Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood

Tangeraas, Trine; Midtvedt, Karsten; Cvancarova, Milada; Hirth, Asle; Fredriksen, Per Morten; Tonstad, S.; Isaksen, Gunhild Aker; Bjerre, Anna

doi:10.1007/s00467-011-1898-6

Cited by 7 publications

(7 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the articles reviewed for this study, and the literature regarding exercise programmes for patients with obesity and other chronic paediatric diseases, such as cystic fibrosis 53 and renal transplantation, 54 , 55 there appears to be a consensus that rehabilitation programmes should have a duration of at least 12 weeks and a frequency of two to three times a week, with sessions lasting at least 40 minutes. We believe that the programmes should include aerobic, resistance, and flexibility training, as well as education and psychological intervention.…”

Section: Discussionmentioning

confidence: 99%

Paediatric cardiac rehabilitation in congenital heart disease: a systematic review

et al. 2012

View full text Add to dashboard Cite

Cardiac Rehabilitation Programmes in the paediatric population are greatly underutilised, and clinical research on this promising form of therapy has been limited. Questions remain regarding the optimal structure and efficacy of the programmes. The complex needs of this unique population also mandate that additional outcome measures, beyond serial cardiopulmonary exercise testing, be identified and studied.

show abstract

Section: Discussionmentioning

confidence: 99%

Paediatric cardiac rehabilitation in congenital heart disease: a systematic review

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The HENT study protocol of the transplanted patients was approved by the Regional Committee for Medical and Health Research Ethics in South‐Eastern Norway, and the study was carried out according to the Declaration of Helsinki. Details from the HENT study have previously been published .…”

Section: Methodsmentioning

confidence: 99%

Angiotensin II type 1 receptor antibodies in childhood kidney transplantation

Bjerre

Tangeraas

Heidecke

et al. 2016

Pediatric Transplantation

Self Cite

View full text Add to dashboard Cite

Angiotensin II type 1 receptor antibodies (AT 1 RAb) have emerged as non-HLA Ab present in patients with acute AMR and risk of graft loss. Furthermore, AT 1 RAb have been shown to increase angiotensin II sensitivity which may play a role in the development of CVD and hypertension. Data on AT 1 RAb in stable transplant recipients are lacking. The aim of this study was to analyze the levels of AT 1 RAb in a cohort of stable patients after kidney transplantation (tx) in childhood. A cross-sectional study of 30 children (median age 14, range 3-19 yr, median time since tx five yr) and 28 adults who were transplanted in childhood (median age 26, range 20-40 yr, median time since tx 18 yr) transplanted between 1993-2006 and 1983-2002, respectively, was performed. Healthy controls were 51 healthy children (5-8 yr) and 199 healthy donors (median age 56.5 yr, range 42-83 yr). Plasma AT 1 RAb were analyzed by immunoassay. Median total AT 1 RAb IgG concentration was significantly higher in the pediatric-tx group as compared to the adult-tx group (40.0 and 10.95 U/mL, p < 0.0001). For both groups, the tx group showed higher levels: the pediatric-tx group vs. control group (40.0 vs. 13.3 U/mL, p = 0.0006) and the adult-tx group vs. adult control group (10.95 vs. 6.5 U/mL, p < 0.0001). Age was the strongest indicator of high levels of AT 1 RAb IgG (p = 0.0003). AT 1 RAb total IgG levels are significantly higher in a stable pediatric-tx cohort as compared to adult-tx patients and healthy controls of comparable age groups. The relevance of our findings in relation to age, time since tx, previous or future rejection, and CVD risk merits future studies.

show abstract

“…It is of note that most of the clinical parameters in the transplant recipients were within normal range and GFR was relatively good, which has to be taken account when interpreting the results. This is one of the few prospective studies reporting physical performance in pediatric transplant recipients and the influence of clinical parameters upon it [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity

et al. 2022

View full text Add to dashboard Cite

Background History of chronic kidney disease and kidney transplantation is known to influence physical performance capacity. The aim of this study was to compare the physical performance of pediatric kidney transplant recipients to healthy controls and to find possible correlations between clinical parameters and physical performance capacity. Methods Twenty-four pediatric kidney transplant recipients (62.5% boys) were tested at a median age of 10.8 years. Physical performance capacity was tested with a test set including six different components assessing muscle endurance, strength, speed, and flexibility. The control group consisted of 273 healthy age-matched schoolchildren. Clinical parameters were collected as part of routine follow-up protocol. The majority of patients (62.5%) had congenital nephrotic syndrome of Finnish type (CNS) as primary diagnosis, and therefore, the results of CNS recipients were compared to the other disease groups. Results The physical performance capacity in pediatric kidney transplant recipients was lower compared to healthy controls. Surprisingly, no statistically significant correlation was found between graft function and physical performance capacity. The CNS patients scored worse than patients with other diagnoses in all test domains except for sit-and-reach and shuttle run, but the differences did not reach statistical significance. Conclusion The physical performance of pediatric kidney transplant recipients is reduced, especially in those with congenital nephrotic syndrome. Clinical parameters, including graft function, did not predict physical performance capacity, suggesting that the reduced physical performance seems to be of multivariable cause. Graphical abstract

show abstract

Cardiorespiratory fitness in young adults with a history of renal transplantation in childhood

Cited by 7 publications

References 49 publications

Paediatric cardiac rehabilitation in congenital heart disease: a systematic review

Paediatric cardiac rehabilitation in congenital heart disease: a systematic review

Angiotensin II type 1 receptor antibodies in childhood kidney transplantation

Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity

Contact Info

Product

Resources

About