obtained by estimating the input function from the time activity curve in dynamic scan. However, there is a substantial risk of count-loss because the high radioactivity pass through the left ventricular (LV) cavity within a short period. We aimed to determine the optimal intraventricular activity using the noise equivalent count rate (NECR) analysis with simplified phantom model. Methods : Positron emission tomography computed tomography scanner with LYSO crystal and time of flight was used for phantom study. 150 MBq/mL of 13 N was filled in 10 mL of syringe, placed in neck phantom to imitate end-systolic small LV. 3D list-mode acquisition was repeatedly performed along radioactive decay. Net true and random count rate were calculated and compared to the theoretical activity in the syringe. NECR curve analysis was used to determine the optimal radioactive concentration. Result : The attenuation curves showed good correlation to the theoretical activity between 20 to 370, and 370 to 740 MBq (r 2 =1.0 ± 0.0001, p<0.0001; r 2 =0.99 ± 0.0001, p<0.0001 for 20 to 370, and 370 to 740, respectively), while did not over 740 MBq (p=0.62). NECR analysis revealed that the peak rate was at 2.9 Mcps, there at the true counts were significantly suppressed. The optimal radioactive concentration was determined as 36 MBq/mL. Conclusion : Simulative analysis for high-dose of 13 N using the phantom imitating small LV confirmed that the risk of count-loss was increased. The result can be useful information in assessing the feasibility of MBF quantification in clinical routine.

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Section: Discussionmentioning

confidence: 99%

Optimization of Intraventricular Radioactive Concentration for <sup>13</sup>N ammonia PET with Time-of-Flight Scanner

Kaimoto

Fukui

Kanaya³

et al. 2023

Annals of Nuclear Cardiology

View full text Add to dashboard Cite

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Cardiopulmonary transit time: Reinforcing the case for positron emission tomography after heart transplantation

Abstract: Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Cited by 1 publication

References 8 publications

Optimization of Intraventricular Radioactive Concentration for <sup>13</sup>N ammonia PET with Time-of-Flight Scanner

Optimization of Intraventricular Radioactive Concentration for <sup>13</sup>N ammonia PET with Time-of-Flight Scanner

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