Cardiovascular abnormalities associated with human and rodent obesity

Paulson, Dennis J.; Tahiliani, Arun G.

doi:10.1016/0024-3205(92)90618-y

Cited by 37 publications

(22 citation statements)

References 61 publications

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“…An increased cardiac lipid accumulation and cardiomyopathy was observed in mice with conditional cardiacspecific deletion of PPAR-␦ (Cheng et al, 2004). The present study was performed on relatively young Zucker fatty rats that were euglycemic and largely normotensive, with no impaired basal cardiac function (Paulson and Tahiliani 1992). However, the rats had already presented with enhanced circulating levels of FFA and TG and an elevated cardiac content of TG.…”

Section: Discussionmentioning

confidence: 94%

In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats

Yue

Nerurkar²,

Bao³

et al. 2008

J Pharmacol Exp Ther

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Section: Discussionmentioning

confidence: 94%

In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats

Yue

Nerurkar²,

Bao³

et al. 2008

J Pharmacol Exp Ther

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“…Single ventric-ular myocytes were isolated from adult male Sprague-Dawley rats (200 to 225 g) as described previously. 18 Briefly, the animals were euthanized, and their hearts were rapidly removed and perfused (at 37°C) with oxygenated (5%CO 2 25, HEPES 10, and glucose 11.1, pH 7.4). Hearts were subsequently perfused with a nominally Ca 2ϩ -free KHB buffer for 2 to 3 minutes until spontaneous contractions ceased, followed by a 20-minute perfusion with Ca 2ϩ -free KHB containing 223 U/mL collagenase (Worthington Biochemical Corp) and 0.1 mg/mL hyaluronidase (Sigma Chemical Co).…”

Section: Isolation Of Ventricular Myocytesmentioning

confidence: 99%

Leptin Attenuates Cardiac Contraction in Rat Ventricular Myocytes

et al. 2000

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Abstract-Obesity is commonly associated with impaired myocardial contractile function. However, a direct link between these 2 states has not yet been established. There has been an indication that leptin, the product of the human obesity gene, may play a role in obesity-related metabolic and cardiovascular dysfunctions. The purpose of this study was to determine whether leptin exerts any direct cardiac contractile action that may contribute to altered myocardial function. Ventricular myocytes were isolated from adult male Sprague-Dawley rats. Contractile responses were evaluated by use of video-based edge detection. Contractile properties analyzed in cells electrically stimulated at 0.5 Hz included peak shortening, time to 90% peak shortening, time to 90% relengthening, and fluorescence intensity change. Leptin exhibited a dose-dependent inhibition in myocyte shortening and intracellular Ca 2ϩ change, with maximal inhibitions of 22.4% and 26.2%, respectively. Pretreatment with the NO synthase inhibitor N -nitro-L-arginine methyl ester (L-NAME, 100 mol/L) blocked leptin-induced inhibition of both peak shortening and fluorescence intensity change. Leptin also stimulated NO synthase activity in a time-and concentration-dependent manner, as reflected in the dose-related increase in NO accumulation in these cells. Addition of an NO donor (S-nitroso-N-acetyl-penicillamine [SNAP]) to the medium mimicked the effects of leptin administration. In summary, this study demonstrated a direct action of leptin on cardiomyocyte contraction, possibly through an increased NO production. These data suggest that leptin may play a role in obesity-related cardiac contractile dysfunction. (Hypertension. 2000;36:501-505.)

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“…Obesity is an independent risk factor for cardiac disease 7) which has been associated conditions such as hypertension and diabetes. For example, as with other heart failure risk factors, obesity frequently leads to left ventricular hypertrophy, [8][9][10][11] and because of its epidemic nature in developed societies, obesity is a very important public health problem. 12,13) Keeping the body weight level within the normal range is important for the prevention of variety diseases such as arteriosclerosis, cerebral apoplexy and myocardial infarction etc.…”

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confidence: 99%

Structure of New Monoterpene Glycoside from Sibiraea angustata RCHD. and Its Anti-obestic Effect

Ito

Kamo

Sadhu

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Sibiraea angustata RCHD. (Rosaceae) is a shrub found at high-elevation dryland around 3000 to 4000 m height in the areas of Xizang (Tibet), Sichuan, Qinghai, Gansu and Yunnan in China. The Tibetans believe that a long-term consumption of the aerial part of S. angustata as tea has some benefit of health in humans. And they avoid mixing this plant into sheep feed, since it has been practically known to cause weight-loss during ingestion. It was no more than one of folklores before our study. These traditions were not recorded on any literature, but directly collected by our hearing from Tibetans. This folklore leads to the hypothesis that the aerial part of S. angustata might have preventive effects on obesity. Then, we had interest and study about the properties of S. angustata.In the previous studies, 43 essential oils 1) and glucityl ferulate (sibirate)2) were identified from the aerial part of S. angustata. The extract of S. angustata improved immune system 3) and prevented CCl 4 -induced liver diseases. 4) However, the active ingredients for these pharmacological effects have not yet been identified.In this study, we present the isolation and structure determination of a new compound (1), together with two known compounds, isoferulic acid and quercetin 3-O-a-L-arabinopyranosyl(1-6)-b-D-galactopyranoside 5) from the aerial part of S. angustata, and the anti-obestic effect of 1 is also discussed. Results and DiscussionsThe aerial part of S. angustata was boiled in water and the decoction was spray dried. C-NMR and DEPT spectra suggested the presence of two tertiary methyl groups, three methylenes, seven methines, three quaternary carbons including a carbonyl group. In addition, heteronuclear single quantum correlation (HSQC) analysis suggested the presence of a methine (d C 124.1) overlapped with a signal due to the solvent (pyridine) ( Table 1).The chemical structure of the compound 1 was elucidated by 1 H-1 H correlation spectroscoopy (COSY), nuclear overhauser effect spectroscopy (NOESY), HSQC and heteronuclear multiple bond correlation (HMBC) analyses (Fig. 1). The connectives of these partial structures and the functional groups were determined by analysis of HMBC. As shown in Fig. 1, key long range correlations were observed between the following proton and carbon signals: H-1 and C-2, C-3; H-2 and C-4, C-10; H-4 (a and b) and C-3, C-6; H-6 and C-7, C-8, C-9; H-8 and C-6, C-7, C-9; H-9 and C-6, C-7, C-8; H-1Ј and C-1. Furthermore, NOESY spectrum exhibited Iskra Industry Co., Ltd.; Japan: b Graduate School of Pharmaceutical Sciences, Chiba University; Japan: and c Institute of Natural Medicine, University of Toyama; 2630 Sugitani, Toyama 930-0194, Japan. Received October 8, 2008 accepted December 19, 2008; published online January 8, 2009 A new monoterpene glycoside (1) isolated from the aerial part of Sibirae angustata RCHD. (Rosaceae) was found to be 1-O-b b-D-glucopyranosyl-geraniol-5,10-olide and named as sibiskoside. Acute toxicity study revealed that oral administration of 1 (2.5 g/kg body w...

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Cardiovascular abnormalities associated with human and rodent obesity

Cited by 37 publications

References 61 publications

In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats

In Vivo Activation of Peroxisome Proliferator-Activated Receptor-δ Protects the Heart from Ischemia/Reperfusion Injury in Zucker Fatty Rats

Leptin Attenuates Cardiac Contraction in Rat Ventricular Myocytes

Structure of New Monoterpene Glycoside from Sibiraea angustata RCHD. and Its Anti-obestic Effect

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