Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples

Gidlöf, Olof; Gilje, Patrik; vanderPals, Jesper; Götberg, Matthias; Erlinge, David

doi:10.1159/000328869

Cited by 227 publications

(217 citation statements)

References 59 publications

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“…In humans, 25 patients with MI revealed that all four miRNAs were increased in plasma, with a peak at 12 h. Peak values of miR-208b correlated with peak troponin levels. miR-1 and miR-133a both correlated strongly with renal elimination, which was confirmed by detection of miR-1 and miR-133a, but not miR-208b or miR-499-5p, in the urine [85] .…”

Section: Plasma and Urine Mirnasmentioning

confidence: 57%

miRNome in myocardial infarction: Future directions and perspective

Boštjančič

Glavač

2014

WJC

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MicroRNAs (miRNAs), which are small and non-coding RNAs, are genome encoded from viruses to humans. They contribute to various developmental, physiological and pathological processes in living organisms. A huge amount of research results revealed that miRNAs regulate these processes also in the heart. miRNAs may have cell-type-specific or tissue-specific expression patterns or may be expressed ubiquitously. Primary studies of miRNA involvement in hypertrophy, heart failure and myocardial infarction analyzed miRNAs that are enriched in or specific for cardiomyocytes; however, growing evidence suggest that other miRNAs, not cardiac or muscle-specific, play a significant role in cardiovascular disease. Abnormal miRNA regulation has been shown to be involved in cardiac diseases, suggesting that miRNAs might affect cardiac structure and function. In this review, we focus on miRNAs that have been found to contribute to the pathogenesis of myocardial infarction (MI) and the response post-MI and characterized as diagnostic, prognostic and therapeutic targets. The majority of these studies were performed using mouse and rat models of MI, with a focus on the identification of basic cellular and molecular pathways involved in MI and in the response post-MI. Much research has also been performed on animal and human plasma samples from MI individuals to identify miRNAs that are possible prognostic and/or diagnostic targets of MI and other MI-related diseases. A large proportion of research is focused on miRNAs as promising therapeutic targets and biomarkers of drug responses and/or stem cell treatment approaches. However, only a few studies have described miRNA expression in human heart tissue following MI.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: MicroRNAs; Myocardial infarction; Human; Animal models; Biomarkers and targets Core tip: MicroRNAs (miRNAs) contribute to various developmental, physiological and pathological processes in the heart. Cardiac diseases show abnormal miRNA regulation. Primary studies of miRNA involvement in cardiac disease analyzed mainly miRNAs that enriched in or specific for cardiomyocytes; however, growing evidence suggests that other cell-type-specific or ubiquitously expressed miRNAs are also involved in cardiovascular disease. miRNAs were found to contribute to the pathogenesis of myocardial infarction (MI) and post-MI. The majority of studies focused on miRNAs in animal models of MI, in human and animal plasma samples of MI (prognostic and diagnostic targets), and on miRNAs as promising therapeutic targets.Boštjančič E, Glavač D. miRNome in myocardial infarction: Future directions and perspective. World J Cardiol 2014; 6(9): 939-958 Available from:

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Section: Plasma and Urine Mirnasmentioning

confidence: 57%

miRNome in myocardial infarction: Future directions and perspective

Boštjančič

Glavač

2014

WJC

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“…20 Analysis of 25 patients with ST elevation myocardial infarction (STEMI) revealed that miR-208b strongly correlated with troponin level and the ejection fraction. 21 In the same study authors registered high level of miR-1, miR-133a, miR-208b and miR-499-5p in plasma of patients, and what more interesting, miR-1and miR-133a was detected in urine of patient with STEMI. 21 This data indicate that not only circulating miRNAs in blood but also in other fluids like urine are very promising for heart pathology diagnosis.…”

Section: Introductionmentioning

confidence: 79%

“…21 In the same study authors registered high level of miR-1, miR-133a, miR-208b and miR-499-5p in plasma of patients, and what more interesting, miR-1and miR-133a was detected in urine of patient with STEMI. 21 This data indicate that not only circulating miRNAs in blood but also in other fluids like urine are very promising for heart pathology diagnosis. Other group of authors identified four miRNAs which strongly discriminated patients with chronic heart failure from controls: miR-660-3p, miR-665, miR-1285-3p and miR-4491.…”

Section: Introductionmentioning

confidence: 79%

Future Perspectives in Heart Pathology Diagnosis and Therapy. How We Can Use the Micro RNA?

Piven

2017

ATROA

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Heart disease is the number one cause of death worldwide with the number of people diagnosed ever increasing due to an ageing population also has a great social and economic impact. Recently, the investigation of new method of diagnosis and treatment of cardiovascular diseases are become topical, but also the elucidation of they own mechanisms are in focus. Beside of known signaling pathways which involved in heart pathology the miRNA is actively investigated as potential regulator of molecular mechanisms in heart including disease. Based on short review of experimental data we proposed that miRNA has a huge potency for early heart pathology diagnosis as markers.Keywords: heart, microRNAs, signaling networks, heart pathology, early diagnosis

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“…Four studies so far in European populations in vivo 32: 313-318 (2018) correlating altered miR expression with specific types of myocardial infarction are reported in the literature: a Swedish, a Belgian, an Italian and a German. In the study of Gidlöf et al (27), miR-208b and miR-499 increased abruptly in plasma of ST elevation myocardial infarction (STEMI) patients, but not in their urine. Furthermore, Devaux and his colleagues found miR-208b and miR-499 highly increased in MI patients and nearly undetectable in healthy controls (28).…”

Section: Plasma Levels Of Mir208b (A) and Mir499 (B) Were Significantmentioning

confidence: 99%

Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

Αγιαννιτόπουλος

Pavlopoulou

Tsamis

et al. 2018

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Abstract. Background/Aim: Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) MicroRNAs (miRs) are evolutionary small endogenous, noncoding, single-stranded RNAs involved in the regulation of gene expression at the post-transcriptional level (1). They possess an important role in multiple biological processes by binding to their target mRNAs and altering the protein expression of their candidate targets (2). Circulating miRs detected in serum or plasma, are actively secreted in macrovesicles or exosomes from different cell types (3), including cardiomyocytes. Elevated mRNA expression levels have been involved in numerous human pathologies including cardiovascular diseases (4).Acute myocardial infarction (AMI) is the acute necrosis of myocardial tissue due to persistent and severe ischemia, and remains a leading cause of morbidity and mortality worldwide (5). Accurate and rapid diagnosis is crucial for the clinical management and prognosis of AMI (6). Thus, exploration of new potential biomarkers that will contribute in this direction is particularly important. Although the circulating levels of cardiac troponin proteins are currently regarded as the most prominent biomarkers for the diagnosis of AMI, measurable amounts of troponins are not usually released from damaged myocardium earlier than 4-8 h after the onset of symptoms (6, 7). In contrast, the levels of circulating plasma miRs can be measured rapidly using realtime PCR, offering two main advantages over standard antibody-based assays: increased sensitivity and specificity. Several studies have already considered circulating cardiacspecific or -enriched miRs as new biomarkers for the early diagnosis of .In fact, the vast majority of these studies have been performed in Asian populations, while limited studies from European populations are also available (12). Consequently, better validation through larger studies is required for the establishment of miRs as biomarkers in clinical practice. Based on the elegant study of Huang et al. (13) who showed that miRNA expression levels exhibit population differences, and the recorded dysregulation of two specific myocardialderived miRNAs in AMI patients (14, 15), we decided to further investigate their expression in a Caucasian population. Specifically, the purpose of this study was to 313

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Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples

Cited by 227 publications

References 59 publications

miRNome in myocardial infarction: Future directions and perspective

miRNome in myocardial infarction: Future directions and perspective

Future Perspectives in Heart Pathology Diagnosis and Therapy. How We Can Use the Micro RNA?

Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

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