Cardiotoxicity and cardiovascular disease risk assessment for patients receiving breast cancer treatment

Clark, Robyn; Marin, Tania; Berry, Narelle M.; Atherton, J.; Foote, Jonathon; Koczwara, Bogda

doi:10.1186/s40959-017-0025-7

Cited by 24 publications

(19 citation statements)

References 19 publications

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“…Currently, there is an increasing amount of evidence that cancer and CVD share not only the risk factors but also the mechanism of pathogenicity [4,5]. This is confirmed mainly in the case of breast cancer by the increased cardiac risk in patients receiving chemotherapy and radiotherapy as well as in cancer survivors [6][7][8][9][10]. It is also plausible that cancer itself may deleteriously affect heart function, irrespective of exposure to anticancerogenic therapies.…”

Section: Introductionmentioning

confidence: 99%

Maternal and Early Postnatal Diet Supplemented with Conjugated Linoleic Acid Isomers Affect Lipid Profile in Hearts of Offspring Rats with Mammary Tumors

Białek

Czauderna

2020

Animals

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Linking the early life environment with later health status is known as “developmental programming”. This study aimed to assess whether the introduction of conjugated linoleic acids (CLAs) into the maternal diet affects the content fatty acids (FAs), conjugated FAs (CFAs), cholesterol, oxysterols, malondialdehyde (MDA) and tocopherols in the hearts of their female offspring treated with 7,12-dimethylbenz[a]anthracene and if offspring supplementation enhanced the effect of maternal supplementation. FA, cholesterol and oxysterol contents were determined by gas chromatography-mass spectrometry, while contents of CFAs and MDA were determined by high-performance liquid chromatography (HPLC) with photodiode detection. The supplementation of mothers with CLAs significantly decreased the amount of atherogenic saturated FAs and enhanced the level of eicosapentaenoic FA in the hearts of offspring. Continuous progeny supplementation decreased the content of arachidonic acid in hearts. Supplementation of the maternal diet with CLAs and its continuation during the postnatal period increased the ratio of hypo to hypercholesterolemic FAs. Significantly fewer oxysterols were detected in the hearts of progeny of dams fed with CLAs as compared to the offspring of mothers receiving safflower oil. Both fetal and postnatal CLA intake significantly reduced 7β-hydroxycholesterol accumulation. It can be concluded that CLA supplementation during the fetal and postnatal period may be an effective method of maintaining the cardiac health status of newborns.

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Section: Introductionmentioning

confidence: 99%

Maternal and Early Postnatal Diet Supplemented with Conjugated Linoleic Acid Isomers Affect Lipid Profile in Hearts of Offspring Rats with Mammary Tumors

Białek

Czauderna

2020

Animals

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“…Cardiovascular diseases (CVDs) remains number one of the fatal diseases, which is ever increasing worldwide and hence, scientific community has concerned about it [1,2]. Cardiotoxicity occurs as a result of the complicated working of cardiac cells and tissues or due to a chemical molecule affecting heart function and structure [3,4]. Cardiotoxicity induced by drugs has gained attention in the past few decades.…”

Section: Introductionmentioning

confidence: 99%

Two novel anticancer compounds with minimum cardiotoxic property

Afsharirad

Tahmasvand

Amini

et al. 2020

BMC Pharmacol Toxicol

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Background Although two novel synthesized compounds with tri-aryl structures; 3-(4-chlorophenyl)-5-(4-fluorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (A) and 3,5-bis-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (B) have been previously demonstrated to possess remarkable anti-breast cancer activity, their cardiotoxicity remains a major concern due to their mechanism of action. To address this concern, we assessed the ability of these compounds to cause toxicity towards H9c2 cardiomyocytes as an in vitro model of cardiotoxicity. Methods Cytotoxic activity of both compounds was explored in vitro on H9c2 cells using MTT assay. Annexin V/PI method, intracellular ROS determination and mitochondrial membrane potential assay were applied to elucidate the mechanism of action of the cell death. Results MTT assay revealed a concentration- and time-dependent cardiotoxicity. Findings of apoptosis by double staining with annexin V and propidium iodide divulged no cell death including apoptosis and necrosis at the concentration that were effective to inhibit cancer cells proliferation (10 μM) at 24 and 48 h. Furthermore, flow cytometric measurement of membrane potential and ROS determination using DCFH-DA verified the safe concentration of the compounds against H9c2 cells with no cardiotoxic effect. However, the higher concentration of the compounds could induce cell death through ROS-mediated mitochondrial dysfunction. Conclusions Altogether, the results represented two novel chemical molecules possessing anti-breast cancer activity with minimum cardiac side effect.

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“…Rate of cardiovascular diseases (CVDs) remains number one of the fatal diseases, which is ever increasing worldwide and hence, scienti c community has concerned about it [1,2]. Cardiotoxicity occurs as a result of the complicated working of cardiac cells and tissues or due to a chemical molecule affecting heart function and structure [3,4]. Cardiotoxicity induced by drugs has gained attention in the past few decades.…”

Section: Introductionmentioning

confidence: 99%

Two novel anticancer compounds with minimum cardiotoxic property

Afsharirad

Tahmasvand

Amini

et al. 2020

Preprint

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Background: Although two novel synthesized compounds with tri-aryl structures (A and B) have been previously demonstrated to possess remarkable anti-breast cancer activity, their cardiotoxicity remains a major concern due to their mechanism of action. To address this concern, we assessed the ability of these compounds to cause toxicity towards H9c2 cardiomyocytes as an in vitro model of cardiotoxicity. Methods: Cytotoxic activity of both compounds was explored in vitro on H9c2 cells using MTT assay. Annexin V/PI method, intracellular ROS determination and mitochondrial membrane potential assay were applied to elucidate the mechanism of action of the cell death. Results: MTT assay revealed a concentration- and time-dependent cardiotoxicity. Findings of apoptosis by double staining with annexin V and propidium iodide divulged no cell death including apoptosis and necrosis at the concentration that were effective to inhibit cancer cells proliferation (10 µM) at 24 and 48 hours. Furthermore, flow cytometric measurement of membrane potential and ROS determination using DCFH-DA verified the safe concentration of the compounds against H9c2 cells with no cardiotoxic effect. However, the higher concentration of the compounds could induce cell death through ROS-mediated mitochondrial dysfunction. Conclusions: Altogether, the results represented two novel chemical molecules possessing anti-breast cancer activity with minimum cardiac side effect.

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Cardiotoxicity and cardiovascular disease risk assessment for patients receiving breast cancer treatment

Cited by 24 publications

References 19 publications

Maternal and Early Postnatal Diet Supplemented with Conjugated Linoleic Acid Isomers Affect Lipid Profile in Hearts of Offspring Rats with Mammary Tumors

Maternal and Early Postnatal Diet Supplemented with Conjugated Linoleic Acid Isomers Affect Lipid Profile in Hearts of Offspring Rats with Mammary Tumors

Two novel anticancer compounds with minimum cardiotoxic property

Two novel anticancer compounds with minimum cardiotoxic property

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