Cardiotoxicité du lindane, un isomère γ de l’hexachlorocyclohexane

Sauviat, Martin-Pierre; Pagès, Nicole

doi:10.1051/jbio/2002196040339

Cited by 20 publications

(11 citation statements)

References 62 publications

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“…Lindane is known to cause neurological, immunological, reproductive and cancerogenic effects. It is also an EDC causing hormonal imbalances in human males (Sauviat and Pages, 2002;ATSDR, 2005).…”

Section: Discussionmentioning

confidence: 99%

Organochlorine pesticide levels in Clarias gariepinus from polluted freshwater impoundments in South Africa and associated human health risks

Barnhoorn

Dyk

Genthe³

et al. 2015

Chemosphere

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HighlightsClarias gariepinus muscle tissue bio-accumulated organochlorine pesticides. Predicted risk of developing cancer is higher than the recommended safe value of 1. The Roodeplaat Dam risk is as a result of muscle levels of dieldrin and aldrin. Non-carcinogenic risks were 2 to 6 times that of the level considered to be safe. Keywords:Muscle tissue, Organo-chlorine pesticides Human health, Cancer risk, Toxic risk, Fish consumption AbstractThere are increasing concerns regarding the safe human consumption of fish from polluted, freshwater impoundments. The aim of this study was to analyse the muscle tissue of the sharptooth catfish Clarias gariepinus for selected organo-chlorine pesticides (OCPs) and to perform a human health risk assessment using a standard protocol described by the United States Environmental Protection Agency (US EPA). Fish were collected from the polluted Roodeplaat-(RDPD), Rietvlei-(RVD) and Hartbeespoort (HBPD) Dam impoundments located in the north-eastern regions of South Africa. GC-MS analyses showed levels of various OCPs in fish muscle samples from all three impoundments. For fish collected from the RDPD, p,p 0 -DDE, endosulfan, lindane and band d-HCH were the most prevalent OCPs detected, while p,p 0 -DDE and endosulfan were the most predominant in fish from the RVD. Lindane and b-and d-HCH were the main OCPs detected in fish from the HBPD. Dieldrin was the only OCP detected at concentrations for which a cancer risk and a hazard index above the acceptable risk levels were estimated. This was the case for fish from both the RDPD and RVD impoundments. No toxic risk was estimated should fish from the HBPD be consumed.

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Section: Discussionmentioning

confidence: 99%

Organochlorine pesticide levels in Clarias gariepinus from polluted freshwater impoundments in South Africa and associated human health risks

Barnhoorn

Dyk

Genthe³

et al. 2015

Chemosphere

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“…Their exaggerated cholinergic stimulation increases the vagal nerve effect on the heart rate and induces bradycardia and slowed cardiac conduction, leading to a decrease in cardiac output [10].…”

Section: Resultsmentioning

confidence: 99%

Role of quinidine therapy after dimethoate acute intoxication in the rat diaphragm

Abunasef

Aal

2015

The Egyptian Journal of Histology

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“…Marked deleterious effects of lindane on liver of treated rats were evident by increased activities of enzymes of liver function tests such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (Prasad and Soni, 2005). Lindane produces histological alterations of cardiac tissues and a cardio-vascular dystrophy (contracture, degenerescence and necrosis) mainly in the left ventricular wall and a hypertrophy of the left ventricle (Sauviat and Pages, 2002). DNA binding and mutagenicity of lindane and its metabolites was reported by Gopalaswamy and Nair (1992).…”

Section: Effects On Humansmentioning

confidence: 98%

“…Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA A receptor-chloride channel complex at the picrotoxin binding site (Pomes et al, 1994;Narahashi, 1996). In humans, lindane affects the nervous system, liver and kidneys, and is carcinogenic (Smith, 1991;Sauviat and Pages, 2002). Marked deleterious effects of lindane on liver of treated rats were evident by increased activities of enzymes of liver function tests such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (Prasad and Soni, 2005).…”

Section: Effects On Humansmentioning

confidence: 99%

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Microbial degradation of gamma-hexachlorocyclohexane (lindane)

Girish¹,

Kunhi²

2013

Afr. J. Microbiol. Res.

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Organochloride compounds are known to be highly toxic and persistent, causing serious water and soil pollution. Hexachlorocyclohexane (HCH) is the term which collectively identifies the eight isomers of the hexachlorocyclohexane and they are denoted by the greek letters α, β, γ, δ, etc. Among the eight isomers, gamma-hexachlorocyclohexane (γ-HCH or lindane), is the only one with insecticidal properties. γ-HCH has been mainly used in agriculture and vector control programmes. HCH isomers are recognized for their toxicity, persistence in the environment and potential carcinogenic effects. Lindane is a neurotoxin that interferes with GABA neurotransmittor function. In humans, lindane affects the nervous system, liver and kidneys, and may be a carcinogen. Because of this, lindane, a cheap and effective insecticide, is banned in many other countries, while still being used or have been banned only recently in India. Their extensive use has resulted in a widespread occurrence of residues in the environment and in food products. Residues of γ-HCH have been reported from different soil and water systems in India. Efforts have been made for the remediation of soils and groundwater contaminated with the toxic and persistent HCH isomers through biodegradation processes. Microorganisms capable of degrading HCH isomers have received considerable attention as they provide the possibility to be utilized for in situ detoxification. γ-HCH degrading microorganisms, many bacteria and a few fungi, have been isolated and employed for bioremediation of lindane contaminated soil and water systems. The genes and enzymes involved in the γ-HCH degradation pathway have been investigated.

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Cardiotoxicité du lindane, un isomère γ de l’hexachlorocyclohexane

Cited by 20 publications

References 62 publications

Organochlorine pesticide levels in Clarias gariepinus from polluted freshwater impoundments in South Africa and associated human health risks

Organochlorine pesticide levels in Clarias gariepinus from polluted freshwater impoundments in South Africa and associated human health risks

Role of quinidine therapy after dimethoate acute intoxication in the rat diaphragm

Microbial degradation of gamma-hexachlorocyclohexane (lindane)

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