Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome. A Prospective Study of Men and Women

LaMonte, M.J.; Barlow, C.E.; Jurca, R.; Kampert, J.B.; Church, T.S.; Blair, S.N.

doi:10.1016/j.accreview.2005.10.021

Cited by 98 publications

(126 citation statements)

References 19 publications

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“…Large cross-sectional studies consistently show that muscle strength is decreased in the metabolic syndrome, even after adjusting for cardiorespiratory fitness and other confounders [37][38][39]. A prospective study of 10,498 adults by the Cooper Institute showed that lower cardiorespiratory fitness predicted incident metabolic syndrome during a 5.7-year follow-up period [40]. Chronic excess GC levels may contribute to muscle weakness in both Cushing's and the metabolic syndrome.…”

Section: Muscle Strengthmentioning

confidence: 97%

Adrenal steroids and the metabolic syndrome

Thomson

Stump²,

Kurukulasuriya³

et al. 2007

Current Science Inc

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The many similarities between the metabolic syndrome and Cushing's syndrome led to the hypothesis that excess glucocorticoids (GC) are part of the pathogenesis linking their features. We review recent work that confirms the initial similarities (obesity, glucose intolerance, hypertension, and hyperlipidemia) and extends them to associated features of both syndromes (osteopenia, hypogonadism, leukocytosis, depression, and muscle weakness). Recent studies report that these features also occur in subclinical Cushing's syndrome, hypercortisolemic depression, and the transgenic overexpression of 11beta-hydoxysteroid dehydrogenase type 1 (11beta-HSD1) in mouse models of excess GC in adipose tissue. Reducing excess GC--in the clinical syndromes and in the mouse model-reverses many of these features. Because local tissue excess GC may have a central role in the pathogenesis of the metabolic syndrome, selective 11beta-HSD1 inhibitors are under active development by several pharmaceutical companies.

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Section: Muscle Strengthmentioning

confidence: 97%

Adrenal steroids and the metabolic syndrome

Thomson

Stump²,

Kurukulasuriya³

et al. 2007

Current Science Inc

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“…Eine niedrige körperliche Leistungsfähigkeit ist, unabhängig von anderen Risikofaktoren und unabhängig vom Geschlecht, mit einer signifikant höhe-ren Inzidenz des metabolischen Syndroms verbunden [268].…”

Section: Empfehlungenunclassified

Deutsche Leitlinie zur Rehabilitation von Patienten mit Herz-Kreislauferkrankungen (DLL-KardReha)

Bjarnason-Wehrens

Held²,

Hahmann³

et al. 2007

Clin Res Cardiol Suppl

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“…These reductions in physical activity and performance not only contribute to reduced energy expenditure but also likely have a direct impact on the development of increased cardiometabolic risk. In support of this notion, there is substantial evidence that links diminished physical activity and performance to increased cardiometabolic risk [7][8][9].…”

mentioning

confidence: 91%