1997
DOI: 10.1111/j.1600-0773.1997.tb00023.x
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Cardiovascular Actions of Chronic Intracerebroventricular Administration of Metformin in Normotensive Rats

Abstract: Abstrucr; Acute intracerebroventricular administration of the antihyperglycaemic agent metformin (0.25-1 mg) elicits sympathoinhibitory responses in spontaneously hypertensive rats. However, cardiovascular actions of chronic intracerebroventricular metformin administration are unknown. To define the dose-response relationship during chronic intracerebroventricular metformin administration, mean arterial pressure, heart rate, and locomotor activity were measured continuously by radiotelemetry in 40 normotensive… Show more

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Cited by 3 publications
(1 citation statement)
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“…Although we cannot rule out this possibility, recent studies have failed to demonstrate metformin-induced reductions in locomotor activity in Wistar rats. 27 The nighttime attenuation in blood pressure may also be related to the feeding patterns of rats. Because rats feed and drink at night, the acute hypotensive actions of metformin, administered in the drinking water, would be expected to be most pronounced during that period.…”
Section: Discussionmentioning
confidence: 99%
“…Although we cannot rule out this possibility, recent studies have failed to demonstrate metformin-induced reductions in locomotor activity in Wistar rats. 27 The nighttime attenuation in blood pressure may also be related to the feeding patterns of rats. Because rats feed and drink at night, the acute hypotensive actions of metformin, administered in the drinking water, would be expected to be most pronounced during that period.…”
Section: Discussionmentioning
confidence: 99%