Cardiorespiratory interactions during resistive load breathing

Calabrese, Pasquale; Perrault, Hélène; Dinh, Tuan Pham; Eberhard, André; Benchetrit, Gila

doi:10.1152/ajpregu.2000.279.6.r2208

Cited by 40 publications

(30 citation statements)

References 16 publications

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“…Hyperventilation impairs baroreflex modulation of HR and sympathetic nerve traffic (115). A change in respiratory pattern, for example during resistive load breathing, may itself affect respiratory sinus arrhythmia, independent of the arterial pressure changes accompanying respiration (11).…”

Section: Physiology Of the Baroreflex And Methods To Explore Its Funcmentioning

confidence: 99%

Arterial baroreflex function and cardiovascular variability: interactions and implications

Lanfranchi

Somers

2002

American Journal of Physiology-Regulatory, Integrative and Comp

257

183

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The arterial baroreflex contributes importantly to the short-term regulation of blood pressure and cardiovascular variability. A number of factors (including reflex, humoral, behavioral, and environmental) may influence gain and effectiveness of the baroreflex, as well as cardiovascular variability. Many central neural structures are also involved in the regulation of the cardiovascular system and contribute to the integrity of the baroreflex. Consequently, brain injuries or ischemia may induce baroreflex impairment and deranged cardiovascular variability. Baroreflex dysfunction and deranged cardiovascular variability are also common findings in cardiovascular disease. A blunted baroreflex gain and impaired heart rate variability are predictive of poor outcome in patients with heart failure and myocardial infarction and may represent an early index of autonomic activation in left ventricular dysfunction. The mechanisms mediating these relationships are not well understood and may in part be the result of cardiac structural changes and/or altered central neural processing of baroreflex signals.

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Section: Physiology Of the Baroreflex And Methods To Explore Its Funcmentioning

confidence: 99%

Arterial baroreflex function and cardiovascular variability: interactions and implications

Lanfranchi

Somers

2002

American Journal of Physiology-Regulatory, Integrative and Comp

257

183

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“…Calabrese et al (7) have shown that adding resistive loads throughout the entire breathing cycle, hence increasing negative ITP swings, resulted in an increase in total power of HRV. Noteworthy, the increase in HRV appeared to be correlated to an increase in the respiratory period during resistive breathing rather than due to changes in ITP.…”

Section: Interpretation Of Changes In Hrvmentioning

confidence: 99%

Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure

Valipour¹,

Schneider²,

Kössler³

et al. 2005

Journal of Applied Physiology

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. Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure. J Appl Physiol 99: [2137][2138][2139][2140][2141][2142][2143] 2005. First published July 7, 2005; doi:10.1152/japplphysiol.00003.2005.-To determine the dynamic effects of short-term nasal positive airway pressure (nPAP) on cardiovascular autonomic control, continuous recordings of noninvasively obtained hemodynamic measurements and heart rate variability (HRV) were obtained in 10 healthy subjects during frequency-controlled breathing (between 0.20 and 0.24 Hz) in supine posture under different pressures of nPAP ranging from 3 to 20 cmH 2O. HRV was assessed using spectral analysis of the R-R interval. The slope of the regression line between spontaneous systolic blood pressure and pulse interval changes was taken as an index of the sensitivity of arterial baroreflex modulation of heart rate (sequence method). Application of nPAP resulted in a pressure-dependent decrease of cardiac output and stroke volume (P Ͻ 0.05, ANOVA) and in an increase in total peripheral resistance (P Ͻ 0.03, ANOVA). Hemodynamic changes under increasing nPAP were accompanied by a decrease in total power of HRV despite mean R-R interval remaining unchanged. The overall decrease in HRV was accompanied by a reduction across all frequency bands when absolute units were used (P Ͻ 0.01). When the power of low frequency and high frequency was calculated in normalized units, a diminished high frequency and an increased low-to-high frequency ratio were observed (P Ͻ 0.05). Compared with low levels of nPAP, pressure levels of Ͼ10 cmH 2O were associated with a significant decline in the mean slope of spontaneous baroreceptor sequences (P Ͻ 0.04). These findings indicate that short-term administration of nPAP in normal subjects exerts significant alterations in R-R interval variability and spontaneous baroreflex modulation of heart rate. cardiac output; cardiovascular autonomic control; heart-lung interaction RESPIRATION SIGNIFICANTLY INFLUENCES autonomic cardiovascular control (12). During normal breathing, oscillatory changes of left ventricular stroke volume (SV) and arterial blood pressure (BP) are sensed by baroreceptors, which provoke parallel R-R interval changes by means of baroreflex physiology (27). Hemodynamic oscillations during normal (negative pressure) respiration are predominantly due to changes in intrathoracic pressure (ITP) (30). However, little is known about the effects of augmented positive ITP, which occurs with positive airway pressure (PAP) ventilation, on cardiovascular autonomic control. The application of PAP, both invasively or noninvasively, increases ITP and may result in a reduction in cardiac filling pressures (23,29,37,43). A reduction in cardiac filling pressures associated with PAP (or positive end-expiratory pressure) may induce a compensatory increase in vascular resistance to maintain systemic arterial pressure in the face of a reduced cardiac output (CO) (5, 41). The increase in...

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“…Resistive loads were added throughout the entire breath and for each recording, the value of the resistance was calculated from the mouth pressure versus flow plot throughout the total recording. The mean value (±SD) for all resistances on the 11 subjects were at rest R 0 = 0.75 (±0.03) for the apparatus resistance, R 1 = 3.26 (±0.25), R 2 = 5.27 (±0.34), R 3 = 8.23 (±0.43) and R 4 = 12.26 (±0.63) cm H 2 O l -1 s. The recordings were performed in a random order unknown to the subject and on two subjects (#4 and #10) only four recordings were performed (Calabrese et al 2000).…”

Section: Validation With Experimental Datamentioning

confidence: 99%

A Simple Dynamic Model of Respiratory Pump

et al. 2010

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To study the interaction of forces that produce chest wall motion, we propose a model based on the lever system of Hillman and Finucane (J Appl Physiol 63(3):951-961, 1987) and introduce some dynamic properties of the respiratory system. The passive elements (rib cage and abdomen) are considered as elastic compartments linked to the open air via a resistive tube, an image of airways. The respiratory muscles (active) force is applied to both compartments. Parameters of the model are identified in using experimental data of airflow signal measured by pneumotachography and rib cage and abdomen signals measured by respiratory inductive plethysmography on eleven healthy volunteers in five conditions: at rest and with four level of added loads. A breath by breath analysis showed, whatever the individual and the condition are, that there are several breaths on which the airflow simulated by our model is well fitted to the airflow measured by pneumotachography as estimated by a determination coefficient R(2) > or = 0.70. This very simple model may well represent the behaviour of the chest wall and thus may be useful to interpret the relative motion of rib cage and abdomen during quiet breathing.

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Cardiorespiratory interactions during resistive load breathing

Cited by 40 publications

References 16 publications

Arterial baroreflex function and cardiovascular variability: interactions and implications

Arterial baroreflex function and cardiovascular variability: interactions and implications

Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure

A Simple Dynamic Model of Respiratory Pump

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