Cardiorespiratory Fitness and Insulin Sensitivity Response to high-Intensity Interval Training in Overweight Postmenopausal Women

Nakagaki, Mariana Santoro

doi:10.23880/doij-16000152

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Insulin resistance was determined by the homeostasis (homeostasis model assessment -insulin resistance) (HOMA-IR), a product of fasting insulin (µUI/ mL) and fasting plasma glucose (mmol/L) divided by 22.5. It was adopted 3.5 as the upper limit of normal range [39].…”

Section: Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Brazilian Primary Care of T2D with Reactive-Homeostatic and Lifestyle Changing- Allostatic Approaches: A Cost-Effectiveness Data

Nakagaki¹

2018

AJSS

View full text Add to dashboard Cite

The Brazilian Health System is committed to offer free of charge medications for Diabetes, with the expenditure with prescription drug being the increasingly large component of overall health care costs of the Ministry of Health. The program for Hypertension and Diabetes (HiperDia) provides distribution of more than 15 medications for those two diseases. However, besides this onerous pharmaceutical care, Brazil is facing a greater burden of T2D. The lack of discontinuing the soaring T2D might be due to the lack of knowledge of underlying epigenetics of insulin resistance and, consequently the principles for its treatment. The homeostasis model adopted by physicians in restoring the "low level" of plasma glucose probably has been inappropriate because if one signal is suppressed by a drug, the brain compensates by driving all the others harder. By adding more drugs to a complex system increases the frequency of iatrogenesis and costs. Alternatively, the allostasis model can explain insulin resistance without postulating any true defect because blood glucose fluctuates according to match the ever-shifting prediction of what might be needed. Insulin resistance would be caused by prolonged exposure to high glucose level that reduces its receptor number and sensitivity. Additionally, insulin and other hormones that regulate fuel supply are modulated rigorously from the brain by standard signals for vigilance such as cortisol. Cortisol related signals are elevated during states of hypervigilance and of hyposatisfaction. For people of lower socioeconomic status potential sources of satisfaction are less available, but food is abundant and cheap. Elevated cortisol raises appetite for carbohydrate and fat and shifts the distribution of fat deposits toward the viscera and reduces insulin sensitivity. The allostasis model suggests that the brain overrides local negative feedback (metabolic satiety signals) and people eat. Obesity contributes to T2D as well as to metabolic syndrome and atherosclerosis creating a profoundly lethal cascade, and all follow the familiar epidemiological pattern of disrupted communities. The guiding principle for rational treatment of T2D, would be to reduce the need for vigilance and to restore small satisfactions. Among population-based strategies, diet and physical exercise are the pillars of T2D treatment. In our community-based dynamic cohort, the lifestyle change protocol with dietary counseling and supervised walking-jogging exercises, reduced T2D by four exercise protocols such as high intensity (75%), Academy (71.3%), Mixed (78.6%) and Hydro-gymnastic (34.3%). Besides effective, this allostatic model experience showed to be also a money-saving alternative to be implemented by the government.

show abstract

Section: Measurementsmentioning

confidence: 99%

“…high-intensity interval training on treadmill included 10 minutes of warm-up at 70% of maximum heart rate (HR max), followed by 4 series of 4 minutes each on 90% HR max with 3-min intervals between series for active recovery at 70 % of FC max. The HIT was conducted twice a week, in alternated days [39].…”

Section: Lifestyle Modification Protocolmentioning

confidence: 99%

Brazilian Primary Care of T2D with Reactive-Homeostatic and Lifestyle Changing- Allostatic Approaches: A Cost-Effectiveness Data

Nakagaki¹

2018

AJSS

View full text Add to dashboard Cite

show abstract

Treating Blood Hypertension in a Brazilian Community: Moving from Reactive Homeostatic Model to Proactive Allostatic Healthcare

Burini¹

2018

Ann Clin Hypertens

View full text Add to dashboard Cite

The responsiveness of hypertensive subjects to different types of physical exercises and length of intervention, has been investigated in samples of our dynamic cohort study ("Move for Health" program) based on spontaneous demand for healthy lifestyle with supervised exercises and dietary counseling. After clinical selection and baseline assessments they were spontaneously assigned to exercise protocols of strength (PAc) isolated or combined with endurance (walking) exercises (PMi) daily or in alternated days(PMiA), hydrogymnastics(PHy) and tread mill high-intensity exercises(PHit), applied during 10(experiment 1) and 20(experiment 2) weeks of intervention. Baseline demographic, socioeconomic, anthropometric and physical activity and fi tness characteristics were similar among protocols. Ten-week training improved VO2max. Similarly in all protocols while hand grip increased only in PAc. In average, there was a 16% reduction rate of hypertension rate from baseline with both, SBP and DBP, reduced by PHy and only SBP by the PMi. After adjustments hypertension was more reduced by PAc, PMi and PHy. In the 20-week experiment, higher SBP was similarly reduced by PAc or PMiA and DBP by PMiA, after adjustments. Hence, so far, our generated data suggest physical exercises as an effective tool for hypertension reduction, from 10 weeks to 3 year-long supervised protocols composed by surface or aquatic activities with strength or endurance exercises. PAc takes longer and shortperiod responsiveness can be achieved by either combined (strength-endurance) or hydrogymnastic exercises. Thus, exercise training is a time-and type-dependent tool, feasible, costless and scientifi c-based rheostaticallostatic alternative for the current "sick-care" drug-dependent homeostatic approach to hypertension med care.

show abstract

Cardiorespiratory Fitness and Insulin Sensitivity Response to high-Intensity Interval Training in Overweight Postmenopausal Women

Cited by 2 publications

References 0 publications

Brazilian Primary Care of T2D with Reactive-Homeostatic and Lifestyle Changing- Allostatic Approaches: A Cost-Effectiveness Data

Brazilian Primary Care of T2D with Reactive-Homeostatic and Lifestyle Changing- Allostatic Approaches: A Cost-Effectiveness Data

Treating Blood Hypertension in a Brazilian Community: Moving from Reactive Homeostatic Model to Proactive Allostatic Healthcare

Contact Info

Product

Resources

About