Cardiotoxic and Bronchoconstrictor Effects of Industrial Metal Fumes Containing Barium

Hicks, R.; Caldas, L. Q. A. de; Dare, Philip R.M.; Hewitt, Peter J.

doi:10.1007/978-3-642-71248-7_84

Cited by 30 publications

(13 citation statements)

References 2 publications

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“…It is most often the result of accidental or suicidal ingestion of the rodenticide, barium carbonate [Johnson and VanTassel, 1991]. Barium intoxication has also been reported as a result of absorption through a chemical burn [Stewart and Hummel, 1984] and inhalation of metal fumes [Hicks et al, 1986]. This case was caused by an explosion of barium styphnate with transcutaneous and pulmonary absorption.…”

Section: Discussionmentioning

confidence: 99%

Poisoning as a result of barium styphnate explosion*

Jacobs

Taddeo

Kelly

et al. 2002

American J Industrial Med

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Section: Discussionmentioning

confidence: 99%

Poisoning as a result of barium styphnate explosion*

Jacobs

Taddeo

Kelly

et al. 2002

American J Industrial Med

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“…Compounds of barium are used as flux components for certain metal arc-welding processes. Hicks et al (1986) demonstrated that exposure to solutions of barium salts in anesthetized guinea pigs produced marked elevation in resistance to ventilatory airflow, and electrocardiograph (ECG) abnormalities indicating myocardial hyperexcitability. Nickel, a metal commonly found in welding factories, has potential cardiotoxicity, while all- trans -retinoid acid promote myocardial recovery (Lou et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Alterations in Cardiomyocyte Function After Pulmonary Treatment with Stainless Steel Welding Fume in Rats

Popstojanov

Antonini

Salmen

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Welding fume is composed of a complex of different metal particulates. Pulmonary exposure to different welding fumes may exert a negative impact on cardiac function, although the underlying mechanisms remain unclear. To explore the effect of welding fumes on cardiac function, Sprague-Dawley rats were exposed by intratracheal instillation to 2 mg/rat of manual metal arc hard surfacing welding fume (MMA-HS) once per week for 7 wk. Control rats received saline. Cardiomyocytes were isolated enzymatically at d 1 and 7 postexposure. Intracellular calcium ([Ca2+]i) transients (fluorescence ratio) were measured on the stage of an inverted phase-contrast microscope using a myocyte calcium imaging/cell length system. Phosphorylation levels of cardiac troponin I (cTnI) were determined by Western blot. The levels of nonspecific inflammatory marker C-reactive protein (CRP) and proinflammatory cytokine interleukin-6 (IL-6) in serum were measured by enzyme-linked immunosorbent assay (ELISA). Contraction of isolated cardiomyocytes was significantly reduced at d 1 and d 7 postexposure. Intracellular calcium levels were decreased in response to extracellular calcium stimulation at d 7 postexposure. Changes of intracellular calcium levels after isoprenaline hydrochloride (ISO) stimulation were not markedly different between groups at either time point. Phosphorylation levels of cTnI in the left ventricle were significantly lower at d 1 post-exposure. The serum levels of CRP were not markedly different between groups at either time point. Serum levels of IL-6 were not detectable in both groups. Cardiomyocyte alterations observed after welding fume treatment were mainly due to alterations in intracellular calcium handling and phosphorylation levels of cTnI.

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“…Industrial metal fumes containing barium have cardiotoxic effects. 77 Other industrial processes, such as metal hardening, arc-welding, ceramic glazing, or enameling, may give rise to barium-containing airborne particulate fumes and aerosols, which have a doseÀeffect toxic relationship. Other toxic heavy metals (e.g., lead, cadmium, mercury, and chromium) are dealt with in Section 1.19.…”

Section: Toxic Military and Industrial Chemicalsmentioning

confidence: 99%

Epidemiology of Cardiovascular Toxins

Onen

2015

Heart and Toxins

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Cardiotoxic and Bronchoconstrictor Effects of Industrial Metal Fumes Containing Barium

Cited by 30 publications

References 2 publications

Poisoning as a result of barium styphnate explosion*

Poisoning as a result of barium styphnate explosion*

Alterations in Cardiomyocyte Function After Pulmonary Treatment with Stainless Steel Welding Fume in Rats

Epidemiology of Cardiovascular Toxins

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