Cardiorespiratory Fitness and Mortality in Healthy Men and Women

Imboden, Mary T.; Harber, Matthew P.; Whaley, M. H.; Finch, W. Holmes; Bishop, Derron L.; Kaminsky, Leonard A.

doi:10.1016/j.jacc.2018.08.2166

Cited by 208 publications

(179 citation statements)

References 34 publications

Supporting

Mentioning

161

Contrasting

Unclassified

Order By: Relevance

“…This study elucidates a physiological aspect of importance for individuals using beta 2 ‐adrenergic agonists on a regular basis.

\overset{V}{true}

O 2max relative to body mass is a strong predictor of all‐cause mortality and endurance performance . Physicians treating asthmatic athletes should adhere to the Global Initiative For Asthma guidelines (2018 GINA guidelines; ginasthma.org) and show caution when treating asthmatics athletes to avoid impairing performance and aerobic adaptations to resistance or endurance training .…”

Section: Limitations and Perspectivementioning

confidence: 99%

“…V O 2max relative to body mass is a strong predictor of all-cause mortality and endurance performance. 40 Physicians treating asthmatic athletes should adhere to the Global Initiative For Asthma guidelines (2018 GINA guidelines; ginasthma.org) and show caution when treating asthmatics athletes to avoid impairing performance and aerobic adaptations to resistance or endurance training. 9 Furthermore, given the anabolic properties of beta 2 -adrenergic agonists and potential detrimental effects on muscle oxidative capacity, the present findings support the restrictions toward these substances in competitive sports.…”

Section: Limitations and Perspectivementioning

confidence: 99%

See 1 more Smart Citation

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

Lemminger

Jessen

Habib

et al. 2019

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

While beta2‐adrenoceptor stimulation has been shown to increase lean mass and to alter metabolic properties of skeletal muscle, adaptations in muscle oxidative enzymes and maximal oxygen uptake (trueV˙O2max) in response to beta2‐adrenergic agonist treatment are inadequately explored in humans, particularly in association with resistance training. Herein, we investigated beta2‐adrenergic‐induced changes in trueV˙O2max, leg and arm composition, and muscle content of oxidative enzymes in response to treatment with the selective beta2‐adrenergic agonist terbutaline with and without concurrent resistance training in young men. Forty‐six subjects were randomized to 4 weeks of lifestyle maintenance (n = 23) or resistance training (n = 23). Within the lifestyle maintenance and resistance training group, subjects received daily terbutaline (8 × 0.5 mg) (n = 13) or placebo (n = 10) treatment. No apparent treatment by training interactions was observed during the study period. Terbutaline increased leg and arm lean mass with the intervention, whereas no treatment differences were observed in absolute trueV˙O2max and incremental peak power output (iPPO). Treatment main effects were observed for trueV˙O2‐reserve (P < .05), trueV˙O2max relative to body mass (P < .05), trueV˙O2max relative to leg lean mass (P < .01), and iPPO relative to leg lean mass, in which terbutaline had a negative effect compared with placebo. Furthermore, content of electron transport chain complex I‐V decreased by 11% (P < .05) for terbutaline compared with placebo. Accordingly, chronic treatment with the selective beta2‐adrenergic agonist terbutaline may negatively affect trueV˙O2max and iPPO in relative terms, but not in absolute.

show abstract

“…This study elucidates a physiological aspect of importance for individuals using beta 2 ‐adrenergic agonists on a regular basis.

\overset{V}{true}

Section: Limitations and Perspectivementioning

confidence: 99%

Section: Limitations and Perspectivementioning

confidence: 99%

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

Lemminger

Jessen

Habib

et al. 2019

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

“…Evidence has consistently shown CRF to be a strong and independent predictor of chronic disease, including CVD, cancer, and all-cause mortality. [3][4][5][6][7] Several studies have shown CRF to be a better predictor of health outcomes in both healthy and clinical populations than traditional cardiovascular disease (CVD) risk factors that are commonly assessed clinically. 4,5 CRF is a modifiable risk factor that is influenced by lifestyle and health parameters, including exercise training status.…”

Section: Introductionmentioning

confidence: 99%

The Association between the Change in Directly Measured Cardiorespiratory Fitness across Time and Mortality Risk

Imboden

Harber

Whaley

et al. 2019

Progress in Cardiovascular Diseases

Self Cite

102

View full text Add to dashboard Cite

Background: The relationship between cardiorespiratory fitness (CRF) and mortality risk has typically been assessed using a single measurement, though some evidence suggests the change in CRF over time influences risk. This evidence is predominantly based on studies using estimated CRF (CRF e). The strength of this relationship using change in directly measured CRF over time in apparently healthy men and women is not well understood. Purpose: To examine the association of change in CRF over time, measured using cardiopulmonary exercise testing (CPX), with all-cause and disease-specific mortality and to compare baseline and subsequent CRF measurements as predictors of all-cause mortality. Methods: Participants included 833 apparently healthy men and women (42.9 ± 10.8 years) who underwent two maximal CPXs, the second CPX being ≥ 1 year following the baseline assessment (mean 8.6 years, range 1.0 to 40.3 years). Participants were followed for up to 17.7 (SD 11.8) years for all-cause-, cardiovascular disease-(CVD), and cancer mortality. Cox-proportional hazard models were performed to determine the association between the change in CRF, computed as visit 1 (CPX1) peak oxygen consumption (VO 2peak [mL•kg-1• min-1 ])visit 2 (CPX2) VO 2peak , and mortality outcomes. A Wald-Chi square test of equality was used to compare the strength of CPX1 to CPX2 VO 2peak in predicting mortality. Results: During follow-up, 172 participants died. Overall, the change in CPX-CRF was inversely related to all-cause, CVD, and cancer mortality (p<0.05). Each 1 mL•kg-1• min-1 increase was associated with a ~ 11, 15, and 16% (all p<0.001) reduction in allcause, CVD, and cancer mortality, respectively. The inverse relationship between CRF and allcause mortality was significant (p<0.05) when men and women were examined independently, after adjusting for years since first CPX, baseline VO 2peak , and age. Further, the Wald Chi-square test of equality found CPX2 VO 2peak to be a significantly stronger predictor of all-cause mortality than CPX1 VO 2peak (p<0.05). Conclusion: The change in CRF over time was inversely related to

show abstract

“…2 Furthermore, among apparently healthy populations, it is also a predictor of cardiovascular events and all-cause mortality. 3,4 For example, in a recent report in which 4153 adults participated, Imboden et al reported that CRF derived from cardiopulmonary exercise (CPX) testing was negatively associated with the risk of all-cause, cardiovascular and cancer mortality. 4 However, while directly measured CRF derived from CPX is the gold standard, apparently healthy individuals rarely have the opportunity to perform this.…”

Section: Reizo Babamentioning

confidence: 99%

“…3,4 For example, in a recent report in which 4153 adults participated, Imboden et al reported that CRF derived from cardiopulmonary exercise (CPX) testing was negatively associated with the risk of all-cause, cardiovascular and cancer mortality. 4 However, while directly measured CRF derived from CPX is the gold standard, apparently healthy individuals rarely have the opportunity to perform this. Therefore, it is quite natural that most past studies used estimated values of CRF derived from age, sex and anthropometric variables, as well as in some, from body composition and/or physical activity.…”

Section: Reizo Babamentioning

confidence: 99%

Do we have simple and accurate predictors of health outcomes in apparently healthy populations other than estimated peak oxygen uptake?

Baba

2019

European Journal of Preventive Cardiology

View full text Add to dashboard Cite

Cardiorespiratory Fitness and Mortality in Healthy Men and Women

Cited by 208 publications

References 34 publications

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

The Association between the Change in Directly Measured Cardiorespiratory Fitness across Time and Mortality Risk

Do we have simple and accurate predictors of health outcomes in apparently healthy populations other than estimated peak oxygen uptake?

Contact Info

Product

Resources

About

Cardiorespiratory Fitness and Mortality in Healthy Men and Women

Cited by 208 publications

References 34 publications

Effect of beta2‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

Effect of beta2‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

The Association between the Change in Directly Measured Cardiorespiratory Fitness across Time and Mortality Risk

Do we have simple and accurate predictors of health outcomes in apparently healthy populations other than estimated peak oxygen uptake?

Contact Info

Product

Resources

About

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men

Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men