Cardiotoxicity and neurobehavioral effects induced by acrylamide in Daphnia magna

Eghan, Kojo; Lee, Sang‐Woo; Kim, Woo‐Keun

doi:10.1016/j.ecoenv.2022.113923

Cited by 11 publications

(2 citation statements)

References 42 publications

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“…Long-term accumulation of MB in D. magna may lead to physiological abnormalities, decreased heart rate, and diminished eating capacity. Similar findings were reported by Eghan et al [ 40 ], who observed time- and dose-dependent suppression of heart rate and thoracic limb beat frequency in D. magna exposed to acrylamide. Bownik et al [ 41 ] also reported a time- and dose-dependent decrease in heart rate and thoracic limb beat frequency in response to ketoprofen, while procaine penicillin caused a concentration-dependent depression of heart rate and beat frequency [ 42 ].…”

Section: Discussionsupporting

confidence: 91%

Toxic Effects of Methylene Blue on the Growth, Reproduction and Physiology of Daphnia magna

Cui

Wen

et al. 2023

Toxics

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Methylene blue (MB) is a disinfectant used in aquaculture to prevent and treat fish diseases. However, the release of MB can pose a risk to the receiving water bodies. Zooplankton are the most sensitive organisms among aquatic life. Hence, this study examined the acute and chronic toxic effects of MB on zooplankton using Daphnia magna (D. magna) as a test organism to provide basic data for risk assessment. The results show that 48 h-EC50 and 24 h-LC50 were 61.5 ± 2.3 and 149.0 ± 2.2 μg/L, respectively. Chronic exposure to MB affected the heart rate, beat frequency of the thoracic limbs, and reproductive ability of D. magna at environmental concentrations higher than 4.7 μg/L. The cumulative molts, time to production of the first brood, and total number of living offspring were affected at different MB concentrations, while “abortions” were observed in high-exposure groups. The activity of superoxide dismutase was increased, while glutathione S-transferase activity was stimulated at low concentrations and inhibited at high concentrations. In addition, the malondialdehyde content increased with increasing concentrations of MB. Our findings demonstrate the impact of MB on the reproduction and growth of freshwater species, as well as their physiological responses. These results have implications for establishing guidelines on the use of MB in aquaculture and setting discharge standards.

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Section: Discussionsupporting

confidence: 91%

Toxic Effects of Methylene Blue on the Growth, Reproduction and Physiology of Daphnia magna

Cui

Wen

et al. 2023

Toxics

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“…Acrylamide, after being absorbed and distributed into several vital organs, causes serious harm. It has been reported that acrylamide is responsible for causing neurotoxicity, reproductive toxicity and cardiac developmental toxicity (Aldawood et al, 2020;Eghan et al, 2022). Moreover, in vivo studies have recently revealed that the intake of acrylamide induced splenic damages in adult zebrafish, and caused reduction of natural killer (NK) cells in female BALB/c mice (Fang et al, 2014;Komoike et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The effects of Yam polysaccharides on acrylamide-induced RAW264.7 cell polarization

Zhang,

Jin,

Han

et al. 2023

Journal of Food Bioactives

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We previously found that acrylamide (AA) damaged RAW264.7 cells (a kind of macrophages) by up-regulating P2X7 protein level, and Yam polysaccharides (YPS) could protect RAW264.7 cells against AA injury. Macrophages polarization may generate various subtypes which are closely related with cell function. However, how AA and YPS influence RAW264.7 polarization is unknown. In this study, we studied the effects of AA and YPS on the polarization of RAW264.7 cells. The killing effect of RAW264.7 cell on tumor cells has also been evaluated. The results showed that AA caused cell polarization towards M1-like macrophages by elevating CD86 and COX-2 protein expression and decreasing CD206 protein expression. Inhibiting the expression of P2X7 protein could effectively interfere with AA-induced M1 polarization. YPS could modulate AA-induced M1 polarization by reducing the ratio of CD86/CD206 but not COX-2 protein expression. RAW264.7 cell medium treated with AA had no effect on HepG2 cancer cell viability, but RAW264.7 cell medium treated with YPS significantly inhibited HepG2 cell viability. These findings suggested that YPS could regulate AA-induced RAW264.7 polarization and improve cell function. The results will provide reference for further explaining the mechanism of YPS intervening in toxic AA.

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Acute toxicity of tire wear particles and leachate to Daphnia magna

Liu

Qian

Yang

et al. 2023

Comparative Biochemistry and Physiology Part C: Toxicology &

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Cardiotoxicity and neurobehavioral effects induced by acrylamide in Daphnia magna

Cited by 11 publications

References 42 publications

Toxic Effects of Methylene Blue on the Growth, Reproduction and Physiology of Daphnia magna

Toxic Effects of Methylene Blue on the Growth, Reproduction and Physiology of Daphnia magna

The effects of Yam polysaccharides on acrylamide-induced RAW264.7 cell polarization

Acute toxicity of tire wear particles and leachate to Daphnia magna

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