Cardiorespiratory fitness diminishes the effects of age on white matter hyperintensity volume

Johnson, Nancy E.; Bahrani, Ahmed A.; Powell, David K.; Jicha, Gregory A.; Gold, Brian T.

doi:10.1371/journal.pone.0236986

Cited by 16 publications

(11 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Observational studies suggest that physical activity and exercise may limit WMH. Two systematic reviews found physical activity to be associated with less WMH [17,18], and the effect appeared particularly prominent in older adults [19,20]. Both participating in physical activity and aerobic exercise training can improve cardiorespiratory fitness, which is suggested as a central mechanism for the effect of training on the brain [21].…”

Section: Introductionmentioning

confidence: 99%

Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study

Arild

Vangberg

Nikkels

et al. 2022

Aging

View full text Add to dashboard Cite

We investigated if a five-year supervised exercise intervention with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) versus control; physical activity according to national guidelines, attenuated the growth of white matter hyperintensities (WMH). We hypothesized that supervised exercise, in particular HIIT, reduced WMH growth. Older adults from the general population participating in the RCT Generation 100 Study were scanned at 3T MRI at baseline (age 70-77), and after 1-, 3-and 5-years. At each follow-up, cardiorespiratory fitness was measured with ergospirometry, and physical activity plus clinical data collected. Manually delineated total WMH, periventricular (PWMH), deep (DWMH), and automated total white matter hypointensity volumes were obtained. No group by time interactions were present in linear mixed model analyses with the different WMH measurements as outcomes. In the combined exercise (MICT&HIIT) group, a significant group by time interaction was uncovered for PWMH volume, with a larger increase in the MICT&HIIT group. Cardiorespiratory fitness at the follow-ups or change in cardiorespiratory fitness over time were not associated with any WMH measure. Contrary to our hypothesis, taking part in MICT or HIIT over a five-year period did not attenuate WMH growth compared to being in a control group following national physical activity guidelines.

show abstract

Section: Introductionmentioning

confidence: 99%

Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study

Arild

Vangberg

Nikkels

et al. 2022

Aging

View full text Add to dashboard Cite

show abstract

“…Furthermore, age is an independent predictor of cardiovascular disease risk and therefore may explain its stronger association with WMH volume compared with PA (48). To further explore this complex relationship, authors have investigated the relationship between age, cardiorespiratory fitness (CRF; expressed as peak oxygen uptake (49)), and WMH volume. Johnson and colleagues (49) reported that CRF reduced the predictive effect of age on WMH, where older adults with greater CRF had lower WMH volume compared with older adults with lower CRF.…”

Section: Discussionmentioning

confidence: 99%

“…To further explore this complex relationship, authors have investigated the relationship between age, cardiorespiratory fitness (CRF; expressed as peak oxygen uptake (49)), and WMH volume. Johnson and colleagues (49) reported that CRF reduced the predictive effect of age on WMH, where older adults with greater CRF had lower WMH volume compared with older adults with lower CRF. Although PA is closely associated with CRF (50), CRF is a direct, physiological measurement associated with endothelial and autonomic function, and a stronger predictor of cardiovascular disease risk compared with PA (51).…”

Section: Discussionmentioning

confidence: 99%

Poststroke White Matter Hyperintensities and Physical Activity: A CANVAS Study Exploratory Analysis

Hung

Khlif

Kramer³

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

Purpose: White matter hyperintensities (WMHs) are associated with poststroke cognitive decline and mortality. Physical activity (PA) may decrease WMH risk by reducing vascular risk factors and promoting cerebral perfusion. However, the association between poststroke PA and WMH progression remains unclear. We examined the association between PA and WMH volume 12 months after stroke, and between PA and change in WMH volume between 3 and 12 months after stroke. Methods: We included ischemic stroke survivors from the Cognition And Neocortical Volume After Stroke cohort with available brain magnetic resonance imaging and objective PA data. Total, periventricular, and deep WMH volumes (in milliliters) were estimated with manually edited, automated segmentations (Wisconsin White Matter Hyperintensities Segmentation toolbox). Moderate-to-vigorous intensity PA (MVPA) was estimated using the SenseWear® Armband. Participants with MVPA ≥30 min•d −1 were classified as "meeting PA guidelines." We used quantile regression to estimate the associations between PA (MVPA and meeting PA guidelines) with WMH volume at 12 months and change in WMH volume between 3 and 12 months after stroke. Results: A total of 100 participants were included (median National Institutes of Health Stroke Scale 2; interquartile range, 1-4). MVPA was not associated with WMH volume. In univariable analysis, meeting PA guidelines was associated with lower total, periventricular, and deep WMH volumes by 3.0 mL (95% confidence interval (CI), 0.5-9.7 mL), 2.8 mL (95% CI, 0.5-7.1 mL), and 0.9 mL (95% CI, 0.1-3.0 mL), respectively. However, in multivariable analysis, meeting PA guidelines was not associated with WMH volume, and older age was associated with greater WMH volume at 12 months. PA was not associated with change in WMH volume. Conclusions: Meeting PA guidelines was associated with lower WMH volume at 12 months in univariable analysis, but not in multivariable analysis. Age consistently predicted greater WMH volume.

show abstract

“…Multiple systematic reviews have shown the positive effects of physical activity on human structural neuroplasticity. In general, higher cardiorespiratory fitness or doses of physical activity seem to have protective effects on gray matter 15 , 16 and white matter volumes 17 – 19 . Intriguingly, in light of the recent shift to home-based lifestyles, sedentariness is increasingly being shown as a separate risk factor.…”

Section: Introductionmentioning

confidence: 96%

Housing quality and behavior affect brain health and anxiety in healthy Japanese adults

Pineda

Kokubun

Ikaga

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in humans remains poorly understood. We therefore explored the interaction of housing quality, weekend/holiday sedentary behavior, brain structure, and anxiety in healthy Japanese adults. Whole-brain structural magnetic resonance imaging (MRI) methods based on gray matter volume and fractional anisotropy were used as markers for brain health. Correlation tests were conducted, and then adjusted for multiple comparisons using the False Discovery Rate method. Housing quality and weekend/holiday sedentary behavior were associated with fractional anisotropy, but not with gray matter volume. Fractional anisotropy showed significant associations with anxiety. Lastly, both weekend/holiday sedentary behavior and housing quality were indirectly associated with anxiety through fractional anisotropy. These results add to the limited evidence surrounding the relationship among housing, behavior, and the brain. Furthermore, these results show that behavior and housing qualities can have an indirect impact on anxiety through neurobiological markers such as fractional anisotropy.

show abstract

Cardiorespiratory fitness diminishes the effects of age on white matter hyperintensity volume

Cited by 16 publications

References 62 publications

Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study

Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study

Poststroke White Matter Hyperintensities and Physical Activity: A CANVAS Study Exploratory Analysis

Housing quality and behavior affect brain health and anxiety in healthy Japanese adults

Contact Info

Product

Resources

About