Cardiorespiratory kinetics in exercise physiology: estimates and predictions using randomized changes in work rate

Abstract

Purpose Kinetics of cardiorespiratory parameters (CRP) in response to work rate (WR) changes are evaluated by pseudo-random binary sequences (PRBS testing). In this study, two algorithms were applied to convert responses from PRBS testing into appropriate impulse responses to predict steady states values and responses to incremental increases in exercise intensity. Methods 13 individuals (age: 41 ± 9 years, BMI: 23.8 ± 3.7 kg m−2), completing an exercise test protocol, comprising a section of randomized changes of 30 W and 80 W (PRBS), two phases of constant WR at 30 W and 80 W and incremental WR until subjective fatigue, were included in the analysis. Ventilation ($$\dot{V}_{{\text{E}}}$$ V ˙ E ), O2 uptake ($$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 ), CO2 output ($$\dot{V}{\text{CO}}_{2}$$ V ˙ CO 2 ) and heart rate (HR) were monitored. Impulse responses were calculated in the time domain and in the frequency domain from the cross-correlations of WR and the respective CRP. Results The algorithm in the time domain allows better prediction for $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and $$\dot{V}{\text{CO}}_{2}$$ V ˙ CO 2 , whereas for $$\dot{V}_{{\text{E}}}$$ V ˙ E and HR the results were similar for both algorithms. Best predictions were found for $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and HR with higher (3–4%) 30 W steady states and lower (1–4%) values for 80 W. Tendencies were found in the residuals between predicted and measured data. Conclusion The CRP kinetics, resulting from PRBS testing, are qualified to assess steady states within the applied WR range. Below the ventilatory threshold, $$\dot{V}{\text{O}}_{2}$$ V ˙ O 2 and HR responses to incrementally increasing exercise intensities can be sufficiently predicted.

Identifying time-varying dynamics of heart rate and oxygen uptake from single ramp incremental running tests

“…For instance, different non-linear model structures are proven to be successful (Stirling et al 2008, Zakynthinaki 2015. Moreover, characterizing impulse response functions has also demonstrated its capacities (Hoffmann et al 2022).…”