Cardiotone Wirkstoffe ausSpigelia anthelmia¹

Abstract

From the upper parts of SPIGELIA ANTHELMIA L. besides some widely distributed phenolcarboxylic acids and flavonoids two volatile alkaloids have been isolated and identified as isoquinoline and an iridoid compound of the actinidine type. In the water extract choline, benzoylcholine and 3,3-dimethyl-acryloylcholine could be identified. Preliminary pharmacological investigations revealed that the alkaloids are involved in the cardiotonic activity of the plant.

Neuromuscular effects and acute toxicity of an ethyl acetate extract of Spigelia anthelmia Linn.

“…Previous phytochemical investigations of the plant have described the isolation of an alkaloid named spiganthine (Hegnauer, 1966) and isoquinoline, actinidine, choline and acylated cholines and flavonoids (Wagner et al, 1986). Other minor constituents, chemically related to the alkaloids rianodine and spiganthine, were isolated and evaluated for their activity on the papillary cardiac muscle of guinea-pigs, inducing delay of the latency to contraction qualitatively similar to that obtained with ryanodine and spinganthine, but with different potencies (Hübner et al, 2001).…”

Spiganthine, the Cardioactive Principle of Spigelia anthelmia

“…Previous phytochemical investigations have described the isolation of an alkaloid named "spigeliin" with a still unknown chemical structure (9,10). More recently, a research group has investigated the constituents of the plant's aerial parts and isolated isoquinoline, actinidine, choline, and acylated cholines along with flavonoids and acids derived from the shikimic acid pathway (11).…”