Cardiorenal Anemia Syndrome as a Prognosticator for Death in Heart Failure

Lu, K.; Kearney, L.; Hare, David; Ord, M.; Toia, Deidre; Jones, E.; Burrell, Louise M.; Srivastava, Piyush

doi:10.1016/j.amjcard.2012.12.049

Cited by 40 publications

(47 citation statements)

References 21 publications

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“…Both of these variables are known prognostic factors in HF patients [12,[21][22][23][28][29][30]. It seems possible that due to a relatively small number of events these factors did not reach statistical significance in our analysis.…”

Section: Discussioncontrasting

confidence: 45%

Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure

et al. 2014

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Background: Resting heart rate (HR) has been proven to influence long-term prognosis in patients with chronic heart failure (HF). (OR 1.594 [per 10 bpm]; p = 0.0248) and lower natrium concentration at admission (OR 0.767 [per 1 mmol/L]; p = 0.0162) were the only independent predictors of in-hospital mortality. Conclusions: In patients with HF, higher resting HR at hospital admission is associated with increased in-hospital mortality. (Cardiol J 2014; 21, 4: 425-433)

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Section: Discussioncontrasting

confidence: 45%

Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure

et al. 2014

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“…It has been demonstrated that any of the above-mentioned three conditions can contribute to the development and worsening of the other two conditions. 4 There are currently no data available on AHF and CRAS in the Arabian Gulf region. 2 The role of CRAS in acute HF (AHF) is scarcely investigated as almost all the previous studies were performed on chronic HF (CHF) patients.…”

Section: Introductionmentioning

confidence: 99%

Incidence and impact of cardiorenal anaemia syndrome on all‐cause mortality in acute heart failure patients stratified by left ventricular ejection fraction in the Middle East

et al. 2018

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AimsThis study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all‐cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East.Methods and resultsData were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012. CRAS was defined as AHF with estimated glomerular filtration rate of <60 mL/min and low haemoglobin (<13 g/dL for men or <12 g/dL for women). Analyses were performed using univariate and multivariate statistical techniques. The overall mean age of the cohort was 59 ± 15 years, 62% (n = 3081) were men, and 27% (n = 1319) had CRAS. Co‐morbid conditions were common including hypertension (n = 3014; 61%), coronary artery disease (n = 2971; 60%), and diabetes mellitus (n = 2449; 50%). A total of 79% (n = 3576) of the patients had AHF with reduced ejection fraction (HFrEF) (LVEF < 50%). CRAS patients were associated with major bleeding (1.29% vs. 0.6%; P = 0.017), blood transfusion (10.1% vs. 3.0%; P < 0.001), higher re‐admission rate for AHF at 3 months' follow‐up (27.6% vs. 18.8%; P < 0.001) and at 12 months' follow‐up (34.3% vs. 26.2%; P < 0.001). Multivariate logistic regression demonstrated that patients with CRAS were associated with higher odds of all‐cause mortality during hospital admission [adjusted odds ratio (aOR), 2.10; 95% confidence interval (CI): 1.34–3.31; P = 0.001], at 3 months' follow‐up (aOR, 1.48; 95% CI: 1.07–2.06; P = 0.018), and at 12 months' follow‐up (aOR, 1.45; 95% CI: 1.12–1.87; P = 0.004). Stratified analyses showed that CRAS patients with HFrEF were associated with higher odds of all‐cause mortality during hospital admission (aOR, 2.03; 95% CI: 1.20–3.45; P = 0.009) and at 12 months' follow‐up (aOR, 1.42; 95% CI: 1.06–1.89; P = 0.019) but not at 3 months' follow‐up (aOR, 1.43; 95% CI: 0.98–2.09; P = 0.063). However, in AHF patients with preserved ejection fraction (LVEF ≥ 50%), CRAS was not associated with higher odds of all‐cause mortality not only during hospital admission (aOR, 2.15; 95% CI: 0.84–5.55; P = 0.113) but also at 3 months' follow‐up (aOR, 1.87; 95% CI: 0.93–3.76; P = 0.078) and at 12 months' follow‐up (aOR, 1.59; 95% CI: 0.91–2.76; P = 0.101).ConclusionsThe incidence of CRAS was 27%. CRAS was associated with higher odds of all‐cause mortality in AHF patients in the Middle East, especially in those with HFrEF.

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“…In all studies on heart failure, the average hemoglobin level was lower in the group with chronic renal failure, which was associated with a risk of re-hospitalization and higher mortality rates. Lu et al 8 had reported a 4-year death rate of 51% in patients with cardiorenal anemia syndrome vs. 26% in those without the syndrome. Age and serum potassium were the predictive factors cardiorenal anemia syndrome progression among patients with heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…In all the studies that have been conducted, advanced age was a factor associated with the occurrence of the CRS. In the study by Lu et al, 8 mean age of patients with CRS was 77 ± 8 years.…”

Section: Discussionmentioning

confidence: 99%